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Volumn 31, Issue 2, 2011, Pages 195-204

Hepatitis B e-antigen persistency is associated with the properties of HBV-specific CD8 T cells in CHB patients

Author keywords

HBV specific T cellular response; Hepatitis B e antigen; histological grades; PD 1; viral load

Indexed keywords

ALANINE AMINOTRANSFERASE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HEPATITIS B(E) ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; VIRUS DNA;

EID: 79959692373     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9483-5     Document Type: Article
Times cited : (29)

References (36)
  • 1
    • 0036614299 scopus 로고    scopus 로고
    • Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    • Hsu YS, Chien RN, Yeh CT, Sheen IS, Chiou HY, Chu CM, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology. 2002;35:1522-7.
    • (2002) Hepatology , vol.35 , pp. 1522-1527
    • Hsu, Y.S.1    Chien, R.N.2    Yeh, C.T.3    Sheen, I.S.4    Chiou, H.Y.5    Chu, C.M.6
  • 2
    • 0035123958 scopus 로고    scopus 로고
    • Acute flares in chronic hepatitis B: The natural and unnatural history of an immunologically mediated liver disease
    • Perrillo RP. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology. 2001;120:1009-22. (Pubitemid 32193199)
    • (2001) Gastroenterology , vol.120 , Issue.4 , pp. 1009-1022
    • Perrillo, R.P.1
  • 3
    • 0035189597 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • DOI 10.1053/jhep.2001.29401
    • Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2001;34:1225-41. (Pubitemid 33096596)
    • (2001) Hepatology , vol.34 , Issue.6 , pp. 1225-1241
    • Lok, A.S.F.1    McMahon, B.J.2
  • 4
    • 0030071827 scopus 로고    scopus 로고
    • Precore mutants revisited
    • DOI 10.1053/jhep.1996.v23.ajhep0230184
    • Baumert TF, Liang TJ. Precore mutants revisited. Hepatology. 1996;23:184-6. (Pubitemid 26012108)
    • (1996) Hepatology , vol.23 , Issue.1 , pp. 184-186
    • Baumert, T.F.1    Liang, T.J.2
  • 5
    • 0032519919 scopus 로고    scopus 로고
    • The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: A mechanism for persistence
    • Milich DR, Chen MK, Hughes JL, Jones JE. The secreted hepatitis B precore antigen can modulate the immune response to the nucleocapsid: a mechanism for persistence. J Immunol. 1998;160:2013-21. (Pubitemid 28106492)
    • (1998) Journal of Immunology , vol.160 , Issue.4 , pp. 2013-2021
    • Milich, D.R.1    Chen, M.K.2    Hughes, J.L.3    Jones, J.E.4
  • 6
    • 0142151773 scopus 로고    scopus 로고
    • Exploring the Biological Basis of Hepatitis B e Antigen in Hepatitis B Virus Infection
    • DOI 10.1053/jhep.2003.50453
    • Milich DR, Liang TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology. 2003;38:1075-86. (Pubitemid 37314815)
    • (2003) Hepatology , vol.38 , Issue.5 , pp. 1075-1086
    • Milich, D.1    Liang, T.J.2
  • 7
    • 0035893038 scopus 로고    scopus 로고
    • The Src-protein tyrosine kinase Lck is required for IL-1-mediated costimulatory signaling in Th2 cells
    • al-Ramadi BK, Welte T, Fernandez-Cabezudo MJ, Galadari S, Dittel B, Fu XY, et al. The Src-protein tyrosine kinase Lck is required for IL-1-mediated costimulatory signaling in Th2 cells. J Immunol. 2001;167:6827-33.
    • (2001) J Immunol , vol.167 , pp. 6827-6833
    • Al-Ramadi, B.K.1    Welte, T.2    Fernandez-Cabezudo, M.J.3    Galadari, S.4    Dittel, B.5    Fu, X.Y.6
  • 9
    • 34247571427 scopus 로고    scopus 로고
    • Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection
    • DOI 10.1111/j.1478-3231.2006.01400.x
    • Du H, Li T, Zhang HY, He ZP, Qong QM, Duan XZ, et al. Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection. Liver Int. 2007;27:240-6. (Pubitemid 46680729)
    • (2007) Liver International , vol.27 , Issue.2 , pp. 240-246
    • Du, H.1    Li, T.2    Zhang, H.-Y.3    He, Z.-P.4    Dong, Q.-M.5    Duan, X.-Z.6    Zhuang, H.7
  • 11
    • 34848870566 scopus 로고    scopus 로고
    • Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma
    • DOI 10.1016/j.jhep.2007.06.019, PII S0168827807004266
    • Sun HC, Zhang W, Qin LX, Zhang BH, Ye QH, Wang L, et al. Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma. J Hepatol. 2007;47:684-90. (Pubitemid 47503431)
    • (2007) Journal of Hepatology , vol.47 , Issue.5 , pp. 684-690
    • Sun, H.-C.1    Zhang, W.2    Qin, L.-X.3    Zhang, B.-H.4    Ye, Q.-H.5    Wang, L.6    Ren, N.7    Zhuang, P.-Y.8    Zhu, X.-D.9    Fan, J.10    Tang, Z.-Y.11
  • 13
    • 0030990610 scopus 로고    scopus 로고
    • Are alanine aminotransferase, hepatitis B virus DNA or IgM antibody to hepatitis B core antigen serum levels predictors of histological grading in chronic hepatitis B?
    • Zavaglia C, Mondazzi L, Maggi G, Iamoni G, Gelosa F, Bellati G, et al. Are alanine aminotransferase, hepatitis B virus DNA or IgM antibody to hepatitis B core antigen serum levels predictors of histological grading in chronic hepatitis B. Liver. 1997;17:83-7. (Pubitemid 27179981)
    • (1997) Liver , vol.17 , Issue.2 , pp. 83-87
    • Zavaglia, C.1    Mondazzi, L.2    Maggi, G.3    Iamoni, G.4    Gelosa, F.5    Bellati, G.6    Colloredo, G.7    Bottelli, R.8    Ideo, G.9
  • 14
    • 34548475512 scopus 로고    scopus 로고
    • Impaired Intrahepatic Hepatitis B Virus Productivity Contributes to Low Viremia in Most HBeAg-Negative Patients
    • DOI 10.1053/j.gastro.2007.06.057, PII S0016508507012899
    • Volz T, Lutgehetmann M, Wachtler P, Jacob A, Quaas A, Murray JM, et al. Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients. Gastroenterology. 2007;133:843-52. (Pubitemid 47374140)
    • (2007) Gastroenterology , vol.133 , Issue.3 , pp. 843-852
    • Volz, T.1    Lutgehetmann, M.2    Wachtler, P.3    Jacob, A.4    Quaas, A.5    Murray, J.M.6    Dandri, M.7    Petersen, J.8
  • 15
    • 0033911223 scopus 로고    scopus 로고
    • Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B
    • Lindh M, Horal P, Dhillon AP, Norkrans G. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B. J Viral Hepat. 2000;7:258-67.
    • (2000) J Viral Hepat , vol.7 , pp. 258-267
    • Lindh, M.1    Horal, P.2    Dhillon, A.P.3    Norkrans, G.4
  • 16
    • 36349010112 scopus 로고    scopus 로고
    • Hepatitis B virus DNA prediction rules for hepatitis B e antigen-negative chronic hepatitis B
    • DOI 10.1002/hep.21811
    • Feld JJ, Ayers M, El-Ashry D, Mazzulli T, Tellier R, Heathcote EJ. Hepatitis B virus DNA prediction rules for hepatitis B e antigen-negative chronic hepatitis B. Hepatology. 2007;46:1057-70. (Pubitemid 350147802)
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1057-1070
    • Feld, J.J.1    Ayers, M.2    El-Ashry, D.3    Mazzulli, T.4    Tellier, R.5    Heathcote, E.J.6
  • 17
    • 7044247947 scopus 로고    scopus 로고
    • + regulatory T lymphocytes in hepatitis C virus infection
    • DOI 10.1002/hep.20454
    • Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, et al. An immunomodulatory role for CD4+ CD25+ regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004;40:1062-71. (Pubitemid 39425561)
    • (2004) Hepatology , vol.40 , Issue.5 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6    Nelson, D.R.7
  • 18
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • DOI 10.1002/hep.20649
    • Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology. 2005;41:771-8. (Pubitemid 40462939)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 771-778
    • Stoop, J.N.1    Van Der, M.R.G.2    Baan, C.C.3    Van Der, L.L.J.W.4    Kuipers, E.J.5    Kusters, J.G.6    Janssen, H.L.A.7
  • 19
    • 37149016672 scopus 로고    scopus 로고
    • + regulatory T cells correlate with chronic hepatitis B infection
    • DOI 10.1111/j.1365-2567.2007.02691.x
    • Peng G, Li S, Wu W, Sun Z, Chen Y, Chen Z. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology. 2008;123:57-65. (Pubitemid 350255997)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 57-65
    • Peng, G.1    Li, S.2    Wu, W.3    Sun, Z.4    Chen, Y.5    Chen, Z.6
  • 20
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1:4331-5.
    • (1981) Hepatology , vol.1 , pp. 4331-4335
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3    Chen, T.S.4    Craig, R.5    Kaplowitz, N.6
  • 21
    • 33845605881 scopus 로고    scopus 로고
    • Analysis of differential gene expression between chronic hepatitis B patients and asymptomatic hepatitis B carriers
    • Tang CL, Chen Z, Peng GP, Yang ZG, Zhou LF. Analysis of differential gene expression between chronic hepatitis B patients and asymptomatic hepatitis B carriers. J Gastroenterol Hepatol. 2006;22:74-9.
    • (2006) J Gastroenterol Hepatol , vol.22 , pp. 74-79
    • Tang, C.L.1    Chen, Z.2    Peng, G.P.3    Yang, Z.G.4    Zhou, L.F.5
  • 22
    • 0033636568 scopus 로고    scopus 로고
    • Risk factors for active liver disease in HbeAg-negative chronic hepatitis B virus-infected patients
    • Chan HL, Hui Y, Leung NW, Ching JY, Chan FK, Sung JJ. Risk factors for active liver disease in HbeAg-negative chronic hepatitis B virus-infected patients. Am J Gastroenterol. 2000;95:3547-51.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3547-3551
    • Chan, H.L.1    Hui, Y.2    Leung, N.W.3    Ching, J.Y.4    Chan, F.K.5    Sung, J.J.6
  • 24
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • DOI 10.1053/j.gastro.2005.11.016, PII S0016508505022766
    • Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology. 2006;130:678-86. (Pubitemid 43374518)
    • (2006) Gastroenterology , vol.130 , Issue.3 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.-I.2    Su, J.3    Jen, C.-L.4    You, S.-L.5    Chen, C.-J.6
  • 25
    • 0030021968 scopus 로고    scopus 로고
    • Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
    • DOI 10.1016/S1074-7613(00)80295-2
    • Guidotti LG, Ishikawa T, Hobbs MV, Matzeke B, Schreiber R, Chisari FV. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity. 1996;4:25-36. (Pubitemid 26054933)
    • (1996) Immunity , vol.4 , Issue.1 , pp. 25-36
    • Guidotti, L.G.1    Ishikawa, T.2    Hobbs, M.V.3    Matzke, B.4    Schreiber, R.5    Chisari, F.V.6
  • 26
    • 0033754709 scopus 로고    scopus 로고
    • No Significant correlation exists between core promoter mutations, viral replication, and liver damage in chronic hepatitis B infection
    • Chun Y, Kim JY, Woo H, Oh SM, Kang I, Ha J, et al. No Significant correlation exists between core promoter mutations, viral replication, and liver damage in chronic hepatitis B infection. Hepatology. 2000;32:1154-62.
    • (2000) Hepatology , vol.32 , pp. 1154-1162
    • Chun, Y.1    Kim, J.Y.2    Woo, H.3    Oh, S.M.4    Kang, I.5    Ha, J.6
  • 27
    • 0032754504 scopus 로고    scopus 로고
    • Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection
    • Maini MK, Boni C, Ogg GS, King AS, Reignat S, Lee CK, et al. Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection. Gastroenterology. 1999;117:1386-96.
    • (1999) Gastroenterology , vol.117 , pp. 1386-1396
    • Maini, M.K.1    Boni, C.2    Ogg, G.S.3    King, A.S.4    Reignat, S.5    Lee, C.K.6
  • 29
    • 75149117314 scopus 로고    scopus 로고
    • Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B
    • Fisicaro P, Valdatta C, Massari M, Loggi E, Biasini E, Sacchelli L, et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology. 2010;138:682-93.
    • (2010) Gastroenterology , vol.138 , pp. 682-693
    • Fisicaro, P.1    Valdatta, C.2    Massari, M.3    Loggi, E.4    Biasini, E.5    Sacchelli, L.6
  • 30
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25+ CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, et al. Immunologic self-tolerance maintained by CD25+ CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-10.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6
  • 32
    • 68549127012 scopus 로고    scopus 로고
    • CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients
    • Yu Y, Wu H, Tang Z, Zang G. CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients. Cell Mol Immunol. 2009;6:123-7.
    • (2009) Cell Mol Immunol , vol.6 , pp. 123-127
    • Yu, Y.1    Wu, H.2    Tang, Z.3    Zang, G.4
  • 33
    • 0036301503 scopus 로고    scopus 로고
    • CTLA-4: New insights into its biological function and use in tumor immunotherapy
    • DOI 10.1038/ni0702-611
    • Egen JG, Kuhns MS, Allison JP. CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol. 2002;3:611-8. (Pubitemid 34752469)
    • (2002) Nature Immunology , vol.3 , Issue.7 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 34
    • 35648968689 scopus 로고    scopus 로고
    • PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
    • DOI 10.1016/j.molimm.2007.07.038, PII S0161589007006736
    • Peng G, Li S, Wu W, Tan X, Chen Y, Chen Z. PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Mol Immunol. 2008;45:963-70. (Pubitemid 350019503)
    • (2008) Molecular Immunology , vol.45 , Issue.4 , pp. 963-970
    • Peng, G.1    Li, S.2    Wu, W.3    Tan, X.4    Chen, Y.5    Chen, Z.6
  • 35
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Currana MA, Montalvoa W, Yagitab H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci USA. 2010;107:4275-80.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4275-4280
    • Currana, M.A.1    Montalvoa, W.2    Yagitab, H.3    Allison, J.P.4
  • 36
    • 61449181280 scopus 로고    scopus 로고
    • Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
    • Nakamoto N, Cho H, Shaked A, Olthoff K, Valiga ME, Kaminski M, et al. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog. 2009;5:1-13.
    • (2009) PLoS Pathog , vol.5 , pp. 1-13
    • Nakamoto, N.1    Cho, H.2    Shaked, A.3    Olthoff, K.4    Valiga, M.E.5    Kaminski, M.6


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