Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer

Breast Cancer Research and Treatment

Volumn 128, Issue 2, 2011, Pages 391-400

  Wu, Xinyu ^a   Chen, Fei ^a   Sahin, Aysegul ^b   Albarracin, Constance ^b   Pei, Zhiheng ^a   Zou, Xuanyi ^a   Singh, Baljit ^a   Xu, Ruliang ^a   Daniels, Garrett ^a   Li, Yirong ^a   Wei, Jianjun ^a   Blake, Marvin ^c   Schneider, Robert J ^a   Cowin, Pamela ^a   Lee, Peng ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

AR coactivator; ARA70; Breast cancer; Mammary gland development

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ESTROGEN; ESTROGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARA70ALPHA GENE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST DEVELOPMENT; BREAST HYPOPLASIA; CANCER CELL; CANCER GROWTH; CANCER INVASION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; METASTASIS; NONHUMAN; ONCOGENE; ONCOGENE ARA70BETA; PREGNANCY; PRIORITY JOURNAL; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; HUMANS; LUCIFERASES; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; NUCLEAR RECEPTOR COACTIVATORS; PROMOTER REGIONS, GENETIC; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 79959694638     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1131-5     Document Type: Article

References (34)

1. A Romano, et al. 2009 Identification of novel ER-alpha target genes in breast cancer cells: gene- and cell-selective co-regulator recruitment at target promoters determines the response to 17beta-estradiol and tamoxifen Mol Cell Endocrinol 314 90 100 19698761 10.1016/j.mce.2009.08.008
2. AO Brinkmann, et al. 1999 Mechanisms of androgen receptor activation and function J Steroid Biochem Mol Biol 69 1-6 307 313 10419007 10.1016/S0960- 0760(99)00049-7 1:CAS:528:DyaK1MXktlOmur8%3D (Pubitemid 29305551)
3. SN Agoff, et al. 2003 Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations Am J Clin Pathol 120 5 725 731 14608899 10.1309/42F00D0DJD0J5EDT 1:CAS:528:DC%2BD3sXpsVOnsL8%3D (Pubitemid 37339680)
4. S Ando, et al. 2002 Breast cancer: from estrogen to androgen receptor Mol Cell Endocrinol 193 1-2 121 128 12161011 10.1016/S0303-7207(02)00105-3 1:CAS:528:DC%2BD38XlvVert78%3D (Pubitemid 34823616)
5. SN Birrell, et al. 1995 Androgens induce divergent proliferative responses in human breast cancer cell lines J Steroid Biochem Mol Biol 52 5 459 467 7748811 10.1016/0960-0760(95)00005-K 1:CAS:528:DyaK2MXlvVGkt7k%3D
6. M Santoro, et al. 1994 Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma Oncogene 9 2 509 516 8290261 1:CAS:528:DyaK2cXitlOnt7Y%3D (Pubitemid 24041530)
7. I Bongarzone, et al. 1994 Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas Cancer Res 54 11 2979 2985 8187085 1:CAS:528:DyaK2cXktlahsrw%3D (Pubitemid 24187783)
8. F Minoletti, et al. 1994 The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2 Genes Chromosomes Cancer 11 1 51 57 7529046 10.1002/gcc.2870110108 1:CAS:528:DyaK2MXhtVWhtrc%3D (Pubitemid 24273973)
9. SY Yeh CS Chang 1996 Cloning and characterization of a specific coactivator, ARA(70), for the androgen receptor in human prostate cells Proc Natl Acad Sci USA 93 11 5517 5521 8643607 10.1073/pnas.93.11.5517 1:CAS:528:DyaK28Xjt1Ojsbw%3D (Pubitemid 26159482)
10. TH Thin, et al. 2002 Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17 beta-estradiol-induced androgen receptor transactivation J Biol Chem 277 39 36499 36508 12068007 10.1074/jbc.M202824200 1:CAS:528:DC%2BD38XnsVCjtbc%3D
11. MM Rahman, et al. 2003 Reducing the agonist activity of antiandrogens by a dominant-negative androgen receptor coregulator ARA70 in prostate cancer cells J Biol Chem 278 22 19619 19626 12649293 10.1074/jbc.M210941200 1:CAS:528:DC%2BD3sXktVaqsb4%3D (Pubitemid 36799145)
12. YC Hu, et al. 2004 Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer J Biol Chem 279 32 33438 33446 15166229 10.1074/jbc.M401781200 1:CAS:528:DC%2BD2cXmtFOitL4%3D (Pubitemid 39062993)
13. P Alen, et al. 1999 Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform Mol Endocrinol 13 1 117 128 9892017 10.1210/me.13.1.117 1:CAS:528:DyaK1MXisVynuw%3D%3D (Pubitemid 29022284)
14. M Lanzino, et al. 2005 Endogenous coactivator ARA70 interacts with ERa and modulates the functional ERalpha/AR interplay in MCF-7 cells J Biol Chem 280 21 20421 20430 15772083 10.1074/jbc.M413576200 1:CAS:528:DC%2BD2MXktlCmu7g%3D (Pubitemid 40776741)
15. I Bieche, et al. 2001 Quantitation of androgen receptor gene expression in sporadic breast tumors by real-time RT-PCR: evidence that MYC is an AR-regulated gene Carcinogenesis 22 9 1521 1526 11532875 10.1093/carcin/22.9. 1521 1:CAS:528:DC%2BD3MXmvVymurc%3D (Pubitemid 32898710)
16. A Magklara TJ Brown EP Diamandis 2002 Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3 Int J Cancer 100 5 507 514 12124798 10.1002/ijc.10520 1:CAS:528:DC%2BD38Xlslyjsb4%3D (Pubitemid 34816149)
17. A Kollara, et al. 2001 Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers Breast Cancer Res Treat 67 3 245 253 11561770 10.1023/A:1017938608460 1:CAS:528: DC%2BD3MXntFGlt7g%3D (Pubitemid 32803530)
18. M Lanzino, et al. 2005 Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells J Biol Chem 280 21 20421 20430 15772083 10.1074/jbc.M413576200 1:CAS:528:DC%2BD2MXktlCmu7g%3D (Pubitemid 40776741)
19. P Li, et al. 2002 Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer Am J Pathol 161 4 1467 1474 12368219 10.1016/S0002-9440(10)64422-7 1:CAS:528:DC%2BD38Xotl2jtrk%3D
20. Y Peng, et al. 2008 Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70 Am J Pathol 172 1 225 235 18156210 10.2353/ajpath.2008.070065 1:CAS:528:DC%2BD1cXhslOmu7k%3D (Pubitemid 351186383)
21. Ligr M and Lee P (2009) Tumor suppressor function of androgen receptor coactivator ARA70α in prostate cancer. Am J Pathol (in press)
22. L Wang, et al. 2009 Increased expression of histone deacetylaces (HDACs) and inhibition of prostate cancer growth and invasion by HDAC inhibitor SAHA Am J Transl Res 1 1 62 71 19966939 1:CAS:528:DC%2BD1MXhtFejs7jI
23. Y Peng, et al. 2008 Androgen receptor coactivator ARA70alpha and ARA70beta isoform-specific antibodies: new tools for studies of expression and immunohistochemical localization Appl Immunohistochem Mol Morphol 16 1 7 12 18091327 1:CAS:528:DC%2BD1cXhsVSlsLg%3D
24. A Imbert, et al. 2001 Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland J Cell Biol 153 3 555 568 11331306 10.1083/jcb.153.3.555 1:CAS:528:DC%2BD3MXjt1alsL8%3D (Pubitemid 34280142)
25. EP Witty JH Wright LM Matrisian 1995 Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development Mol Biol Cell 6 10 1287 1303 8573787 1:CAS:528:DyaK2MXoslWrtL4%3D
26. LM Arendt, et al. 2006 Prolactin potentiates transforming growth factor alpha induction of mammary neoplasia in transgenic mice Am J Pathol 168 4 1365 1374 16565509 10.2353/ajpath.2006.050861 1:CAS:528:DC%2BD28XjslOhu7s%3D
27. K Hosohata, et al. 2003 Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription Mol Cell Biol 23 19 7019 7029 12972618 10.1128/MCB.23.19.7019-7029.2003 1:CAS:528:DC%2BD3sXnvVyisLs%3D (Pubitemid 37214668)
28. Peng Y et al. (2009) Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion. J cell mol med (in press)
29. M Ligr, et al. 2010 Tumor suppressor function of androgen receptor coactivator ARA70{alpha} in prostate cancer Am J Pathol 176 1891 1900 20167864 10.2353/ajpath.2010.090293 1:CAS:528:DC%2BC3cXltlels74%3D
30. H Rochefort, et al. 1998 Estrogen receptor mediated inhibition of cancer cell invasion and motility: an overview J Steroid Biochem Mol Biol 65 1-6 163 168 9699869 10.1016/S0960-0760(98)00010-7 1:CAS:528:DyaK1cXkvVKru7k%3D (Pubitemid 28335602)
31. HA Molenda, et al. 2003 Nuclear receptor coactivator function in reproductive physiology and behavior Biol Reprod 69 5 1449 1457 12855594 10.1095/biolreprod.103.019364 1:CAS:528:DC%2BD3sXosV2kur4%3D (Pubitemid 37362825)
32. A Mukherjee, et al. 2007 Steroid receptor coactivator 2: an essential coregulator of progestin-induced uterine and mammary morphogenesis Ernst Schering Found Symp Proc 1 55 76 18540568 10.1007/2789-2007-057
33. J Xu, et al. 2000 The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development Proc Natl Acad Sci USA 97 12 6379 6384 10823921 10.1073/pnas.120166297 1:CAS:528:DC%2BD3cXktFajs7s%3D (Pubitemid 30412722)
34. MI Torres-Arzayus, et al. 2004 High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene Cancer Cell 6 3 263 274 15380517 10.1016/j.ccr.2004.06.027 1:CAS:528:DC%2BD2cXot1Kis7Y%3D (Pubitemid 39222039)