Prognostic implications of parathyroid hormone-related protein in males and females with non-small-cell lung cancer

Clinical Lung Cancer

Volumn 12, Issue 3, 2011, Pages 197-205

  Montgrain, Philippe R ^a   Deftos, Leonard J ^a   Arenberg, Douglas ^b   Tipps, Ann ^c   Quintana, Rick ^a   Carskadon, Shannon ^b   Hastings, Randolph H ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biochemical markers; Growth factors and receptor; Immunohistochemistry; Prognosis; Tumor biology

Indexed keywords

BIOLOGICAL MARKER; EPITOPE; PARATHYROID HORMONE RELATED PROTEIN; TUMOR PROTEIN;

AGED; ARTICLE; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PROGNOSIS; PROTEIN EXPRESSION; SEX DIFFERENCE; SURVIVAL RATE; SURVIVAL TIME;

EID: 79959620572     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2011.03.018     Document Type: Article

References (30)

1. Hastings RH, Laux AM, Casillas A, et al. Sex-specific survival advantage with PTHrP in non-small cell lung carcinoma patients [published erratum appears in: Clin Cancer Res 2006;12:4130]. Clin Cancer Res 2006; 12:499-506. (Pubitemid 43166141)
2. Nishigaki Y, Ohsaki Y, Toyoshima E, et al. Increased serum and urinary levels of a parathyroid hormone-related protein COOH terminus in non-small cell lung cancer patients. Clin Cancer Res 1999; 5:1473-81. (Pubitemid 29282955)
3. Abou-Samra AB, Juppner H, Force T, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A 1992; 89:2732-6.
4. Orloff JJ, Reddy D, de Papp AE, et al. Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions. Endocr Rev 1994; 15:40-60. (Pubitemid 24058595)
5. Zheng MH, McCaughan HB, Papadimitriou JM, et al. Tartrate resistant acid phosphatase activity in rat cultured osteoclasts is inhibited by a carboxyl terminal peptide (osteostatin) from parathyroid hormone-related protein. J Cell Biochem 1994; 54:145-53. (Pubitemid 24081044)
6. De Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, et al. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology 2001; 142:4096-105. (Pubitemid 32802683)
7. Goomer RS, Johnson KA, Burton DW, et al. The tetrabasic KKKK 147-150 motif determines intracrine regulatory effects of PTHrP 1-173 on chondrocyte PPi metabolism and matrix synthesis. Endocrinology 2000; 141:4613-22. (Pubitemid 32055140)
8. Luparello C, Sirchia R, Pupello D. PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression. J Cell Sci 2003; 116:2421-30. (Pubitemid 36790124)
9. Orloff JJ, Ganz MB, Nathanson MH, et al. A midregion parathyroid hormonerelated peptide mobilizes cytosolic calcium and stimulates formation of inositol trisphosphate in a squamous carcinoma cell line. Endocrinology 1996; 137:5376-85. (Pubitemid 26423099)
10. Henderson JE, Amizuka N, Warshawsky H, et al. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol 1995; 15:4064-75.
11. Hiraki A, Ueoka H, Bessho A, et al. Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia. Cancer 2002; 95:1706-13.
12. Pardo FS, Lien WW, Fox HS, et al. Parathyroid hormone-related protein expression is correlated with clinical course in patients with glial tumors. Cancer 2004; 101:2622-8. (Pubitemid 39532293)
13. Iwamura M, Wu M, Muramoto M, et al. Parathyroid hormone-related protein is an independent prognostic factor for renal cell carcinoma. Cancer 1999; 86:1028-34. (Pubitemid 29439858)
14. Henderson MA, Danks JA, Slavin JL, et al. Parathyroid hormone-related protein localization in breast cancers predict improved prognosis. Cancer Res 2006; 66: 2250-6.
15. Linforth R, Anderson N, Hoey R, et al. Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival. Clin Cancer Res 2002; 8:3172-7. (Pubitemid 35155027)
16. Deftos LJ, Burton DW, Brandt DW. Parathyroid hormone-like protein is a secretory product of atrial myocytes. J Clin Invest 1993; 92:727-35. (Pubitemid 23262391)
17. Hastings RH, Summers-Torres D, Cheung TC, et al. Parathyroid hormone-related protein, an autocrine regulatory factor for alveolar epithelial cells. Am J Physiol 1996; 270:L353-61.
18. Deftos LJ, Gazdar AF, Ikeda K, et al. The parathyroid hormone-related protein associated with malignancy is secreted by neuroendocrine tumors. Mol Endocrinol 1989; 3:503-8. (Pubitemid 19085047)
19. Bouvet M, Nardin SR, Burton DW, et al. Human pancreatic adenocarcinomas express parathyroid hormone-related protein. J Clin Endocrinol Metab 2001; 86: 310-6. (Pubitemid 32109811)
20. Takai E, Yano T, Iguchi H, et al. Tumor-induced hypercalcemia and parathyroid hormone-related protein in lung carcinoma. Cancer 1996; 78:1384-7. (Pubitemid 26317857)
21. Bruns ME, Ferguson JE 2nd, Bruns DE, et al. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function. Am J Obstet Gynecol 1995; 173:739-46.
22. Bhatia V, Mula RV, Weigel NL, et al. Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res 2009; 7:1119-31.
23. Bakre MM, Zhu Y, Yin H, et al. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med 2002; 8:995-1003. (Pubitemid 35033704)
24. Hastings RH, Montgrain PR, Quintana R, et al. Cell cycle actions of parathyroid hormone-related protein in non-small cell lung carcinoma. Am J Physiol Lung Cell Mol Physiol 2009; 297:L578-85.
25. Hastings RH, Burton DW, Quintana RA, et al. Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice. Cancer 2001; 92:1402-10. (Pubitemid 32947823)
26. Monego G, Lauriola L, Ramella S, et al. Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 expression in human lung adenocarcinoma. Chest 2010; 137:898-908.
27. Luparello C, Birch MA, Gallagher JA, et al. Clonal heterogeneity of the growth and invasive response of a human breast carcinoma cell line to parathyroid hormonerelated peptide fragments. Carcinogenesis 1997; 18:23-9. (Pubitemid 28134612)
28. Tsuchimochi M, Kameta A, Sue M, et al. Immunohistochemical localization of parathyroid hormone-related protein (PTHrP) and serum PTHrP in normocalcemic patients with oral squamous cell carcinoma. Odontology 2005; 93:61-71. (Pubitemid 41403560)
29. Gotoh A, Kitazawa S, Mizuno Y, et al. Common expression of parathyroid hormone- related protein and no correlation of calcium level in renal cell carcinomas. Cancer 1993; 71:2803-6. (Pubitemid 23120058)
30. Manenti G, Peissel B, Gariboldi M, et al. A cancer modifier role for parathyroid hormone-related protein. Oncogene 2000; 19:5324-8.