Bitumen workers handling mastic versus rolled asphalt in a tunnel: Assessment of exposure and biomarkers of irritation and genotoxicity

Archives of Toxicology

Volumn 85, Issue SUPPL. 1, 2011, Pages

  Raulf Heimsoth, Monika ^a   Marczynski, Boleslaw ^a   Spickenheuer, Anne ^a   Pesch, Beate ^a   Welge, Peter ^a   Rühl, Reinhold ^c   Bramer, Rainer ^a   Kendzia, Benjamin ^a   Heinze, Evelyn ^a   Angerer, Jürgen ^a,b   Brüning, Thomas ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c BG BAU   (Germany)

Author keywords

Bitumen; Genotoxic biomarkers; Mastic asphalt; PAH metabolites; Rolled asphalt; Spirometry

Indexed keywords

1 HYDROXYPYRENE; ASPHALT; BIOLOGICAL MARKER; DNA; PHENANTHRENE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ACUTE TOXICITY; ADOLESCENT; ADULT; AEROSOL; AIRBORNE PARTICLE; ARTICLE; CONCENTRATION (PARAMETERS); CONSTRUCTION WORK; CONTROLLED STUDY; DNA ADDUCT; DNA STRAND BREAKAGE; GENOTOXICITY; HUMAN; MAJOR CLINICAL STUDY; METABOLITE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SHIFT WORKER; SPIROMETRY; URINE LEVEL; VAPOR;

ADOLESCENT; ADULT; AEROSOLS; AIR POLLUTANTS, OCCUPATIONAL; BIOLOGICAL MARKERS; CONSTRUCTION MATERIALS; DNA ADDUCTS; DNA BREAKS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMPLOYMENT; ENVIRONMENTAL MONITORING; HUMANS; HYDROCARBONS; INHALATION EXPOSURE; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYCYCLIC HYDROCARBONS, AROMATIC; RESPIRATORY FUNCTION TESTS; RISK ASSESSMENT; VOLATILIZATION; YOUNG ADULT;

EID: 79959627245     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0685-2     Document Type: Article

References (19)

1. Bouchard M, Krishnan K, Vian C (1998) Kinetics of tissue distribution and elimination of pyrene and 1-hydroxypyrene following intravenous administration of [14c]pyrene in rats. Toxicol Sci 46:11-20 (Pubitemid 29014079)
2. Breuer D (2008) Bitumen (Dämpfe und Aeorosole, Mineralöl- Standard). BGIA Arbeitsmappe digital 6305/1
3. Breuer D, Hahn JU, Höber D, Emmel C, Musanke U, Rühl R, Spickenheuer A, Raulf-Heimsoth M, Bramer R, Seidel A, Schilling B, Heinze E, Kendzia B, Marczynski B, Welge P, Angerer J, Brüning T, Pesch B (2011) Air sampling, analytical methodology and measurement strategy for bitumen and polycyclic aromatic hydrocarbons vapours and aerosols. Arch Toxicol (in press)
4. Burstyn I, Kromhout H (2000) Are the members of a paving crew uniformly exposed to bitumen fume, organic vapour, and Benzo(a)pyrene? Risk Anal 20:653-663
5. Deutsche Forschungsgemeinschaft (2003) Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Luftanalysen. Polycyclische aromatische Kohlenwasserstoffe (PAH). Meth.-Nr. 3 PAH. [Hrsg.: Greim, H] Wiley-VCH, Weinheim. 13. Lieferung
6. Lintelmann J, Angerer J (1999) PAH metabolites. In: Angerer J, Schaller KH (eds) Analysis of hazardous substances in biological materials, vol 6. Wiley-VCH, Weinheim, pp 163-187
7. Marczynski B, Rihs HP, Rossbach B, Hölzer J, Angerer J, Scherenberg M, Hoffmann G, Brüning T, Wilhelm M (2002) Analysis of 8-oxo-7, 8-dihydro-2′-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis 23:273-281 (Pubitemid 34224002)
8. Marczynski B, Raulf-Heimsoth M, Preuss R, Kappler M, Schott K, Pesch B, Zoubek G, Hahn JU, Mensing T, Angerer J, Käfferlein HU, Brüning T (2006) Assessment of DNA damage in WBCs of workers occupationally exposed to fumes and aerosols of bitumen. Cancer Epidemiol Biomarkers Prev 15:645-651
9. Marczynski B, Raulf-Heimsoth M, Spickenheuer A, Pesch B, Kendzia B, Mensing T, Engelhardt B, Lee EH, Schindler B, Heinze E, Welge P, Bramer R, Breuer D, Angerer J, Käfferlein HU, Brüning T (2011) DNA adducts and strand breaks in workers exposed to vapours and aerosols of bitumen: association between exposure and effect. Arch Toxicol (in press)
10. NIOSH (2000) Health effects of occupational exposure to asphalt. NIOSH-Publications Dissemination, Cincinnati
11. Östling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commu 123:291-298 (Pubitemid 14030137)
12. Pesch B, Spickenheuer A, Kendzia B, Schindler BK, Welge P, Marczynski B, Rihs HP, Raulf-Heimsoth M, Angerer J, Brüning T (2011) Urinary metabolites of polycyclic aromatic hydrocarbons in workers exposed to vapours and aerosols of bitumen. Arch Toxicol (in press)
13. Raulf-Heimsoth M, Angerer J, Pesch B, Marczynski B, Hahn JU, Spickenheuer A, Preuss R, Rühl R, Rode P, Brüning T (2008) Biological monitoring as a useful tool for the detection of a coal-tar contamination in bitumen-exposed workers. J Toxicol Environ Health 71:746-750 (Pubitemid 351999196)
14. Raulf-Heimsoth M, Pesch B, Rühl R, Brüning T (2011a) The human Bitumen study: executive summary. Arch Toxicol (in press)
15. Raulf-Heimsoth M, Pesch B, Kendzia B, Spickenheuer A, Bramer R, Marczynski B, Merget R, Brüning T (2011b) Irritative effects of vapours and aerosols of bitumen on the airways assessed by non-invasive methods. Arch Toxicol (in press)
16. Rojas M, Alexandrov K, Cascorbi I, Brockmöller J, Likhachev A, Pozharisski K, Bouvier G, Auburtin G, Mayer L, Kopp-Schneider A, Roots I, Bartsch H (1998) High benzo[a]pyrene diol epoxide DNA adduct levels in lung and blood cells from subjects with combined CYP1A1 MspI/Msp/I-GSTM1*0/*0 genotypes. Pharmacogenetics 8:109-118 (Pubitemid 28227318)
17. Rühl R, Musanke U, Kolmsee K, Prieß R, Zoubek G, Breuer D (2006) Vapours and aerosols of bitumen: exposure data obtained by the German Bitumen Forum. Ann Occup Hyg 50:459-468 (Pubitemid 44306029)
18. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
19. Spickenheuer A, Rühl R, Höber D, Raulf-Heimsoth M, Marczynski B, Welge P, Breuer D, Gabriel S, Musanke U, Rode P, Heinze E, Kendzia B, Bramer R, Knecht U, Hahn JU, Brüning T, Pesch B (2011) Levels and determinants of exposure to vapours and aerosols of bitumen. Arch Toxicol (in press)