Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: A Brazilian sample study and literature review

Epilepsy and Behavior

Volumn 21, Issue 3, 2011, Pages 228-232

  Koneski, Julio A S ^a   Casella, Erasmo B ^b   Agertt, Fábio ^a   Ferreira, Maria Gabriela ^a  

^a UNIVERSITY OF JOINVILLE REGION   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Attention deficit hyperactivity disorder; Attention deficit hyperactivity disorder and comorbidity; Behavior; Epilepsy; Methylphenidate

Indexed keywords

CARBAMAZEPINE; CLOBAZAM; LAMOTRIGINE; METHYLPHENIDATE; OXCARBAZEPINE; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BRAZIL; CLINICAL ARTICLE; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG EFFICACY; DRUG SAFETY; EPILEPSY; FEMALE; HUMAN; MALE;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAZIL; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DRUG EVALUATION; ELECTROENCEPHALOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; METHYLPHENIDATE; PSYCHIATRIC STATUS RATING SCALES; SEIZURES; TIME FACTORS; TREATMENT OUTCOME;

EID: 79959610379     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.02.029     Document Type: Article

References (76)

1. Tan M., Appleton R. Attention deficit and hyperactivity disorder, methylphenidate, and epilepsy. Arch Dis Child 2005, 90:57-59.
2. Dunn D.W., Austin J.K., Harezlak J., Ambrosius W.T. ADHD and epilepsy in childhood. Dev Med Child Neurol 2003, 45:50-54.
3. Kadesjo B., Gillberg C. The comorbidity of ADHD in the general population of Swedish school-age children. J Child Psychol Psychiatry 2001, 42:487-492.
4. Turky A., Beavis J.M., Thapar A.K., Kerr M.P. Psychopathology in children and adolescents with epilepsy: an investigation of predictive variables. Epilepsy Behav 2008, 12:136-144.
5. Davies S., Heyman I., Goodman R. A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol 2003, 45:292-295.
6. Pellock J.M. Understanding co-morbidities affecting children with epilepsy. Neurology 2004, 62(5, Suppl. 2):S17-S23.
7. Dunn D.W., Austin J.K., Perkins S.M. Prevalence of psychopathology in childhood epilepsy: categorical and dimensional measures. Dev Med Child Neurol 2009, 51:364-372.
8. Zaccara G. Neurological comorbidity and epilepsy: implications for treatment. Acta Neurol Scand 2009, 120:1-15.
9. Wiegartz P., Seidenberg M., Woodard A., Gidal B., Hermann B. Co-morbid psychiatric disorder in chronic epilepsy: recognition and etiology of depression. Neurology 1999, 53(5, Suppl. 2):S3-S8.
10. Dunn D.W., Austin J.K. Differential diagnosis and treatment of psychiatric disorders in children and adolescents with epilepsy. Epilepsy Behav 2004, 5(Suppl. 3):S10-S17.
11. Davis S.M., Katusic S.K., Barbaresi W.J., et al. Epilepsy in children with attention-deficit/hyperactivity disorder. Pediatr Neurol 2010, 42:325-330.
12. Nissen S.E. ADHD drugs and cardiovascular risk. N Engl J Med 2006, 354:1445-1448.
13. Hanssen-Bauer K., Heyerdahl S., Eriksson A.S. Mental health problems in children and adolescents referred to a national epilepsy center. Epilepsy Behav 2007, 10:255-262.
14. Sanchez-Carpintero R., Neville B.G. Attentional ability in children with epilepsy. Epilepsia 2003, 44:1340-1349.
15. Hermann B., Jones J., Dabbs K., et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy. Brain 2007, 130(Pt. 12):3135-3148.
16. Hermann B.P., Jones J., Sheth R., Seidenberg M. Cognitive and magnetic resonance volumetric abnormalities in new-onset pediatric epilepsy. Semin Pediatr Neurol 2007, 14:173-180.
17. Schubert R. Attention deficit disorder and epilepsy. Pediatr Neurol 2005, 32:1-10.
18. Parisi P., Moavero R., Verrotti A., Curatolo P. Attention deficit hyperactivity disorder in children with epilepsy. Brain Dev 2010, 32:10-16.
19. Aldenkamp A.P., Arzimanoglou A., Reijs R., Van Mil S. Optimizing therapy of seizures in children and adolescents with ADHD. Neurology 2006, 67(12, Suppl. 4):S49-S51.
20. Dunn D.W., Kronenberger W.G. Childhood epilepsy, attention problems, and ADHD: review and practical considerations. Semin Pediatr Neurol 2005, 12:222-228.
21. Hesdorffer D.C., Ludvigsson P., Olafsson E., Gudmundsson G., Kjartansson O., Hauser W.A. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry 2004, 61:731-736.
22. Palmini A. Transtorno de Hiperatividade/Déficit de Atenção, Descargas Epileptiformes ao EEG, crises epilépticas, e epilepsia: abordagem prática de intrigantes associações. J Epilepsy Clin Neurophysiol 2004, 10:53-58.
23. Kaufmann R., Goldberg-Stern H., Shuper A. Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. J Child Neurol 2009, 24:727-733.
24. Bechtel N., Kobel M., Penner I.K., et al. Decreased fractional anisotropy in the middle cerebellar peduncle in children with epilepsy and/or attention deficit/hyperactivity disorder: a preliminary study. Epilepsy Behav 2009, 15:294-298.
25. Ben-Ari Y., Holmes G.L. Effects of seizures on developmental processes in the immature brain. Lancet Neurol 2006, 5:1055-1063.
26. Sherman E.M., Slick D.J., Connolly M.B., Eyrl K.L. ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia 2007, 48:1083-1091.
27. Van der Oord S., Prins P.J., Oosterlaan J., Emmelkamp P.M. Efficacy of methylphenidate, psychosocial treatments and their combination in school-aged children with ADHD: a meta-analysis. Clin Psychol Rev 2008, 28:783-800.
28. Fabiano G.A., Pelham W.E., Coles E.K., Gnagy E.M., Chronis-Tuscano A., O'Connor B.C. A meta-analysis of behavioral treatments for attention-deficit/hyperactivity disorder. Clin Psychol Rev 2009, 29:129-140.
29. Faraone S.V., Spencer T., Aleardi M., Pagano C., Biederman J. Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorder. J Clin Psychopharmacol 2004, 24:24-29.
30. Teicher M.H., Polcari A., Foley M., et al. Methylphenidate blood levels and therapeutic response in children with attention-deficit hyperactivity disorder: I. Effects of different dosing regimens. J Child Adolesc Psychopharmacol 2006, 16:416-431.
31. Van der Feltz-Cornelis C.M., Aldenkamp A.P. Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial. Epilepsy Behav 2006, 8:659-662.
32. Baptista-Neto L., Dodds A., Rao S., Whitney J., Torres A., Gonzalez-Heydrich J. An expert opinion on methylphenidate treatment for attention deficit hyperactivity disorder in pediatric patients with epilepsy. Expert Opin Investig Drugs 2008, 17:77-84.
33. Torres A.R., Whitney J., Gonzalez-Heydrich J. Attention-deficit/hyperactivity disorder in pediatric patients with epilepsy: review of pharmacological treatment. Epilepsy Behav 2008, 12:217-233.
34. Gross-Tsur V., Manor O., van der Meere J., Joseph A., Shalev R.S. Epilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective?. J Pediatr 1997, 130:670-674.
35. Pisani F., Oteri G., Costa C., Di Raimondo G., Di Perri R. Effects of psychotropic drugs on seizure threshold. Drug Saf 2002, 25:91-110.
36. Hemmer S.A., Pasternak J.F., Zecker S.G., Trommer B.L. Stimulant therapy and seizure risk in children with ADHD. Pediatr Neurol 2001, 24:99-102.
37. Gonzalez-Heydrich J., Weiss M., Connolly M., et al. Pharmacological management of a youth with ADHD and a seizure disorder. J Am Acad Child Adolesc Psychiatry 2006, 45:1527-1532.
38. Kanner A.M. The use of psychotropic drugs in epilepsy: what every neurologist should know. Semin Neurol 2008, 28:379-388.
39. Gonzalez-Heydrich J., Whitney J., Waber D., et al. Adaptive phase I study of OROS methylphenidate treatment of attention deficit hyperactivity disorder with epilepsy. Epilepsy Behav 2010, 18:229-237.
40. Patsalos P.N., Berry D.J., Bourgeois B.F., et al. Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the Subcommission on Therapeutic Drug Monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008, 49:1239-1276.
41. Mulas F., Tellez de Meneses M., Hernandez-Muela S., Mattos L., Pitarch I. Trastorno por deficit de aténcion e hiperactividad y epilepsia. Rev Neurol 2004, 39:192-195.
42. McBride M.C., Wang D.D., Torres C.F. Methylphenidate in therapeutic doses does not lower seizure threshold. Ann Neurol 1986, 20:428.
43. Feldman H., Crumrine P., Handen B.L., Alvin R., Teodori J. Methylphenidate in children with seizures and attention-deficit disorder. Am J Dis Child 1989, 143:1081-1086.
44. Wroblewski B.A., Leary J.M., Phelan A.M., Whyte J., Manning K. Methylphenidate and seizure frequency in brain injured patients with seizure disorders. J Clin Psychiatry 1992, 53:86-89.
45. Finck S., Metz-Lutz M.N., Becache E., et al. Attention-deficit hyperactivity disorder in epileptic children: a new indication for methylphenidate?. Ann Neurol 1995, 38:520.
46. Semrud-Clikeman M., Wical B. Components of attention in children with complex partial seizures with and without ADHD. Epilepsia 1999, 40:211-215.
47. Moore J.L., McAuley J.W., Long L., Bornstein R. An evaluation of the effects of methylphenidate on outcomes in adult epilepsy patients. Epilepsy Behav 2002, 3:92-95.
48. Gucuyener K., Erdemoglu A.K., Senol S., Serdaroglu A., Soysal S., Kockar A.I. Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. J Child Neurol 2003, 18:109-112.
49. Gonzalez-Heydrich J., Whitney J., Hsin O., et al. Efficacy of OROS®MPH for treatment of ADHD plus epilepsy. Paper presented at the American Academy of Child and Adolescent Psychiatry Meeting; San Diego 2006.
50. Gonzalez-Heydrich J., Hsin O., Hickory M., et al. Comparisons of response to stimulant preparation in pediatric epilepsy. Paper presented at the American Academy of Child and Adolescent Psychiatry Meeting; Washington, DC October 2004.
51. Koneski J.A., Casella E.B. Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment. Arq Neuropsiquiatr 2010, 68:107-114.
52. Diagnostic and statistical manual of mental disorders 1994, American Psychiatric Assoc., Washington, DC. 4th ed. (DSM-IV).
53. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981, 22:489-501.
54. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989, 30:389-399.
55. Engel J. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001, 42:796-803.
56. Bordin I.A., Mari J.J., Caeiro M.F. Validação da versão brasileira do "Child Behavior Checklist" (CBCL) (Inventário de comportamentos da infância e adolescência): dados preliminares. Rev ABP-APAL 1995, 17:55-66.
57. Duarte C.S., Bordin I.A. Instrumentos de avaliação. Rev Bras Psiquiatr 2000, 22(Suppl. II):55-58.
58. Lampert T.L., Polanczyk G., Tramontina S., Mardini V., Rohde L.A. Diagnostic performance of the CBCL-Attention Problem Scale as a screening measure in a sample of Brazilian children with ADHD. J Attention Disord 2004, 8:63-71.
59. Weschler D. WISC-III: Escala de Inteligência de Weschler para Crianças. Adaptação e Padronização Brasileira 2002, Casa do Psicólogo, São Paulo.
60. Greenhill L.L., Pliszka S., Dulcan M.K., et al. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 2002, 41(2, Suppl.):26S-49S.
61. Greenhill L.L., Pliszka S., Dulcan M.K., et al. Summary of the practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 2001, 40:1352-1355.
62. Mattos P., Serra-Pinheiro M.A., Rohde L.A., Pinto D. Apresentação de uma versão em português para o uso no Brasil do instrumento MTA-SNAP-IV de avaliação de sintomas de TDAH e sintomas de transtorno desafiador e de oposição. Rev Psiquiatr RS set/dez 2006, 28:290-297.
63. Correia Filho A.G., Bodanese R., Silva T.L., Alvares J.P., Aman M., Rohde L.A. Comparison of risperidone and methylphenidate for reducing ADHD symptoms in children and adolescents with moderate mental retardation. J Am Acad Child Adolesc Psychiatry 2005, 44:748-755.
64. Weber P., Lutschg J. Methylphenidate treatment. Pediatr Neurol 2002, 26:261-266.
65. Handen B.L., McAuliffe S., Janosky J., Feldman H., Breaux A.M. A playroom observation procedure to assess children with mental retardation and ADHD. J Abnorm Child Psychol 1998, 26:269-277.
66. Antshel K.M., Phillips M.H., Gordon M., Barkley R., Faraone S.V. Is ADHD a valid disorder in children with intellectual delays?. Clin Psychol Rev 2006, 26:555-572.
67. Rohde L.A., Biederman J., Busnello E.A., et al. ADHD in a school sample of Brazilian adolescents: a study of prevalence, comorbid conditions, and impairments. J Am Acad Child Adolesc Psychiatry 1999, 38:716-722.
68. Faraone S.V., Sergeant J., Gillberg C., Biederman J. The worldwide prevalence of ADHD: is it an American condition?. World Psychiatry 2003, 2:104-113.
69. Biederman J., Faraone S.V. Attention-deficit hyperactivity disorder. Lancet 2005, 366:237-248.
70. Lahey B.B., Pelham W.E., Loney J., Lee S.S., Willcutt E. Instability of the DSM-IV subtypes of ADHD from preschool through elementary school. Arch Gen Psychiatry 2005, 62:896-902.
71. Souza I., Serra M.A., Mattos P., Franco V.A. Comorbidades em crianças e adolescentes com transtorno do déficit de atenção: resultados preliminares. Arq Neuropsiquiatr 2001, 59:401-406.
72. Thome-Souza S., Kuczynski E., Assumpcao F., et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy?. Epilepsy Behav 2004, 5:988-994.
73. Jones J.E., Watson R., Sheth R., et al. Psychiatric comorbidity in children with new onset epilepsy. Dev Med Child Neurol 2007, 49:493-497.
74. Gonzalez-Heydrich J., Dodds A., Whitney J., et al. Psychiatric disorders and behavioral characteristics of pediatric patients with both epilepsy and attention-deficit hyperactivity disorder. Epilepsy Behav 2007, 10:384-388.
75. The MTA Cooperative Group A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder: Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry 1999, 56:1073-1086.
76. McAfee A.T., Chilcott K.E., Johannes C.B., Hornbuckle K., Hauser W.A., Walker A.M. The incidence of first provoked and unprovoked seizure in pediatric patients with and without psychiatric diagnoses. Epilepsia 2007, 48:1075-1082.