XY-ZH compounds as potential 1,3-dipoles. Part 65: Atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines

Tetrahedron

Volumn 67, Issue 31, 2011, Pages 5700-5710

  Elboray, Elghareeb E ^a,b   Grigg, Ronald ^a   Fishwick, Colin W G ^a   Kilner, Colin ^a   Sarker, Mohammed A B ^a   Aly, Moustafa F ^b   Abbas Temirek, Hussien H ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b SOUTH VALLEY UNIVERSITY   (Egypt)

Author keywords

Azomethine ylides; Cascade reactions; Cycloaddition; Iminium ion; Pyrimidinylpyrrolidines

Indexed keywords

1,3 DIPOLE DERIVATIVE; 3' (4,6 DIMETHYLPYRIMIDIN 2 YL) 5' METHYLDIHYDRO 2H,2'H SPIRO[AZEPANE 3,1' PYRROLO[3,4 C]PYRROLE] 2,4',6'(3'H,5'H) TRIONE; 3' (4,6 DIMETHYLPYRIMIDIN 2 YL) 5' METHYLTETRAHYDRO 2'H SPIRO[FURAN 3,1' PYRROLO[3,4 C]PYRROLE] 2,4',6' (3'H,5'H) -TRIONE; 4 (1H BENZIMIDAZOL 2 YL) 6 (4,6 DIMETHYLPYRIMIDIN 2 YL)TETRAHYDROPYRROLO[3,4 C]PYRROLE 1,3(2H,3AH) DIONE; 4 (4,6 DIMETHYLPYRIMIDIN 2 YL) 1,3 DIOXO 2 PHENYLOCTAHYDROPYRROLO[3,4 A]PYRROLIZINE 8A(6H) CARBOXAMIDE; 4 (4,6 DIMETHYLPYRIMIDIN 2 YL) 6 (PYRIDIN 2 YL)TETRAHYDROPYRROLO[3,4 C]PYRROLE 1,3(2H,3AH) DIONE; 4 [3 CHLORO 5 (TRIFLUOROMETHYL)PYRIDIN 2 YL] 6 (4,6 DIMETHYLPYRIMIDIN 2 YL)TETRAHYDROPYRROLO[3,4 C]PYRROLE 1,3(2H,3AH) DIONE; 4,6 DIMETHYL 2 [4 (PHENYLSULFONYL) 5 (PYRIDIN 2 YL)PYRROLIDIN 2 YL]PYRIMIDINE; 4,6 DIMETHYL 2 FORMYLPYRIMIDINE; ALDEHYDE DERIVATIVE; ALIPHATIC COMPOUND; AMINE; AMINO ESTER; BRONSTED ACID; ESTER DERIVATIVE; HETEROCYCLIC AMINE; IMIDE; LEWIS ACID; MALEIMIDE DERIVATIVE; METHYL 1 BENZYL 3 (4,6 DIMETHYLPYRIMIDIN 2 YL) 4,6 DIOXOOCTAHYDROPYRROLO[3,4 C]PYRROLE 1 CARBOXYLATE; METHYL 3 (4,6 DIMETHYLPYRIMIDIN 2 YL) 1 (1H INDOL 3 YLMETHYL) 4,6 DIOXOOCTAHYDROPYRROLO[3,4 C]PYRROLE 1 CARBOXYLATE; METHYL 3 (4,6 DIMETHYLPYRIMIDIN 2 YL) 1 [2 (METHYLTHIO) 4,6 DIOXOOCTAHYDROPYRROLO[3,4 C]PYRROLE 1 CARBOXYLATE; METHYL 3 (4,6 DIMETHYLPYRIMIDIN 2 YL) 1 METHYL 4,6 DIOXOOCTAHYDROPYRROLO[3,4 C]PYRROLE 1 CARBOXYLATE; METHYL 5 (4,6 DIMETHYLPYRIMIDIN 2 YL) 2 METHYL 3 (PHENYLSULFONYL)PYRROLIDINE 2 CARBOXYLATE; METHYL 5 (4,6 DIMETHYLPYRIMIDIN 2 YL) 2 METHYL 4 (PHENYLSULFONYL)PYRROLIDINE 2 CARBOXYLATE; N METHYLMALEIMIDE; ORGANIC COMPOUND; PYRIMIDINE DERIVATIVE; PYRIMIDINYLPYRROLIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CYCLOADDITION; DIASTEREOISOMER; DIPOLE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 79959725456     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.05.074     Document Type: Article

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