Appearance of nuclear-sorted caspase-12 fragments in cerebral cortical and hippocampal neurons in rats damaged by autologous blood clot embolic brain infarctions

Cellular and Molecular Neurobiology

Volumn 31, Issue 5, 2011, Pages 795-802

  Shimoke, Koji ^a   Matsuki, Yoshinori ^b,c   Fukunaga, Kenji ^a   Matsumura, Yoshinobu ^a   Fujita, Eriko ^d   Sugihara, Kensuke ^a   Nobuhara, Masamichi ^a   Maruoka, Hiroki ^a,e   Ikeuchi, Toshihiko ^a   Kudo, Motoshige ^b  

^a KANSAI UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c MITSUI MEMORIAL HOSPITAL   (Japan)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^e KURABO INDUSTRIES LTD   (Japan)

Author keywords

Apoptosis; Caspase 12; Cerebral infarction; Endoplasmic reticulum stress; Nucleus; Translocation

Indexed keywords

CASPASE 12; GLUCOSE REGULATED PROTEIN 78;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT; BRAIN CORTEX; BRAIN EMBOLISM; BRAIN INFARCTION; BRAIN NERVE CELL; CELL NUCLEUS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN TRANSPORT; RAT; UPREGULATION;

ANIMALS; APOPTOSIS; BRAIN INFARCTION; CASPASE 12; CELL NUCLEUS; CEREBRAL CORTEX; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; IN SITU NICK-END LABELING; INTRACRANIAL EMBOLISM; MALE; MODELS, BIOLOGICAL; NEURONS; PEPTIDE FRAGMENTS; PROTEIN TRANSPORT; RATS; RATS, WISTAR; STAINING AND LABELING; STRESS, PHYSIOLOGICAL; THROMBOSIS;

RATTUS;

EID: 79959595004     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9687-0     Document Type: Article

References (33)

1. Back SH, Schroder M, Lee K, Zhang K, Kaufman RJ (2005) ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods 35:395-416 (Pubitemid 40445374)
2. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326-332
3. DeGracia DJ, Montie HL (2004) Cerebral ischemia and the unfolded protein response. J Neurochem 91:1-8 (Pubitemid 39314931)
4. Di Sano F, Ferraro E, Tufi R, Achsel T, Piacentini M, Cecconi F (2006) Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism. J Biol Chem 281:2693-2700 (Pubitemid 43845732)
5. Feng Y, Kudo M, Shimoke K, Ikeuchi T, Ebihara Y, Takasaki M (2002) Suppression of angiogenesis causes a significant delay of repair process in rat thromboembolic cerebral infarction. J Tokyo Med Univ 60:489-500 (Pubitemid 36504170)
6. Fujita E, Kouroku Y, Jimbo A, Isoai A, Maruyama K, Momoi T (2002) Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells. Cell Death Differ 9:1108-1114
7. Imaizumi K, Miyoshi K, Katayama T, Yoneda T, Taniguchi M, Kudo T, Tohyama M (2001) The unfolded protein response and Alzheimer's disease. Biochim Biophys Acta 1536:85-96 (Pubitemid 32530807)
8. Ito D, Tanaka K, Suzuki S, Dembo T, Kosakai A, Fukuuchi Y (2001) Up-regulation of the Ire1-mediated signaling molecule, Bip, in ischemic rat brain. Neuroreport 12:4023-4028 (Pubitemid 33152446)
9. Kalai M, Lamkanfi M, Denecker G, Boogmans M, Lippens S, Meeus A, Declercq W, Vandenabeele P (2003) Regulation of the expression and processing of caspase-12. J Cell Biol 162:457-467 (Pubitemid 36988554)
10. Kishi S, Shimoke K, Nakatani Y, Shimada T, Okumura N, Nagai K, Shin-Ya K, Ikeuchi T (2010) Nerve growth factor attenuates 2-deoxy-D-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neurosci Res 66:14-21
11. Kudo M, Aoyama A, Ichimori S, Fukunaga N (1982) An animal model of cerebral infarction. Homologous blood clot emboli in rats. Stroke 13:505-508
12. Lee AS (2005) The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 35:373-381
13. Morimoto N, Oida Y, Shimazawa M, Miura M, Kudo T, Imaizumi K, Hara H (2007) Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice. Neuroscience 147:957-967 (Pubitemid 47102538)
14. Murakami Y, Aizu-Yokota E, Sonoda Y, Ohta S, Kasahara T (2007) Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2. J Biochem 141:401-410 (Pubitemid 46770392)
15. Nakagawa T, Yuan J (2000) Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150:887-894 (Pubitemid 30663424)
16. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103 (Pubitemid 30038529)
17. 2+ depletion induces endothelial cell apoptosis independently of caspase-12. Cardiovasc Res 69:908-915
18. Obeng EA, Boise LH (2005) Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem 280:29578-29587 (Pubitemid 41177033)
19. Paschen W, Aufenberg C, Hotop S, Mengesdorf T (2003) Transient cerebral ischemia activates processing of xbp1 messenger RNA indicative of endoplasmic reticulum stress. J Cereb Blood Flow Metab 23:449-461 (Pubitemid 36403027)
20. Pennington R, Gatenbee C, Kennedy B, Harpending H, Cochran G (2009) Group differences in proneness to inflammation. Infect Genet Evol 9:1371-1380
21. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE (2002) Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett 514:122-128 (Pubitemid 34273925)
22. Rojas-Rivera D, Caballero B, Zamorano S, Lisbona F, Hetz C (2010) Alternative functions of the BCL-2 protein family at the endoplasmic reticulum. Adv Exp Med Biol 687:33-47
23. Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6:379-385 (Pubitemid 40561632)
24. Schroder M, Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569:29-63 (Pubitemid 39643256)
25. Shen X, Zhang K, Kaufman RJ (2004) The unfolded protein response-a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat 28:79-92 (Pubitemid 39195253)
26. Shibata M, Hattori H, Sasaki T, Gotoh J, Hamada J, Fukuuchi Y (2003) Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice. Neuroscience 118:491-499 (Pubitemid 36423263)
27. Shimoke K, Amano H, Kishi S, Uchida H, Kudo M, Ikeuchi T (2004a) Nerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via suppression of caspase-12 activity. J Biochem 135:439-446 (Pubitemid 38506770)
28. Shimoke K, Utsumi T, Kishi S, Nishimura M, Sasaya H, Kudo M, Ikeuchi T (2004b) Prevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neurons. Brain Res 1028:105-111 (Pubitemid 39424183)
29. Shimoke K, Kishi S, Utsumi T, Shimamura Y, Sasaya H, Oikawa T, Uesato S, Ikeuchi T (2005) NGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells. Neurosci Lett 389:124-128 (Pubitemid 41267211)
30. Urano F, Bertolotti A, Ron D (2000) IRE1 and efferent signaling from the endoplasmic reticulum. J Cell Sci 113(Pt 21):3697-3702
31. Wootz H, Hansson I, Korhonen L, Napankangas U, Lindholm D (2004) Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem Biophys Res Commun 322:281-286 (Pubitemid 39093867)
32. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107:881-891 (Pubitemid 34084979)
33. Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162:59-69 (Pubitemid 36859535)