Attention-deficit disorders and epilepsy in childhood: Incidence, causative relations and treatment possibilities

Journal of Child Neurology

Volumn 24, Issue 6, 2009, Pages 727-733

  Kaufmann, Rami ^a,c   Goldberg Stern, Hadassa ^b,c   Shuper, Avinoam ^a,c  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b Epilepsy Center   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Attention deficit hyperactivity disorder (ADHD); Epilepsy; Methylphenidate

Indexed keywords

ANTICONVULSIVE AGENT; ATOMOXETINE; ETHOSUXIMIDE; METHYLPHENIDATE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PRIMIDONE;

ATTENTION DEFICIT DISORDER; CAUSAL ATTRIBUTION; CHILD; CLINICAL TRIAL; COMORBIDITY; DISEASE ASSOCIATION; DRUG DOSE TITRATION; ECG ABNORMALITY; ELECTROCARDIOGRAM; EPILEPSY; EPILEPTIC DISCHARGE; GENETIC SUSCEPTIBILITY; HUMAN; INCIDENCE; NEUROLOGIC DISEASE; NORADRENERGIC SYSTEM; PREVALENCE; PRIORITY JOURNAL; PSYCHOSOCIAL DISORDER; REVIEW; RISK FACTOR; SEIZURE; SEIZURE THRESHOLD; SIDE EFFECT; SLEEP DEPRIVATION; UNSPECIFIED SIDE EFFECT;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; CHILD; COMORBIDITY; ELECTROENCEPHALOGRAPHY; EPILEPSY; HUMANS; INCIDENCE; METHYLPHENIDATE; PREVALENCE;

EID: 66849104119     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883073808330165     Document Type: Review

References (48)

1. Rappley MD Attention deficit hyperactivity disorder. N Engl J Med. 2005;352:165-173.
2. Polanczyk G., de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: A systemic review and metaregression analysis. Am J Psychiatry. 2007;164:942-948.
3. Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1263-1272.
4. Castellanos FX, Lee PP, Sharp W., et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA. 2002;288:1740-1748.
5. Bush G., Valera EM, Seidman LJ Functional neuroimaging of attention-deficit/hyperactivity disorder: A review and suggested future directions. Biol Psychiatry. 2005;57:1273-1284.
6. Alexander GE, DeLong MR, Strick PL Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357-381.
7. Zametkin AJ, Rapoport JL Noradrenergic hypothesis of attention deficit disorder with hyperactivity: A critical review. In: Meltzer HY, ed. Psychopharmacology: The Third Generation of Progress. New York: Raven Press; 1987:837-842.
8. Pliszka SR Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: An overview. J Clin Psychiatry. 1998;59:50-58.
9. Berquin PC, Giedd JN, Jacobsen LK, et al. Cerebellum in attention-deficit hyperactivity disorder: A morphometric MRI study. Neurology. 1998;50:1087-1093.
10. Bauman RJ Classification and population studies of epilepsy. In: Anderson VA, ed. Genetic Basis of the Epilepsies. New York: Raven Press; 1982:11-20.
11. Goodbridge DMG, Shorvon SD Epileptic seizures in a population of 6000. I. Demography, diagnosis and classification and role of the hospital services. Br Med J. 1983;287:641-645.
12. Gross-Tsur V., Manor O., van der Meere J., et al. Epilepsy and attention deficit hyperactivity disorder: Is methylphenidate safe and effective? J Pediatr. 1997;130:670-674.
13. Dunn DW, Austin JK, Harezlak J., Ambrosius WT ADHD and epilepsy in childhood. Dev Med Child Neurol. 2003;45:50-54.
14. Richer LP, Shevell MI, Rosenblatt BR Epileptiform abnormalities in children with attention-deficit-hyperactivity disorder. Pediatr Neurol. 2002;26:125-129.
15. Hughes JR, Deleo AJ, Melyn MA The electroencephalogram in attention deficit-hyperactivity disorder: Emphasis on epileptiform discharges. Epilepsy Behav. 2000;1:271-277.
16. Holtmann M., Becker K., Kentner-Figura B., Schmidt MH Increased frequency of rolandic spikes in ADHD children. Epilepsia. 2004;44:1241-1244.
17. Becker K., Sinzig JK, Holtmann M. Attention deficits and subclinical epileptiform discharges: Are EEG diagnostics in ADHD, optional or essential? Dev Med Child Neurol. 2004;46:431-432.
18. Tan M., Appleton R. Attention deficit and hyperactivity disorder, methylphenidate and epilepsy. Arch Dis Child. 2005;90:57-59.
19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4 th ed. Washington, DC: APA Press; 1994.
20. Weinberg WA, Harper CR, Schraufnagel CD, Brumback RA Attention deficit and hyperactivity disorder: A disease or a symptom complex? J Pediatr. 1997;130:665-669.
21. Hesdorffer DC, Ludvigsson P., Olafsson E., et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry. 2004;61:731-736.
22. Weinshenker D., Szot P. The role of catecholamines in seizure susceptibility. New results using genetically engineered mice. Pharmacol Ther. 2002;94:213-233.
23. Dailey JW, Mishra PK, Ko KH, et al. Noradrenergic abnormalities in the central nervous system of seizure-naïve genetically epilepsy-prone rats. Epilepsia.1991;32: 168-173.
24. Anderson GM, Dover MA, Yang BP, et al. Adrenomedullary function during cognitive testing in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2000;39:635-643.
25. Hermann B., Jones J., Dabbs K., et al. The frequency, complication and aetiology of ADHD in new onset paediatric epilepsy. Brain. 2007;12:3135-3148.
26. Austin JK, Harezlak J., Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics. 2001;107:115-122.
27. Marston D., Besag F., Binnie CD, Fowler M. Effects of transitory cognitive impairment on psychosocial functioning of children with epilepsy: A therapeutic trial. Dev Med Child Neurol. 1993;35:574-581.
28. Murphy P., Burnham WM The ketogenic diet causes a reversible decrease in activity level in Long-Evans rats. Exp Neurol. 2006;201:84-89.
29. Lerman P., Lerman-Sagie T., Kivity S. Effect of early corticosteroid therapy for Landau Kleffner syndrome. Dev Med Child Neurol. 1991;33:257-260.
30. Williams J., Bates S., Griebel ML, et al. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes? Epilepsia. 1998;39:1064-1069.
31. Aldenkamp AP, Alpherts WCJ, Blennow G., et al. Withdrawal of antiepileptic medication in children. Effects on cognitive function. The Multicenter Holmfrid Study. Neurology. 1993;43:41-50.
32. Bourgeois BFD Antiepileptic drugs, learning and behavior in childhood epilepsy. Epilepsia. 1998;39:913-921.
33. Martin R., Kuzniecky R., Ho S., et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology. 2000;52:321-327.
34. Barkley RA Attention Deficit Hyperactivity Disorder. 2 nd ed. New York: Guilford Press; 1998:175-176.
35. Oostrom KJ, Schouten A., Kruitwagen CLJ, et al. Attention deficits are not characteristic of schoolchildren with newly diagnosed idiopathic or cryptogenic epilepsy. Epilepsia. 2002;43:301-310.
36. Szatmari P., Offord DR, Boyle MH The Ontario child health study: prevalence of attention deficit disorder with hyperactivity. J Child Psychol Psychiatry. 1989;30:219-230.
37. Castellanos FX Neuroimaging studies of ADHD. In: Solanto MV, Arnsten AFT, Castellanos FX, eds. Stimulant Drugs and ADHD. New York: Oxford University Press; 2001:243-258.
38. Stein MA, Blondis TA Methylphenidate dosing: Twice daily versus three times daily. Pediatrics. 1996;98:748-756.
39. Feldman H., Crumrine P., Handen BL, Alvin R., Teodori J. Methylphenidate in children with seizures and attention deficit disorder. Am J Dis Child. 1989;143:1081-1086.
40. Gucuyener K., Erdemoglu K., Senol S., et al. Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. J Child Neurol. 2003;18:109-112.
41. Clarke AR, Barry RJ, Bond D., et al. Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology. 2002;164:277-278.
42. Hemmer SA, Pasternak JF, Zecker SG, Trommer BL Stimulant therapy and seizure risk in children with ADHD. Pediatr Neurol. 2001;24:99-102.
43. Wroblewski BA, Leary JM, Phelan AM, et al. Methylphenidate and seizure frequency in brain-injured patients with seizure disorders. J Clin Psychiatry. 1992;53:86-89.
44. McBride MC, Wang DD, Torres CF Methylphenidate in therapeutic doses does not lower seizure threshold. Ann Neurol. 1986;20:428.
45. Gonzales-Heydrich J., Hsin O., Hickory M., et al. Comparisons of response to stimulant preparations in pediatric epilepsy. Meeting of the American Academy of Child and Adolescent Psychiatry, 2004, Washington, DC.
46. Baptista-Neto L., Dodds A., Rao S., et al. An expert opinion on methylphenidate treatment for attention deficit hyperactivity disorder in pediatric patients with epilepsy. Expert Opin Investig Drugs. 2008;17:77-84.
47. Torres AR, Whitney J., Gonzalez-Heydrich J. Attention-deficit/ hyperactivity disorder in pediatric patients with epilepsy: Review of pharmacological treatment. Epilepsy Behav. 2008;12:217-233.
48. Wernicke JF, Holdrige KC, Jin L., et al. Seizure risk in patients with attention deficit hyperactivity disorder treated with atomoxetine. Dev Med Child Neurol. 2007;49:498-502.