Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach

American Journal of Surgical Pathology

Volumn 27, Issue 10, 2003, Pages 1357-1365

  Glickman, Jonathan N ^a   Shahsafaei, Aliakbar ^b   Odze, Robert D ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

Barrett's esophagus; Intestinal metaplasia; Mucins

Indexed keywords

ADULT; ANTIBODY DETECTION; ARTICLE; BARRETT ESOPHAGUS; CANCER RISK; CARDIA; CARDITIS; CLINICAL ARTICLE; CLINICAL FEATURE; COLUMNAR EPITHELIUM; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; EVALUATION; FEMALE; GOBLET CELL; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINE BIOPSY; INTESTINE METAPLASIA; MALE; PATHOLOGICAL ANATOMY; PHENOTYPE; PREVALENCE; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; STOMACH ANTRUM; STOMACH CANCER;

ANTIBODIES, MONOCLONAL; BARRETT ESOPHAGUS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; METAPLASIA; MIDDLE AGED; MUCINS; STOMACH; STOMACH DISEASES;

EID: 0141682705     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200310000-00008     Document Type: Article

References (40)

1. Ajioka Y, Allison LJ, Jass JR. Significance of MUC1 and MUC2 expression in colorectal cancer. J Clin Pathol. 1996;49:560-564.
2. Arul GS, Moorghen M, Myerscough N, et al. Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study. Gut. 2000;47:753-761.
3. Audie JP, Janin A, Porchet N, et al. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem. 1993;41:1479-1485.
4. Carrato C, Balague C, de Bolos C, et al. Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology. 1994;107:160-172.
5. Chandrasoma PT, Lokuhetty DM, Demeester TR, et al. Definition of histopathologic changes in gastroesophageal reflux disease. Am J Surg Pathol. 2000;24:344-351.
6. Chen YY, Antonioli DA, Spechler SJ, et al. Gastroesophageal reflux disease versus Helicobacter pylori infection as the cause of gastric carditis. Mod Pathol. 1998;11:950-956.
7. Chen Y-Y, Wang HH, Antonioli DA, et al. Significance of acid-mucin-positive nongoblet columnar cells in the distal esophagus and gastroesophageal junction. Hum Pathol. 1999;30:1488-1495.
8. Chinyama CN, Marshall REK, Owen WJ, et al. Expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma: an immunopathological study with clinical correlation. Histopathology. 1999;35:517-524.
9. Corfield AP, Myerscough N, Longman R, et al. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut. 2000;47:589-594.
10. Couvelard A, Cauvin JM, Goldfain D, et al. Groupe d'Etude l'Oesophage de Barrett: cytokeratin immunoreactivity of intestinal metaplasia at normal oesophagogastric junction indicates its aetiology. Gut. 2001;49:761-766.
11. Der R, Tsao-Wei DD, Demeester T, et al. Carditis: a manifestation of gastroesophageal reflux disease. Am J Surg Pathol. 2001;25:245-252.
12. Genta RM, Huberman RM, Graham DY. The gastric cardia in Helicobacter pylori infection. Hum Pathol. 1994;25:915-919.
13. Glickman JN, Wang H, Das KM, et al. Phenotype of Barrett's esophagus and intestinal metaplasia of the distal esophagus and gastroesophageal junction: an immunohistochemical study of cytokeratins 7 and 20, Das-1 and 45 M1. Am J Surg Pathol. 2001;25:87-94.
14. Glickman JN, Ormsby AH, Gramlich TR, et al. Interobserver variability in the interpretation of a Barrett's cytokeratin 7/20 immunoreactivity pattern. Gastroenterology. 2001;120:579A.
15. Glickman JN, Fox VL, Antonioli DA, et al. Morphology of the cardia and significance of carditis in pediatric patients. Am J Surg Pathol. 2002;26: 1032-1039.
16. Goldblum JR, Vicari JJ, Falk GW, et al. Inflammation and intestinal metaplasia of the gastric cardia: role of gastroesophageal reflux and H. pylori infection. Gastroenterology. 1998;114:633-639.
17. Guillem P, Billeret V, Buisine MP, et al. Mucin gene expression and cell differentiation in human normal, premalignant and malignant esophagus. Int J Cancer. 2000;88:856-861.
18. Haggitt RC, Reid BJ, Rabinovitch PS, et al. Barrett's esophagus: correlation between mucin histochemistry, flow cytometry and histologic diagnosis for predicting increased cancer risk. Am J Pathol. 1988;131:53-61.
19. Hirota WK, Loughney TM, Lazas DJ, et al. Specialized intestinal metaplasia, dysplasia, and cancer of the esophagus and esophagogastric junction: prevalence and clinical data. Gastroenterology. 1999;116:277-285.
20. Ho SB, Shekels LL, Toribara NW, et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995;55:2681-2690.
21. Jass JR. Mucin histochemistry of the columnar epithelium of the esophagus: a retrospective study. J Clin Pathol. 1981;34:866-870.
22. Jass JR. Mucin core proteins as differentiation markers in the gastrointestinal tract. Histopathology. 2000;37:561-564.
23. Kilgore SP, Ormsby AH, Gramlich TL, et al. The gastric cardia: fact or fiction? Am J Gastroenterol. 2000;95:921-924.
24. Lapertosa G, Baracchini P, Fulcheri E. Mucin histochemical analysis in the interpretation of Barrett's esophagus: results of a multicenter study. The Operative Group for the Study of Esophageal Precancer. Am J Clin Pathol. 1992;98:61-66.
25. Lee RG. Mucins in Barrett's esophagus: a histochemical study. Am J Clin Pathol. 1984;81:500-503.
26. Nandurkar S, Talley J. Barrett's Esophagus: the long and short of it. Am J Gastroenterol. 1999;94:30-40.
27. Oberg S, Peters JH, DeMeester TR, et al. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann Surg. 1997;226:522-532.
28. Ormsby AH, Goldblum JR, Rice TW, et al. Cytokeratin subsets can reliably distinguish Barrett's esophagus from intestinal metaplasia of the stomach. Hum Pathol. 1999;30:288-294.
29. Ormsby AH, Vaezi MF, Richter JE. Cytokeratin immunoreactivity patterns in the diagnosis of short-segment Barrett's esophagus. Gastroenterology. 2000;119:683-690.
30. Reis CA, David L, Correa P, et al. Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res. 1999;59:1003-1007.
31. Sampliner RE. Practice guidelines on the diagnosis, surveillance, and therapy of Barrett's esophagus: the Practice Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol. 1998;93: 1028-1032.
32. Sharma P, Weston AP, Morales T, et al. Relative risk of dysplasia for patients with intestinal metaplasia in the distal oesophagus and in the gastric cardia. Gut. 2000;46:9-13.
33. Spechler SJ, Zerrogian JM, Antonioli DA, et al. Prevalence of metaplasia at the gastro-oesophageal junction. Lancet. 1994;344:1533-1536.
34. Spechler S. The role of gastric carditis in metaplasia and neoplasia at the gastroesophageal junction. Gastroenterology. 1998; 117:218-228.
35. Spechler SJ. Barrett's esophagus. N Engl J Med. 2002;346:836-842.
36. Taylor-Papadimitriou J, Burchell J, Miles DW, et al. MUC1 and cancer. Biochim Biophys Acta. 1999;1455:301-313.
37. Torrado J, Ruiz B, Garay J, et al. Blood-group phenotypes, sulfomucins, and Helicobacter pylori in Barrett's esophagus. Am J Surg Pathol. 1997; 21:1023-1029.
38. Wallner B, Sylvan A, Janunger KG, et al. Immunohistochemical markers for Barrett's esophagus and associations to esophageal Z-line appearance. Scand J Gastroenterol. 2001;9:910-915.
39. Warson C, Van De Bovemkamp JH, Korteland-van Male AM, et al. Barrett's esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. Hum Pathol. 2002;33:660-668.
40. Winterford CM, Walsh MD, Leggett BA, et al. Ultrastructural localization of epithelial mucin core proteins in colorectal tissues. J Histochem Cytochem. 1999;47:1063-1074.