Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma x glioma hybrid NG108-15 cells

Cellular and Molecular Neurobiology

Volumn 31, Issue 5, 2011, Pages 663-668

  Tsuji, Takahiro ^a   Higashida, Chiharu ^a,b   Yoshida, Yasumasa ^d   Islam, Mohammad Saharul ^a   Dohmoto, Mitsuko ^d   Koizumi, Keita ^a,c   Higashida, Haruhiro ^a,b,c  

^a Graduate School of Medical Science   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Molecular Research Center for Children's Mental Development   (Japan)

^d KANAZAWA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Differentiation; Guanine nucleotide exchange factors; Neuron; NG108 15; RNA interference screening

Indexed keywords

ACETYLCHOLINESTERASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; PROTEIN ECT2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; EMBRYO; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE;

ANIMALS; CELL LINE, TUMOR; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYBRID CELLS; MALE; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; NEURITES; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA; RATTUS;

EID: 79959578378     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9668-3     Document Type: Article

References (30)

1. Amano T, Richelson E, Nirenberg M (1972) Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiationcell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites). Proc Natl Acad Sci USA 69: 258-263
2. Durand B, Raff M (2000) A cell-intrinsic timer that operates during oligodendrocyte development. Bioessays 22:64-71 (Pubitemid 30057135)
3. Gotz M, Huttner WB (2005) The cell biology of neurogenesis. Nat Rev Mol Cell Biol 6(10):777-788 (Pubitemid 41726116)
4. Govek EE, Newey SE, Van Aelst L (2005) The role of the Rho GTPases in neuronal development. Genes Dev 19:1-49 (Pubitemid 40095815)
5. Hamprecht B (1977) Structural, electrophysiological, biochemical, and pharmacological properties of neuroblastoma-glioma cell hybrids in cell culture. Int Rev Cytol 49:99-170
6. Higashida H, Kato T, Kano-Tanaka K, Okuya M, Miyake A, Tanaka T (1981) Proliferation and synapse formation of neuroblastoma glioma hybrid cells: effects of glia maturation factor. Brain Res 214:287-299 (Pubitemid 11114093)
7. Higashida H, Streaty RA, Klee W, Nirenberg M (1986) Bradykininactivated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells. Proc Natl Acad Sci USA 83:942-946 (Pubitemid 16086391)
8. Islam MS, Tsuji T, Higashida C, Takahashi M, Higashida H, Koizumi K (2010) Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary. J Neuroendocrinol 22:477-482
9. Ivanov AI, Rovescalli AC, Pozzi P, Yoo S, Mozer B, Li HP, Yu SH, Higashida H, Guo V, Spencer M, Nirenberg M (2004) Genes required for Drosophila nervous system development identified by RNA interference. Proc Natl Acad Sci USA 101:16216-16221 (Pubitemid 39552825)
10. Kishi K, Sasaki T, Kuroda S, Itoh T, Takai Y (1993) Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J Cell Biol 120:1187-1195
11. Koizumi K, Higashida H, Yoo S, Islam MS, Ivanov AI, Guo V, Pozzi P, Yu SH, Rovescalli AC, Tang D, Nirenberg M (2007) RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci USA 104:5626-5631 (Pubitemid 47175731)
12. Kraut R, Menon K, Zinn K (2001) A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. Curr Biol 11:417-430 (Pubitemid 32241519)
13. Mabuchi I, Hamaguchi Y, Fujimoto H, Morii N, Mishima M, Narumiya S (1993) A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote 1:325-331 (Pubitemid 2018351)
14. MacDermot J, Higashida H, Wilson SP, Matsuzawa H, Minna J, Nirenberg M (1979) Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids. Proc Natl Acad Sci USA 76:1135-1139 (Pubitemid 9135168)
15. McGee R, Simpson P, Christian C, Mata M, Nelson P, Nirenberg M (1978) Regulation of acetylcholine release from neuroblastoma 9 glioma hybrid cells. Proc Natl Acad Sci USA 75:1314-1318 (Pubitemid 8301626)
16. Miki N, Hayashi Y, Higashida H (1981) Characterization of chick gizzard extract that promotes neurite outgrowth in cultured ciliary neurons. J Neurochem 37:627-633 (Pubitemid 11016894)
17. Minna J, Glazer D, Nirenberg M (1972) Genetic dissection of neural properties using somatic cell hybrids. Nat New Biol 235:225-231
18. Nelson P, Christian C, Nirenberg M (1976) Synapse formation between clonal neuroblastoma 9 glioma hybrid cells and striated muscle cells. Proc Natl Acad Sci USA 73:123-127
19. Nirenberg M, Wilson S, Higashida H, Rotter A, Krueger K, Busis N, Ray R, Kenimer JG, Adler M (1983) Modulation of synapse formation by cyclic adenosine monophosphate. Science 222: 794-799 (Pubitemid 14227546)
20. Prokopenko SN, Brumby A, O'Keefe L, Prior L, He Y, Saint R, Bellen HJ (1999) A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev 13:2301-2314 (Pubitemid 29426733)
21. Prokopenko SN, He Y, Lu Y, Bellen HJ (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156:1691-1715 (Pubitemid 32001235)
22. Puro DG, Nirenberg M (1976) On the specificity of synapse formation. Proc Natl Acad Sci USA 73:3544-3548
23. Reiter LT, Seagroves TN, Bowers M, Bier E (2006) Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet 15:2825-2835 (Pubitemid 44400409)
24. Schmidt A, Hall A (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16:1587-1609 (Pubitemid 34743321)
25. Scoumanne A, Chen X (2006) The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition. Cancer Res 66:6271-6279
26. Seeds NW, Gilman AG, Amano T, Nirenberg MW (1970) Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci USA 66:160-167
27. Smallhorn M, Murray MJ, Saint R (2004) The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble. Development 131:2641-2651 (Pubitemid 38877897)
28. Takahashi T, Nowakowski RS, Caviness VS Jr (1995) The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J Neurosci 15:6046-6057
29. Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T (1999) Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J Cell Biol 147:921-928
30. Wilson SH, Schrier BK, Farber JL, Thompson EJ, Rosenberg RN, Blume AJ, Nirenberg MW (1972) Markers for gene expression in cultured cells from the nervous system. J Biol Chem 247: 3159-3169