Localisation of human papillomavirus 16 E7 oncoprotein changes with cell confluence

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Laurson, Joanna ^a   Raj, Kenneth ^a,b  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN E7;

ARTICLE; CELL CULTURE; CELL CYCLE PHASE; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNOCYTOCHEMISTRY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; WESTERN BLOTTING; CELL CYCLE; CELL LINE; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM;

HUMAN PAPILLOMAVIRUS - 16; HUMAN PAPILLOMAVIRUS TYPE 16;

BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL NUCLEUS; CYTOPLASM; HUMAN PAPILLOMAVIRUS 16; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, FLUORESCENCE; PAPILLOMAVIRUS E7 PROTEINS;

EID: 79959651982     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021501     Document Type: Article

References (30)

1. Dürst M, Gissmann L, Ikenberg H, zur Hausen H, (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A 80: 3812-3815.
2. Gissmann L, Boshart M, Dürst M, Ikenberg H, Wagner D, et al. (1984) Presence of human papillomavirus in genital tumors. J. Invest. Dermatol 83: 26s-28s.
3. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR, Schiller JT, (1989) HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 8: 3905-3910.
4. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM, (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136.
5. Hubbert NL, Sedman SA, Schiller JT, (1992) Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. J Virol 66: 6237-6241.
6. Klingelhutz AJ, Foster SA, McDougall JK, (1996) Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380: 79-82 doi:10.1038/380079a0.
7. Veldman T, Horikawa I, Barrett JC, Schlegel R, (2001) Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol 75: 4467-4472 doi:10.1128/JVI.75.9.4467-4472.2001.
8. Dyson N, Howley PM, Münger K, Harlow E, (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934-937.
9. Nguyen CL, Eichwald C, Nibert ML, Münger K, (2007) Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. J Virol 81: 13533-13543 doi:10.1128/JVI.01669-07.
10. Smotkin D, Wettstein FO, (1987) The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein. J Virol 61: 1686-1689.
11. Greenfield I, Nickerson J, Penman S, Stanley M, (1991) Human papillomavirus 16 E7 protein is associated with the nuclear matrix. Proc Natl Acad Sci U S A 88: 11217-11221.
12. Zatsepina O, Braspenning J, Robberson D, Hajibagheri MA, Blight KJ, et al. (1997) The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells. Oncogene 14: 1137-1145 doi:10.1038/sj.onc.1200946.
13. Huh K-W, DeMasi J, Ogawa H, Nakatani Y, Howley PM, et al. (2005) Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600. Proc Natl Acad Sci U S A 102: 11492-11497 doi:10.1073/pnas.0505337102.
14. Jeon JH, Shin DM, Cho SY, Song KY, Park NH, et al. (2007) Immunocytochemical detection of HPV16 E7 in cervical smear. Exp Mol Med 39: 621-628.
15. Ressler S, Scheiden R, Dreier K, Laich A, Müller-Holzner E, et al. (2007) High-risk human papillomavirus E7 oncoprotein detection in cervical squamous cell carcinoma. Clin Cancer Res 13: 7067-7072 doi:10.1158/1078-0432.CCR-07-1222.
16. Dreier K, Scheiden R, Lener B, Ehehalt D, Pircher H, et al. (2011) Subcellular localization of the human papillomavirus 16 E7 oncoprotein in CaSki cells and its detection in cervical adenocarcinoma and adenocarcinoma in situ. Virology 409: 54-68 doi:10.1016/j.virol.2010.09.024.
17. Angeline M, Merle E, Moroianu J, (2003) The E7 oncoprotein of high-risk human papillomavirus type 16 enters the nucleus via a nonclassical Ran-dependent pathway. Virology 317: 13-23.
18. Knapp AA, McManus PM, Bockstall K, Moroianu J, (2009) Identification of the nuclear localization and export signals of high risk HPV16 E7 oncoprotein. Virology 383: 60-68 doi:10.1016/j.virol.2008.09.037.
19. Friedl F, Kimura I, Osato T, Ito Y, (1970) Studies on a new human cell line (SiHa) derived from carcinoma of uterus. I. Its establishment and morphology. Proc Soc Exp Biol Med 135: 543-545.
20. Pattillo RA, Hussa RO, Story MT, Ruckert AC, Shalaby MR, et al. (1977) Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line. Science 196: 1456-1458.
21. Stanley MA, Browne HM, Appleby M, Minson AC, (1989) Properties of a non-tumorigenic human cervical keratinocyte cell line. Int J Cancer 43: 672-676.
22. Allen-Hoffmann BL, Schlosser SJ, Ivarie CA, Sattler CA, Meisner LF, et al. (2000) Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J Invest Dermatol 114: 444-455 doi:10.1046/j.1523-1747.2000.00869.x.
23. Hoffmann R, Hirt B, Bechtold V, Beard P, Raj K, (2006) Different modes of human papillomavirus DNA replication during maintenance. J Virol 80: 4431-4439 doi:10.1128/JVI.80.9.4431-4439.2006.
24. Smith-McCune K, Kalman D, Robbins C, Shivakumar S, Yuschenkoff L, et al. (1999) Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Proc Natl Acad Sci U S A 96: 6999-7004.
25. Sato H, Watanabe S, Furuno A, Yoshiike K, (1989) Human papillomavirus type 16 E7 protein expressed in Escherichia coli and monkey COS-1 cells: immunofluorescence detection of the nuclear E7 protein. Virology 170: 311-315.
26. Dantur K, Alonso L, Castaño E, Morelli L, Centeno-Crowley JM, et al. (2009) Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: the amyloid-cancer connection. Int J Cancer 125: 1902-1911 doi:10.1002/ijc.24579.
27. Wolff B, Sanglier JJ, Wang Y, (1997) Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol 4: 139-147.
28. Baldwin A, Huh K-W, Münger K, (2006) Human papillomavirus E7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function. J Virol 80: 6669-6677 doi:10.1128/JVI.02497-05.
29. Barrow-Laing L, Chen W, Roman A, (2010) Low- and high-risk human papillomavirus E7 proteins regulate p130 differently. Virology 400: 233-239 doi:10.1016/j.virol.2010.01.034.
30. Todaro GJ, Green H, (1963) Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17: 299-313.