Does cyclical loading affect the elution of antibiotics from articulating cement knee spacers?

Journal of Bone and Joint Surgery - Series B

Volumn 93 B, Issue 7, 2011, Pages 914-920

  Rogers, B A ^a,c   Middleton, F R ^b,c   Shearwood Porter, N ^c   Kinch, S ^c   Roques, A ^c,d   Bradley, N W ^c,e   Browne, M ^c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b KINGSTON HOSPITAL   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d Kenneth Dibben House   (United Kingdom)

^e ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE CEMENT; TOBRAMYCIN; VANCOMYCIN;

ARTICLE; CONTROLLED STUDY; DRUG RELEASE; DYNAMICS; ELUTION; HUMAN; KNEE FUNCTION; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BONE CEMENTS; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KNEE JOINT; KNEE PROSTHESIS; MATERIALS TESTING; POLYMETHYL METHACRYLATE; PROSTHESIS-RELATED INFECTIONS; REOPERATION; STRESS, MECHANICAL; TOBRAMYCIN; VANCOMYCIN;

EID: 79959573633     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.93B7.25890     Document Type: Article

References (61)

1. Winkelmann W, Schulitz KP, Knothe H, Schoening B. Concentration in bone and haematoma of the aminoglycoside antibiotic tobramycin. Infection 1978;6:277-82 (in German).
2. Mah TF, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001;9:34-9.
3. Gristina AG. Implant failure and the immuno-incompetent fibro-inflammatory zone. Clin Orthop 1994;298:106-18. (Pubitemid 24023599)
4. Barrack RL, Sawhney J, Hsu J, Cofield RH. Cost analysis of revision total hip arthroplasty: a 5-year followup study. Clin Orthop 1999;369:175-8.
5. Crowe JF, Sculco TP, Kahn B. Revision total hip arthroplasty: hospital cost and reimbursement analysis. Clin Orthop 2003;413:175-82. (Pubitemid 38063310)
6. Grogan TJ, Dorey F, Rollins J, Amstutz HC. Deep sepsis following total knee arthroplasty: ten-year experience at the University of California at Los Angeles Medical Center. J Bone Joint Surg [Am] 1986;68-A:226-34.
7. Wilson MG, Kelley K, Thornhill TS. Infection as a complication of total kneereplacement arthroplasty: risk factors and treatment in sixty-seven cases. J Bone Joint Surg [Am] 1990;72-A:878-83. (Pubitemid 20246892)
8. Willis-Owen CA, Konyves A, Martin DK. Factors affecting the incidence of infection in hip and knee replacement: an analysis of 5277 cases. J Bone Joint Surg [Br] 2010;92-B:1128-33.
9. Bengtson S, Blomgren G, Knutson K, Wigren A, Lidgren L. Hematogenous infection after knee arthroplasty. Acta Orthop Scand 1987;58:529-34. (Pubitemid 18034247)
10. Bengtson S, Borgquist L, Lidgren L. Cost analysis of prophylaxis with antibiotics to prevent infected knee arthroplasty. BMJ 1989;299:719-20. (Pubitemid 19235920)
11. Haddad FS, Masri BA, Campbell D, et al. The PROSTALAC functional spacer in two-stage revision for infected knee replacements: prosthesis of antibiotic-loaded acrylic cement. J Bone Joint Surg [Br] 2000;82-B:807-12. (Pubitemid 30624038)
12. Windsor RE, Insall JN, Urs WK, Miller DV, Brause BD. Two-stage reimplantation for the salvage of total knee arthroplasty complicated by infection: further follow-up and refinement of indications. J Bone Joint Surg [Am] 1990;72-A:272-8. (Pubitemid 20123699)
13. Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty 1998;13:331-8. (Pubitemid 28194004)
14. Haddad FS, Bridgens A. Infection following hip replacement: solution options. Orthopedics 2008;31:907-8.
15. Hanssen AD, Spangehl MJ. Practical applications of antibiotic-loaded bone cement for treatment of infected joint replacements. Clin Orthop 2004;427:79-85. (Pubitemid 39362835)
16. Hanssen AD. Prophylactic use of antibiotic bone cement: an emerging standard: in opposition. J Arthroplasty 2004;19(Suppl 1):73-7. (Pubitemid 38746721)
17. Marks KE, Nelson CL, Lautenschlager EP. Antibiotic-impregnated acrylic bone cement. J Bone Joint Surg [Am] 1976;58-A:358-64.
18. Jacobs C, Christensen CP, Berend ME. Static and mobile antibiotic-impregnated cement spacers for the management of prosthetic joint infection. J Am Acad Orthop Surg 2009;17:356-68.
19. Villanueva-Martinez M, Rios-Luna A, Pereiro J, Fahandez-Saddi H, Villamor A. Hand-made articulating spacers in two-stage revision for infected total knee arthroplasty: good outcome in 30 patients. Acta Orthop 2008;79:674-82.
20. Bose WJ, Gearen PF, Randall JC, Petty W. Long-term outcome of 42 knees with chronic infection after total knee arthroplasty. Clin Orthop 1995;319:285-96.
21. Freeman MG, Fehring TK, Odum SM, et al. Functional advantage of articulating versus static spacers in 2-stage revision for total knee arthroplasty infection. J Arthroplasty 2007;22:1116-21.
22. Emerson RH Jr, Muncie M, Tarbox TR, Higgins LL. Comparison of a static with a mobile spacer in total knee infection. Clin Orthop 2002;404:132-8. (Pubitemid 35351062)
23. Evans RP. Successful treatment of total hip and knee infection with articulating antibiotic components: a modified treatment method. Clin Orthop 2004;427:37-46. (Pubitemid 39362828)
24. Hofmann AA, Goldberg T, Tanner AM, Kurtin SM. Treatment of infected total knee arthroplasty using an articulating spacer: 2- to 12-year experience. Clin Orthop 2005;430:125-31. (Pubitemid 40096141)
25. Pitto RP, Spika IA. Antibiotic-loaded bone cement spacers in two-stage management of infected total knee arthroplasty. Int Orthop 2004;28:129-33. (Pubitemid 38878833)
26. Fehring TK, Odum S, Calton TF, Mason JB. The Ranawat Award: articulating versus static spacers in revision total knee arthroplasty for sepsis. Clin Orthop 2000;380:9-16.
27. Takahira N, Itoman M, Higashi K, et al. Treatment outcome of two-stage revision total hip arthroplasty for infected hip arthroplasty using antibiotic-impregnated cement spacer. J Orthop Sci 2003;8:26-31. (Pubitemid 36240902)
28. Seldes RM, Winiarsky R, Jordan LC, et al. Liquid gentamicin in bone cement: a laboratory study of a potentially more cost-effective cement spacer. J Bone Joint Surg [Am] 2005;87-A:268-72. (Pubitemid 40216622)
29. He Y, Trotignon JP, Loty B, Tcharkhtchi A, Verdu J. Effect of antibiotics on the properties of poly(methylmethacrylate)-based bone cement. J Biomed Mater Res 2002;63:800-6. (Pubitemid 35375428)
30. Joseph TN, Chen AL, Di Cesare PE. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg 2003;11:38-47.
31. Stefánsdóttir A, Johansson D, Knutson K, Lidgren L, Robertsson O. Microbiology of the infected knee arthroplasty: report from the Swedish Knee Arthroplasty Register on 426 surgically revised cases. Scand J Infect Dis 2009;41:831-40.
32. Scott CP, Higham PA, Dumbleton JH. Effectiveness of bone cement containing tobramycin: an in vitro susceptibility study of 99 organisms found in infected joint arthroplasty. J Bone Joint Surg [Br] 1999;81-B:440-3.
33. Baleani M, Persson C, Zolezzi C, et al. Biological and biomechanical effects of vancomycin and meropenem in acrylic bone cement. J Arthroplasty 2008;23:1232-8.
34. Hendriks JG, van Horn JR, van der Mei HC, Busscher HJ. Backgrounds of antibiotic-loaded bone cement and prosthesis-related infection. Biomaterials 2004;25:545-56. (Pubitemid 37329707)
35. Schurman DJ, Trindade C, Hirshman HP, et al. Antibiotic-acrylic bone cement composites: studies of gentamicin and Palacos. J Bone Joint Surg [Am] 1978;60-A:978-84.
36. Urabe K, Naruse K, Hattori H, et al. In vitro comparison of elution characteristics of vancomycin from calcium phosphate cement and polymethylmethacrylate. J Orthop Sci 2009;14:784-93.
37. Liu W, Maitland ME. The effect of hamstring muscle compensation for anterior laxity in the ACL-deficient knee during gait. J Biomech 2000;33:871-9. (Pubitemid 30265581)
38. Haleem AA, Berry DJ, Hanssen AD. Mid-term to long-term followup of two-stage reimplantation for infected total knee arthroplasty. Clin Orthop 2004;428:35-9. (Pubitemid 39506148)
39. Virto MR, Frutos P, Torrado S, Frutos G. Gentamicin release from modified acrylic bone cements with lactose and hydroxypropylmethylcellulose. Biomaterials 2003;24:79-87. (Pubitemid 35300206)
40. Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty 1996;11:939-44.
41. van de Belt H, Neut D, Schenk W, et al. Gentamicin release from polymethylmethacrylate bone cements and Staphylococcus aureus biofilm formation. Acta Orthop Scand 2000;71:625-9.
42. van de Belt H, Neut D, Schenk W, et al. Staphylococcus aureus biofilm formation on different gentamicin-loaded polymethylmethacrylate bone cements. Biomaterials 2001;22:1607-11. (Pubitemid 32551910)
43. Picknell B, Mizen L, Sutherland R. Antibacterial activity of antibiotics in acrylic bone cement. J Bone Joint Surg [Br] 1977;59-B:302-7. (Pubitemid 8168943)
44. Rodeheaver GT, Rukstalis D, Bono M, Bellamy W. A new model of bone infection used to evaluate the efficacy of antibiotic-impregnated polymethylmethacrylate cement. Clin Orthop 1983;178:303-11. (Pubitemid 13001175)
45. Hoff SF, Fitzgerald RH Jr, Kelly PJ. The depot administration of penicillin G and gentamicin in acrylic bone cement. J Bone Joint Surg [Am] 1981;63-A:798-804. (Pubitemid 11127665)
46. Wahlig H, Buchholz HW. Experimental and clinical studies on the release of gentamicin from bone cement. Chirurg 1972;43:441-5 (in German).
47. Baker AS, Greenham LW. Release of gentamicin from acrylic bone cement: elution and diffusion studies. J Bone Joint Surg [Am] 1988;70-A:1551-7.
48. Greene N, Holtom PD, Warren CA, et al. In vitro elution of tobramycin and vancomycin polymethylmethacrylate beads and spacers from Simplex and Palacos. Am J Orthop (Belle Mead NJ) 1998;27:201-5.
49. Reimer LG, Mirrett S, Reller LB. Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates. Antimicrob Agents Chemother 1980;17:412-16. (Pubitemid 10094316)
50. Gillespie EL, Kuti JL, Nicolau DP. Pharmacodynamics of antimicrobials: treatment optimisation. Expert Opin Drug Metab Toxicol 2005;1:351-61.
51. Adams K, Couch L, Cierny G, Calhoun J, Mader JT. In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylete beads. Clin Orthop 1992;278:244-52.
52. Lewis G, Janna S, Bhattaram A. Influence of the method of blending an antibiotic powder with an acrylic bone cement powder on physical, mechanical, and thermal properties of the cured cement. Biomaterials 2005;26:4317-25. (Pubitemid 40430860)
53. Guven GS, Uzun O. Principles of good use of antibiotics in hospitals. J Hosp Infect 2003;52:91-6. (Pubitemid 38002064)
54. Rybak MJ, Abate BJ, Kang SL, et al. Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob Agents Chemother 1999;43:1549-55. (Pubitemid 29331226)
55. Chan GL. Alternative dosing strategy for aminoglycosides: impact on efficacy, nephrotoxicity, and ototoxicity. DICP 1989;23:788-94. (Pubitemid 19253971)
56. van de Belt H, Neut D, van Horn JR, et al. .....or not to treat? Nat Med 1999;5:358-9.
57. van de Belt H, Neut D, Uges DR, et al. Surface roughness, porosity and wettability of gentamicin-loaded bone cements and their antibiotic release. Biomaterials 2000;21:1981-7. (Pubitemid 30433826)
58. van de Belt H, Neut D, Schenk W, et al. Infection of orthopedic implants and the use of antibiotic-loaded bone cements: a review. Acta Orthop Scand 2001;72:557-71. (Pubitemid 34031652)
59. Law HT, Fleming RH, Gilmore MF, McCarthy ID, Hughes SP. In vitro measurement and computer modelling of the diffusion of antibiotic in bone cement. J Biomed Eng 1986;8:149-55. (Pubitemid 16142938)
60. Bayston R, Milner RD. The sustained release of antimicrobial drugs from bone cement: an appraisal of laboratory investigations and their significance. J Bone Joint Surg [Br] 1982;64-B:460-4. (Pubitemid 12003820)
61. Unemori M, Matsuya Y, Matsuya S, Akashi A, Akamine A. Water absorption of poly(methylmethacrylate) containing 4-methacryloxyethyl trimellitic anhydride. Biomaterials 2003;24:1381-7. (Pubitemid 36069105)