Endothelial damage after resuscitation: Reactive oxygen species as possible therapeutic targets?

Critical Care Medicine

Volumn 39, Issue 7, 2011, Pages 1837-1839

  Totzeck, Matthias ^a   Kelm, Malte ^a   Rassaf, Tienush ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

cardiac arrest; cardiopulmonary resuscitation; endothelial dysfunction; hydroxyl radicals; nitrite; reactive oxygen species

Indexed keywords

GLUTATHIONE; NITRIC OXIDE; NITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ARTERY ENDOTHELIUM; BRAIN INJURY; CELL CULTURE; CIRCULATION; EDITORIAL; HEART ARREST; HEART MUSCLE REPERFUSION; HUMAN; HYPOXIA; ISCHEMIA; MORBIDITY; MORTALITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PRIORITY JOURNAL; REPERFUSION; RESUSCITATION;

EID: 79959644603     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31821b8180     Document Type: Editorial

References (20)

1. Neumar RW, Nolan JP, Adrie C, et al: Postcardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008; 118: 2452-2483
2. Eisenberg MS, Mengert TJ: Cardiac resuscitation. N Engl J Med 2001; 344:1304-1313 (Pubitemid 32372965)
3. Eisenberg MS, Psaty BM: Cardiopulmonary resuscitation: Celebration and challenges. JAMA 2010; 304:87-88
4. Nichol G, Thomas E, Callaway CW, et al: Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA 2008; 300:1423-1431
5. Negovsky VA: Postresuscitation disease. Crit Care Med 1988; 16:942-946
6. Adrie C, Adib-Conquy M, Laurent I, et al: Successful cardiopulmonary resuscitation after cardiac arrest as a 'sepsis-like' syndrome. Circulation 2002; 106:562-568 (Pubitemid 34827705)
7. Cerchiari EL, Safar P, Klein E, et al: Vis- ceral, hematologic and bacteriologic changes and neurologic outcome after cardiac arrest in dogs. The visceral postresuscitation syndrome. Resuscitation 1993; 25:119-136 (Pubitemid 23123636)
8. Adams JA: Endothelium and cardiopulmonary resuscitation. Crit Care Med 2006; 34(Suppl):S458-S465 (Pubitemid 44772682)
9. Yellon DM, Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135
10. Zweier JL: Measurement of superoxidederived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury. J Biol Chem 1988; 263: 1353-1357 (Pubitemid 18039938)
11. Hendgen-Cotta UB, Merx MW, Shiva S, et al: Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Nat Acad Sci U S A 2008; 105: 10256-10261
12. Huet O, Dupic L, Batteux F, et al: Post-resuscitation syndrome: Potential role of hydroxyl radical-induced endothelial cell damage. Crit Care Med 2011; 39: 1712-1720
13. Celermajer DS, Sorensen KE, Gooch VM, et al: Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-1115
14. Zweier JL, Kuppusamy P, Williams R, et al: Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J Biol Chem 1989; 264: 18890-18895 (Pubitemid 19285787)
15. Murphy E, Steenbergen C: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 2008; 88:581-609 (Pubitemid 351520088)
16. Kleinbongard P, Dejam A, Lauer T, et al: Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 2003; 35:790-796 (Pubitemid 37329482)
17. Zweier JL, Wang P, Samouilov A, et al: Enzyme- independent formation of nitric oxide in biological tissues. Nat Med 1995; 1:804-809
18. Cosby K, Partovi KS, Crawford JH, et al: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003; 9:1498-1505 (Pubitemid 38004777)
19. Rassaf T, Flogel U, Drexhage C, et al: Nitrite reductase function of deoxymyoglobin: Oxygen sensor and regulator of cardiac energetic and function. Circ Res 2007; 100: 1749-1754 (Pubitemid 46987867)
20. Dezfulian C, Shiva S, Alekseyenko A, et al: Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I. Circulation 2009; 120:897-905