Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress

Pharmaceutical Biology

Volumn 49, Issue 8, 2011, Pages 856-863

  Jiang, Fengrong ^a,b   Qian, Jinchun ^a   Chen, Siyu ^a   Zhang, Wenbo ^a   Liu, Chang ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

atherosclerosis; dyslipidemia; Ligustrazine; oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MESSENGER RNA; TETRAMETHYLPYRAZINE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; FATTY ACID OXIDATION; FOOD INTAKE; GENE EXPRESSION; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIPID STORAGE; LIPOPROTEIN BLOOD LEVEL; LIVER; LIVER FUNCTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TASTE PREFERENCE; THORACIC AORTA; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; ATHEROSCLEROSIS; CHOLESTEROL; DIET, ATHEROGENIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; DYSLIPIDEMIAS; LIPID METABOLISM; LIVER; LIVER FUNCTION TESTS; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME; TRIGLYCERIDES; VASODILATOR AGENTS;

APIACEAE; LIGUSTICUM CHUANXIONG; RATTUS;

EID: 79959614289     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2010.551776     Document Type: Article

References (35)

1. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. (1986). Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA, 256, 2835-2838. (Pubitemid 17178361)
2. Chang Y, Hsiao G, Chen SH, Chen YC, Lin JH, Lin KH, Chou DS, Sheu JR. (2007). Tetramethylpyrazine suppresses HIF-1alpha, TNFalpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats. Acta Pharmacol Sin, 28, 327-333.
3. Clarke LA, Shah V, Arrigoni F, Eleftheriou D, Hong Y, Halcox J, Klein N, Brogan PA. (2008). Quantitative detection of circulating endothelial cells in vasculitis: Comparison of flow cytometry and immunomagnetic bead extraction. J Thromb Haemost, 6, 1025-1032. (Pubitemid 351689926)
4. Duprez DA, Cohn JN. (2007). Arterial stiffness as a risk factor for coronary atherosclerosis. Curr Atheroscler Rep, 9, 139-144. (Pubitemid 47376985)
5. Goldstein JL, Hazzard WR, Schrott HG, Bierman EL, Motulsky AG. (1973). Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest, 52, 1533-1543.
6. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA. (1989). Highdensity lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation, 79, 8-15. (Pubitemid 19043669)
7. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. (1977). High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med, 62, 707-714. (Pubitemid 8110784)
8. Hansson GK. (2009). Inflammatory mechanisms in atherosclerosis. J Thromb Haemost, 7 (Suppl 1), 328-331.
9. Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. (2000). Defect in peroxisome proliferator-activated receptor alphainducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem, 275, 28918-28928.
10. Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR Jr. (2008). Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA, 299, 2287-2293. (Pubitemid 351724395)
11. Hsiai T, Berliner JA. (2007). Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets, 8, 1222-1229.
12. Illingworth DR, Bacon S. (1987). Hypolipidemic effects of HMG-CoA reductase inhibitors in patients with hypercholesterolemia. Am J Cardiol, 60, 33G-42G. (Pubitemid 17164563)
13. Ishigaki Y, Oka Y, Katagiri H. (2009). Circulating oxidized LDL: A biomarker and a pathogenic factor. Curr Opin Lipidol, 20, 363-369.
14. Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK. (2002). Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. Exp Mol Med, 34, 137-144. (Pubitemid 34664330)
15. Kitagawa S, Yamaguchi Y, Kunitomo M, Imaizumi N, Fujiwara M. (1993). Altered vasoconstrictor responsiveness in vitamin D-induced arteriosclerotic rat aortas. Jpn J Pharmacol, 61, 283-289. (Pubitemid 23146220)
16. Kobayashi S, Inoue N, Azumi H, Seno T, Hirata K, Kawashima S, Hayashi Y, Itoh H, Yokozaki H, Yokoyama M. (2002). Expressional changes of the vascular antioxidant system in atherosclerotic coronary arteries. J Atheroscler Thromb, 9, 184-190.
17. Li YJ, Li YJ, Wu JX, Yu XJ, Yan YF. (1994). Protective effect of tetramethylpyrazine against damages of aortic endothelial cells elicited by low-density lipoproteins. Zhongguo Yao Li Xue Bao, 15, 407-410.
18. Lizardi-Cervera J, Aguilar-Zapata D. (2009). Nonalcoholic fatty liver disease and its association with cardiovascular disease. Ann Hepatol, 8 (Suppl 1), S40-S43.
19. Makin AJ, Chung NA, Silverman SH, Lip GY. (2003). Thrombogenesis and endothelial damage/dysfunction in peripheral artery disease. Relationship to ethnicity and disease severity. Thromb Res, 111, 221-226. (Pubitemid 38021939)
20. Muniyappa R, Montagnani M, Koh KK, Quon MJ. (2007). Cardiovascular actions of insulin. Endocr Rev, 28, 463-491. (Pubitemid 47236334)
21. Peng W, Hucks D, Priest RM, Kan YM, Ward JP. (1996). Ligustrazineinduced endothelium-dependent relaxation in pulmonary arteries via an NO-mediated and exogenous l-arginine-dependent mechanism. Br J Pharmacol, 119, 1063-1071. (Pubitemid 26366505)
22. Puddu GM, Cravero E, Arnone G, Muscari A, Puddu P. (2005). Molecular aspects of atherogenesis: New insights and unsolved questions. J Biomed Sci, 12, 839-853. (Pubitemid 43081666)
23. Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND. (2006). Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metab Clin Exp, 55, 928-934. (Pubitemid 43902895)
24. Seyama Y, Wachi H. (2004). Atherosclerosis and matrix dystrophy. J Atheroscler Thromb, 11, 236-245.
25. Singh U, Jialal I. (2006). Oxidative stress and atherosclerosis. Pathophysiology, 13, 129-142.
26. Soccio M, Toniato E, Evangelista V, Carluccio M, De Caterina R. (2005). Oxidative stress and cardiovascular risk: The role of vascular NAD(P)H oxidase and its genetic variants. Eur J Clin Invest, 35, 305-314. (Pubitemid 40675604)
27. Song S, Zhang Y, Ma K, Jackson-Hayes L, Lavrentyev EN, Cook GA, Elam MB, Park EA. (2004). Peroxisomal proliferator activated receptor gamma coactivator (PGC-1alpha) stimulates carnitine palmitoyltransferase I (CPT-Ialpha) through the first intron. Biochim Biophys Acta, 1679, 164-173. (Pubitemid 39024605)
28. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. (2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, 127, 397-408. (Pubitemid 44572377)
29. Sun Y, Jiang J, Zhang Z, Yu P, Wang L, Xu C, Liu W, Wang Y. (2008). Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Bioorg Med Chem, 16, 8868-8874.
30. Sutter MC, Wang YX. (1993). Recent cardiovascular drugs from Chinese medicinal plants. Cardiovasc Res, 27, 1891-1901. (Pubitemid 23357326)
31. Victor VM, Rocha M, Solá E, Bañuls C, Garcia-Malpartida K, Hernández-Mijares A. (2009). Oxidative stress, endothelial dysfunction and atherosclerosis. Curr Pharm Des, 15, 2988-3002.
32. Wong KL, Chan P, Huang WC, Yang TL, Liu IM, Lai TY, Tsai CC, Cheng JT. (2003). Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells. Clin Exp Pharmacol Physiol, 30, 793-798. (Pubitemid 37330528)
33. Woo KS, Chook P, Raitakari OT, McQuillan B, Feng JZ, Celermajer DS. (1999). Westernization of Chinese adults and increased subclinical atherosclerosis. Arterioscler Thromb Vasc Biol, 19, 2487-2493. (Pubitemid 29477851)
34. Wu GX, Wu JC, Ma HT, Ruan CG. (1992). Inhibitory effects of tetramethylpyrazine on platelets during cardiopulmonary bypass and arterial thrombus formation in dogs. Zhongguo Yao Li Xue Bao, 13, 330-333.
35. Zhang ZH, Yu SZ, Wang ZT, Zhao BL, Hou JW, Yang FJ, Xin WJ. (1994). Scavenging effects of tetramethylpyrazine on active oxygen free radicals. Zhongguo Yao Li Xue Bao, 15, 229-231.