MUC2 is a highly specific marker of goblet cell metaplasia in the distal esophagus and gastroesophageal junction

American Journal of Surgical Pathology

Volumn 35, Issue 7, 2011, Pages 1007-1013

  McIntire, Maria G ^a,b   Soucy, Genevieve ^a,b   Vaughan, Thomas L ^c,d   Shahsafaei, Aliakbar ^a,b   Odze, Robert D ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Barrett esophagus; GEJ; intestinal metaplasia; metaplasia; MUC

Indexed keywords

BIOLOGICAL MARKER; MUC2 PROTEIN, HUMAN; MUCIN 2;

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; BIOPSY; COMPARATIVE STUDY; FEMALE; GASTROESOPHAGEAL REFLUX; GOBLET CELL; HUMAN; LOWER ESOPHAGUS SPHINCTER; MALE; METABOLISM; METAPLASIA; MIDDLE AGED; MUCOSA; PATHOLOGY; PREDICTIVE VALUE;

ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; BIOLOGICAL MARKERS; BIOPSY; ESOPHAGOGASTRIC JUNCTION; FEMALE; GASTROESOPHAGEAL REFLUX; GOBLET CELLS; HUMANS; MALE; METAPLASIA; MIDDLE AGED; MUCIN-2; MUCOUS MEMBRANE; PREDICTIVE VALUE OF TESTS;

EID: 79959641206     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318218940d     Document Type: Article

References (40)

1. Ajioka Y, Allison LJ, Jass JR. Significance of MUC1 and MUC2 mucin expression in colorectal cancer. J Clin Pathol. 1996;49:560-564. (Pubitemid 26232730)
2. Arul GS, Moorghen M, Myerscough N, et al. Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study. Gut. 2000;47:753-761.
3. Chandrasoma PT, Der R, Dalton P, et al. Distribution and significance of epithelial types in columnar-lined esophagus. Am J Surg Pathol. 2001;25:1188-1193. (Pubitemid 32777719)
4. Chandrasoma PT, Der R, Ma Y, et al. Histologic classification of patients based on mapping biopsies of the gastroesophageal junction. Am J Surg Pathol. 2003;27:929-936. (Pubitemid 36758896)
5. Chang SK, Dohrman AF, Basbaum CB, et al. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology. 1994;107:28-36. (Pubitemid 24195342)
6. Chaves P, Cardoso P, de Almeida JC, et al. Non-goblet cell population of Barrett's esophagus: an immunohistochemical demonstration of intestinal differentiation. Hum Pathol. 1999;30: 1291-1295. (Pubitemid 29534289)
7. Chaves P, Cruz C, Dias Pereira A, et al. Gastric and intestinal differentiation in Barrett's metaplasia and associated adenocarcinoma. Dis Esophagus. 2005;18:383-387. (Pubitemid 43904766)
8. Chaves P, Crespo M, Ribeiro C, et al. Chromosomal analysis of Barrett's cells: demonstration of instability and detection of the metaplastic lineage involved. Mod Pathol. 2007;20:788-796. (Pubitemid 46933442)
9. Chinyama CN, Marshall REK, Owen WJ, et al. Expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma: an immunopathological study with clinical correlation. Histopathology. 1999;35:517-524. (Pubitemid 30005377)
10. Edelstein MS, Bronner MP, Rosen SN, et al. Risk factors for Barrett's esophagus among patients with gastroesophageal reflux disease: a community clinic-based case-control study. Am J Gastroenterol. 2009;104:834-842.
11. Endo T, Tamaki K, Arimura Y, et al. Expression of sulfated carbohydrate chain and core peptides of mucin detected by monoclonal antibodies in Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol. 1998;33:811-815. (Pubitemid 29271541)
12. Flucke U, Steinborn E, Dries V, et al. Immunoreactivity of cytokeratins (CK7, CK20) and mucin peptide core antigens (MUC1, MUC2, MUC5AC) in adenocarcinomas, normal and metaplastic tissues of the distal oesophagus, oesophago-gastric junction and proximal stomach. Histopathology. 2003;43:127-134. (Pubitemid 36963156)
13. Gatenby PA, Ramus JR, Caygill CP, et al. Relevance of the detection of intestinal metaplasia in non-dysplastic columnar-lined oesophagus. Scand J Gastroenterol. 2008;43:524-530. (Pubitemid 351536041)
14. Gendler SJ, Spicer AP. Epithelial mucin genes. Annu Rev Physiol. 1995;57:607-634.
15. Glickman JN, Fox V, Antonioli DA, et al. Morphology of the cardia and significance of carditis in pediatric patients. Am J Surg Pathol. 2002;26:1032-1039. (Pubitemid 34810564)
16. Glickman JN, Shahsafaei A, Odze RD. Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach. Am J Surg Pathol. 2003;27:1357-1365. (Pubitemid 37185827)
17. Glickman JN, Blount PL, Sanchez CA, et al. Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus. Hum Pathol. 2006;37:1304-1315. (Pubitemid 44380275)
18. Guillem P, Billeret V, Buisine MP, et al. Mucin gene expression and cell differentiation in human normal, premalignant, and malignant esophagus. Int J Cancer. 2000;88:856-861.
19. Gum JR, Hicks JWQ, Toribara NW, et al. The human MUC2 intestinal mucin as cysteine-rich subdomains located both upstream and downstream of its central repetitive region. J Biol Chem. 1992; 267:1375-1383.
20. Hahn HP, Blount PL, Ayub K, et al. Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus. Am J Surg Pathol. 2009;33:1006-1015.
21. Harrison R, Perry I, Haddadin W, et al. Detection of intestinal metaplasia in Barrett's esophagus: an observational comparator study suggests the need for a minimum of eight biopsies. Am J Gastroenterol. 2007;102:1154-1161. (Pubitemid 46802035)
22. Jass JR. Mucin core proteins as differentiation markers in the gastrointestinal tract. Histopathology. 2000;37:561-564. (Pubitemid 32099168)
23. Jones TF, Sharma P, Daaboul B, et al. Yield of intestinal metaplasia in patients with suspected short-segment Barrett's esophagus (SSBE) on repeat endoscopy. Dig Dis Sci. 2002;47:2108-2111. (Pubitemid 35024831)
24. Kelty C, Gough M, Van Wyk Q. Barrett's oesophagus: intestinal metaplasia is not essential for cancer risk. Scand J Gastroenterol. 2007;42:1271-1274. (Pubitemid 47537076)
25. Liu W, Hahn H, Odze RD, et al. Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell containing epithelium. Am J Gastroenterol. 2009;104:816-824.
26. Oberg S, Johansson J, Wenner J, et al. Endoscopic surveillance of columnar-lined esophagus: frequency of intestinal metaplasia detection and impact of antireflux surgery. Ann Surg. 2001;234:619-626. (Pubitemid 33041764)
27. Odze RD. Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective. Am J Gastroenterol. 2005;100:1853-1867. (Pubitemid 41648443)
28. Ogiya K, Kawano T, Ito E, et al. Lower esophageal palisade vessels and the definition of Barrett's esophagus. Dis Esophagus. 2008;21: 645-649.
29. Piazuelo MD, Haque S, Delgado A, et al. Phenotypic differences between esophageal and gastric intestinal metaplasia. Mod Pathol. 2004;17:62-74. (Pubitemid 41656454)
30. Playford RJ. New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett's oesophagus. Gut. 2006;55:442.
31. Riddell RH, Odze RD. Definition of Barrett's esophagus: Time for a rethink-is intestinal metaplasia dead? Am J Gastroenterol. 2009;104: 2588-2594.
32. Romagnoli S, Roncalli M, Graziani D, et al. Molecular alterations of Barrett's esophagus on microdissected endoscopic biopsies. Lab Invest. 2001;81:241-247. (Pubitemid 32176388)
33. Spechler SJ. Barrett's esophagus. N Engl J Med. 2002;346:836-842. (Pubitemid 34984658)
34. Srivastava A, Odze RD, Lauwers GY, et al. Morphologic features are useful in distinguishing Barrett's esophagus from carditis with intestinal metaplasia. Am J Surg Pathol. 2007;31:1733-1741. (Pubitemid 350287572)
35. Takubo K, Aida J, Naomoto Y, et al. Cardiac rather than intestinaltype background in endoscopic resection specimens of minute Barrett's adenocarcinoma. Hum Pathol. 2009;40:65-74.
36. Wang DH, Souza RF. Biology of Barrett's esophagus and esophageal adenocarcinoma. Gastrointest Endoscopy Clin N Am. 2001;21:25-38.
37. Wang KK, Sampliner RE. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus. Am J Gastroenterol. 2008;103:788-797. (Pubitemid 351406009)
38. Warson C, Van De Bovemkamp JH, Korteland-van Male AM, et al. Barrett's esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. Hum Pathol. 2002;22:660-668. (Pubitemid 34827549)
39. Winterford CM, Walsh MD, Leggett BA, et al. Ultrastructural localisation of epithelial mucin core proteins in colorectal tissues. J Histochem Cytochem. 1999;47:1063-1074. (Pubitemid 29379906)
40. Yamamoto S, Kijima H, Hara T, et al. Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. Int J Mol Med. 2005;16:375-380.