Slit-robo signaling in ocular angiogenesis

Advances in Experimental Medicine and Biology

Volumn 664, Issue , 2010, Pages 457-463

  Chen, Haoyu ^a,b   Zhang, Mingzhi ^c   Tang, Shibo ^c   London, Nyall R ^c   Li, Dean Y ^c   Zhang, Kang ^c  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

HETERODIMER; ROBO1 PROTEIN; ROBO4 PROTEIN; ROUNDABOUT RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

BLOOD VESSEL PERMEABILITY; CELL MIGRATION; CONFERENCE PAPER; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; HUMAN; NONHUMAN; OXYGEN INDUCED RETINOPATHY; PRIORITY JOURNAL; PROTEIN FUNCTION; RETINA NEOVASCULARIZATION; RETINOPATHY; SIGNAL TRANSDUCTION; SLIT ROBO SIGNALING; SUBRETINAL NEOVASCULARIZATION; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

ANIMALS; AXONS; EYE; GLYCOPROTEINS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 79959614886     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1399-9_52     Document Type: Conference Paper

References (23)

1. Adams RH (2006) Nerve cell signposts in the blood vessel roadmap. Circ Res 98:440-442
2. Bedell VM, Yeo SY, Park KW et al (2005) roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A 102:6373-6378 (Pubitemid 40617450)
3. Campochiaro PA, Hackett SF (2003) Ocular neovascularization: A valuable model system. Oncogene 22:6537-6548 (Pubitemid 37372333)
4. Dallol A, Forgacs E, Martinez A et al (2002) Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. Oncogene 21:3020-3028 (Pubitemid 34522901)
5. Friedman DS, O'Colmain BJ, Munoz B et al (2004) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122:564-572 (Pubitemid 38456293)
6. Gariano RF, Gardner TW (2005) Retinal angiogenesis in development and disease. Nature 438:960-966 (Pubitemid 43093962)
7. Hohenester E, Hussain S, Howitt JA (2006) Interaction of the guidance molecule slit with cellular receptors. Biochem Soc Trans 34:418-421 (Pubitemid 43954001)
8. Huminiecki L, Gorn M, Suchting S et al (2002) Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 79:547-552 (Pubitemid 34274296)
9. Jones CA, London NR, Chen H et al (2008) Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med 14:448-453 (Pubitemid 351499393)
10. Kaur S, Samant GV, Pramanik K et al (2008) Silencing of directional migration in roundabout4 knockdown endothelial cells. BMC Cell Biol 9:61
11. Kidd T, Brose K, Mitchell KJ et al (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92:205-215 (Pubitemid 28073044)
12. Li HS, Chen JH,WuWet al (1999) Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818 (Pubitemid 29165084)
13. Liu D, Hou J, Hu X et al (2006) Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Circ Res 98:480-489
14. Narayan G, Goparaju C, Arias-Pulido H et al (2006) Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer 5:16
15. Park KW, Morrison CM, Sorensen LK et al (2003) Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev Biol 261:251-267 (Pubitemid 36993830)
16. Rosenfeld PJ, Brown DM, Heier JS et al (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355:1419-1431 (Pubitemid 44511557)
17. Rothberg JM, Jacobs JR, Goodman CS et al (1990) Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev 4:2169-2187 (Pubitemid 120034523)
18. Seth P, Lin Y, Hanai J et al (2005) Magic roundabout, a tumor endothelial marker: Expression and signaling. Biochem Biophys Res Commun 332:533-541 (Pubitemid 40725009)
19. Sheldon H, Andre M, Legg JA et al (2009) Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleationpromoting factors. FASEB J 23:513-522
20. Suchting S, Heal P, Tahtis K et al (2005) Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. FASEB J 19:121-123 (Pubitemid 40069938)
21. Varma R, Macias GL, Torres M et al (2007) Biologic risk factors associated with diabetic retinopathy: The Los Angeles Latino Eye Study. Ophthalmology 114:1332-1340 (Pubitemid 47001493)
22. Wang B, Xiao Y, Ding BB et al (2003) Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4:19-29 (Pubitemid 36904158)
23. Zou HD, Zhang X, Xu X et al (2005) Prevalence study of age-related macular degeneration in Caojiadu blocks, Shanghai. Zhonghua Yan Ke Za Zhi 41:15-19