Incorporating gender and sex dimensions in medical research

Interdisciplinary Science Reviews

Volumn 36, Issue 2, 2011, Pages 180-192

  Holdcroft, Anita ^a   Snidvongs, Saowarat ^b   Berkley, Karen J ^c  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

^c FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Clinical outcomes; Clinical research; Life span factors; Personalized therapies; Sex differences; Sociocultural determinants

Indexed keywords

EID: 79959672479     PISSN: 03080188     EISSN: 17432790     Source Type: Journal    
DOI: 10.1179/030801811X13013181961590     Document Type: Article

References (42)

1. Abbasi, Kamran. 2011. The dawn of revolutionary medicine. Journal of the Royal Society of Medicine 104: 1, doi 10.1258/jrsm.2010.10k075.
2. Association of the British Pharmaceutical Industry. 2007. Guidelines for Phase 1 clinical trials. ABPI. http:// www.abpi.org.uk/%2Fpublications%2Fpdfs%2Fphase1_guidelines.pdf. (13/02/2011)
3. Baker, Peter. 2001. The international men's health movement has grown to the stage that it can start to inß uence international bodies. British Medical Journal 323: 1014-5.
4. Becker, Jill B., Arthur P. Arnold, Karen J. Berkley, Jeffrey D. Blaustein, Lisa A. Eckel, Elizabeth Hampson, James P. Herman, Sherry Marts, Wolfgang Sadee, Meir Steiner, Jane Taylor, and Elizabeth Young. 2005. Strategies and methods for research on sex differences in brain and behavior. Endocrinology 146(4): 1650-73.
5. Downing, Amy, Gavin Rudge, Yaping Cheng, Yu-Kang Tu, Justin Keen, and Mark S. Gilthorpe. 2007. Do the UK government's new Quality and Outcomes Framework (QOF) scores adequately measure primary care performance? A cross-sectional survey of routine health care data. BMC Health Services Research 7: 166.
6. Du, Lina, Hülya Bayir, Yichen Lai, Xiaopeng Zhang, Patrick M. Kochanek, Simon C. Watkins, Steven H. Graham, and Robert S. Clark. 2004. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. Journal of Biological Chemistry 279(37): 38563-70.
7. Edwards, Fred H., Victor A. Ferraris, David M. Shahian, Eric Peterson, Anthony P. Furnary, Constance K. Haan, and Charles R. Bridges. 2005. Gender-specific practice guidelines for coronary artery bypass surgery: perioperative management. Annals of Thoracic Surgery 79: 2189-94.
8. European Medicines Agency, 2005. ICH gender considerations in the conduct of clinical trials. EMEA/ CHMP/3916/2005. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/document/document_ detail.jsp?webContentId=WC500059887&murl=menus/document_library/document_library.jsp&mid=W C0b01ac058009a3dc. (13/02/2011)
9. Eyding, Dirk, Monika Lelgemann, Ulrich Grouven, Martin Härter, Mandy Kromp, Thomas Kaiser, Michaela F. Kerekes, Martin Gerken, and Beate Wieseler. 2010. Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. British Medical Journal 341: c4737.
10. Fisher, Jill A., and Lorna M. Ronald. 2010. Sex, gender, and pharmaceutical politics: from drug development to marketing. Gender Medicine 7(4): 357-70.
11. Fowler, Robert A., Natasha Sabur, Ping Li, David N. Juurlink, Ruxandra Pinto, Michelle A. Hladunewich, Neill K.J. Adhikari, William J. Sibbald, and Claudio M. Maritin. 2007. Sex-and age-based differences in the delivery and outcomes of critical care. Canadian Medical Association Journal 177(12): 1513-9.
12. Fowler, Robert A., Woganee Filate, Michael Hartleib, David W. Frodt, Chris Lazongas, and Michelle Hladunewich. 2009. Sex and critical illness. Current Opinion in Critical Care 15: 442-9.
13. genSET. 2010. Recommendations for action on the gender dimension in science. Consensus report produced by a panel of 14 European science leaders as part of the FP7 SiS funded genSET project. http://www. genderinscience.org/downloads/genSET_Consensus_Report_Recommendations_for_Action_on_the_ Gender_Dimension_in_Science.pdf.
14. Greenspan, Joel D., Rebecca M. Craft, Linda LeResche, Lars Arendt-Nielsen, Karen J. Berkley, Roger B. Fillingim, Michael S. Gold, Anita Holdcroft, Stefan Lautenbacher, Emeran A. Mayer, Jeffrey S. Mogil, Anne Z. Murphy, Richard J. Traub, and the Consensus Working Group of the Sex, Gender and Pain SIG of the IASP. 2007. Studying sex and gender differences in pain and analgesia: A consensus report. Pain 132: S26-45.
15. Groves, Trish. 2010. Evidence debased medicine. British Medical Journal 340: 786.
16. Gigerenzer, Gerd, Odette Wegwarth, and Markus Feufel Markus. 2010. Misleading communication of risk. British Medical Journal 341: c4830.
17. Goldsmith, Megan R., Clare R. Bankhead, and Joan Austoker. 2007. Synthesising quantitative and qualitative research in evidence-based patient information. Journal of Epidemiology and Community Health 61: 262-70.
18. Greyson, Devon L., Annelies R.E. Becu, and Steven G. Morgan. 2010. Sex, drugs and gender roles: mapping the use of sex and gender based analysis in pharmaceutical policy research. International Journal for Equity in Health 9: 26.
19. Harding, Sandra. 1995. 'Strong Objectivity': a response to the new objectivity question. Synthese 104: 331-49.
20. Health Canada. 1997. Inclusion of women in clinical trials. Therapeutic products programme guidelines. http://www.hc-sc.gc.ca/dhp-mps/prodpharma/applic-demande/guide-ld/clini/womct_femec-eng.php. (13/02/2011)
21. Holdcroft, Anita, and Karen J. Berkley. 2006. Sex and gender differences in pain and its relief. In the 5th Edition of the Wall and Melzack's Textbook of Pain, ed. S. McMahon and M. Koltzenburg, Chapter 75, 1181-97. Edinburgh: Churchill Livingstone.
22. Holdcroft, Anita. 2007a. Gender bias in research: how does it affect evidence based medicine? Journal of the Royal Society of Medicine 100: 2-3.
23. Holdcroft, Anita. 2007b. Integrating the dimensions of sex and gender into basic life sciences research: Methodologic and ethical issues. Gender Medicine 4(Suppl B): S64-S74.
24. Johnson, Joy I., Lorraine Greaves, and Robin Repta. 2009. Better science with sex and gender: facilitating the use of a sex and gender-based analysis in health research. International Journal for Equity in Health 8: 14.
25. Keuken, Debby G., Joke A. Haafkens, Marian J. Hellema, Jako S. Burgers, and Clara J. Moerman. 2007. Incorporating a gender perspective into the development of clinical guidelines: a training course for guideline developers. Implementation Science 2: 25.
26. Kim, Alison M., Candace M. Tingen, and Teresa K. Woodruff. 2010. Sex bias in trials and treatment must end. Nature 465: 688-9.
27. Kim, Hyungsuk, David Clark, and Raymond A. Dionner. 2009. Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research. Journal of Pain 7: 663-93.
28. Klinge, Ineke. 2007. Bringing gender expertise to biomedical and health-related research. Gender Medicine, 4(Suppl B): S59-S63.
29. Loder, Elizabeth, and Fiona Godlee. 2010. Missing clinical trial data: setting the record straight. Urgent action is needed to restore the integrity of the medical evidence base. British Medical Journal 34: c5641.
30. McAlister, Finlay A., Sean van Diepen, Rajdeep S. Padwal, Jeffrey A. Johnson, and Sumit R. Majumdar. 2007. How evidence-based are the recommendations in evidence-based guidelines? PLoS Med 4(8): e250.
31. Nakajima, Kenichi, Koichi Okuda, Masaya Kawano, Shinro Matsuo, Piots Slomka, Guido Germano, and Seigo Kinuya. 2009. The importance of population-specific normal database for quantification of myocardial ischemia: comparison between Japanese 360 and 180-degree databases and a US database. Journal of Nuclear Cardiology 16(3): 422-30.
32. National Institutes of Health 1994. Department of Health and Human Services NIH guidelines on the inclusion of women and minorities as subjects in clinical research. Bethesda, MD: NIH. http://grants. nih.gov/grants/guide/notice-files/not94-100.html. (13/02/2011)
33. Nichols, Francine H. 2000. History of the Women's Health Movement in the twentieth century. Journal of Obstetric, Gynecologic and Neonatal Nursing 29: 56-64.
34. Pankevich, Diana E., Theresa Wizemann, and Bruce M. Altevogt (rapporteurs). 2011. Sex differences and implications for translational neuroscience research. Workshop Summary, Institute of Medicine. Washington DC: The National Academies Press.
35. Pilote, Louise, Kaberu Dasgupta, Veena Guru, Karin H. Humphries, Jennifer McGrath, Colleen Norris, Doreen Rabi, Johanne Tremblay, Arsham Alamian, Tracie Barnett, Jafna Cox, William A. Ghali, Sherry Grace, Pavel Hamet, Teresa Ho, Susan Kirkland, Marie Lambert, Danielle Libersan, Jennifer O. Loughlin, Gilles Paradis, Milan Petrovich, and Vicky Tagalakis. 2007. A comprehensive view of sex-specific issues related to cardiovascular disease. Canadian Medical Association Journal 176(6): S1-44.
36. Raine, Rosalind, Caroline Goldfrad, Rowan Kathy, and Nick Black. 2002. Inß uence of patient gender on admission to intensive care. Journal of Epidemiology and Community Health 56: 418-23.
37. Rochon, Paula A., Jocalyn P. Clark, Malcolm A. Binns, Vishal Patel, and Jerry H. Gurwitz. 1998. Reporting of gender-related information in clinical trials of drug therapy for myocardial infarction. Canadian Medical Association Journal 159: 321-7.
38. Sackett, David L., William M.C. Rosenberg, Muir J.A. Gray, Brian R. Haynes, and Scott W. Richardson. 1996. Evidence based medicine: what it is and what it isn.t. British Medical Journal 312: 71-72.
39. Schiebinger, Londa. 2010. Gender, science and technology. United Nations Division for the Advancement of Women and the United Nations Educational, Scientific and Cultural Organisation. EGM/ST/2010/BP, 1 October 2010, Paris, France. http://www.stanford.edu/group/gender/cgi-bin/ wordpressblog/2010/10/londa-schiebinger-keynotes-un-conference-on-gender-science-and-technology. (13/02/2011)
40. Snidvongs, Saowarat, and Anita Holdcroft. 2010. How women respond to analgesics. MIMS Women's Health 5(3): 37-9.
41. Wijchers, Patrick J., Cihangir Yandim, Eleni Panousopoulou, Mushfika Ahmed, Nicky Harker, Alexander Saveliev, Paul S. Burgoyne, and Richard Festenstein. 2009. Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome compliment as well. Developmental Cell 14(19): 477-84.
42. World Health Organisation. 2009. Women and health. Today's evidence tomorrow's agenda. http://whqlibdoc. who.int/publications/2009/9789241563857_eng.pdf. (22/01/2011)