-
1
-
-
21844462147
-
Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
-
Zaccarelli M, Tozzi V, Lorenzini P, et al. Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients. AIDS 2005; 19:1081-1089. (Pubitemid 40961149)
-
(2005)
AIDS
, vol.19
, Issue.10
, pp. 1081-1089
-
-
Zaccarelli, M.1
Tozzi, V.2
Lorenzini, P.3
Trotta, M.P.4
Forbici, F.5
Visco-Comandini, U.6
Gori, C.7
Narciso, P.8
Perno, C.F.9
Antinori, A.10
-
2
-
-
39549103445
-
Genotypic resistance profile and clinical progression of treatment-experienced HIV type 1-infected patients with virological failure
-
DOI 10.1089/aid.2007.0070
-
Di Giambenedetto S, Colafigli M, Pinnetti C, et al. Genotypic resistance profile and clinical progression of treatment-experienced HIV type 1-infected patients with virological failure. AIDS Res Hum Retroviruses 2008; 24:149-154. (Pubitemid 351282093)
-
(2008)
AIDS Research and Human Retroviruses
, vol.24
, Issue.2
, pp. 149-154
-
-
Di, G.S.1
Colafigli, M.2
Pinnetti, C.3
Bacarelli, A.4
Cingolani, A.5
Tamburrini, E.6
Cauda, R.7
De Luca, A.8
-
3
-
-
34047215574
-
Resistance costs and future drug options of antiretroviral therapies: Analysis of the role of NRTIs, NNRTIs, and PIs in a large clinical cohort
-
DOI 10.1310/hct0801-9
-
Maggiolo F, Ripamonti D, Airoldi M, et al. Resistance costs and future drug options of antiretroviral therapies: analysis of the role of NRTIs, NNRTIs, and PIs in a large clinical cohort. HIV Clin Trials 2007; 8:9-18. (Pubitemid 46542905)
-
(2007)
HIV Clinical Trials
, vol.8
, Issue.1
, pp. 9-18
-
-
Maggiolo, F.1
Ripamonti, D.2
Airoldi, M.3
Callegaro, A.4
Arici, C.5
Ravasio, V.6
Bombana, E.7
Goglio, A.8
Suter, F.9
-
4
-
-
67649538485
-
-
DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents Updated 10 January 2011. Accessed 01 April 2011. Available from
-
DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. (Updated 10 January 2011. Accessed 01 April 2011.) Available from http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf
-
Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
-
-
-
6
-
-
52749083531
-
BHIVA Treatment Guidelines Writing Group. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
-
BHIVA Treatment Guidelines Writing Group. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Med 2008; 9:563-608.
-
(2008)
HIV Med
, vol.9
, pp. 563-608
-
-
-
8
-
-
33748955158
-
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
-
DOI 10.1016/j.jmb.2006.08.007, PII S0022283606009958
-
Kovalevsky AY, Liu F, Leshchenko S, et al. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol 2006; 363:161-173. (Pubitemid 44437563)
-
(2006)
Journal of Molecular Biology
, vol.363
, Issue.1
, pp. 161-173
-
-
Kovalevsky, A.Y.1
Liu, F.2
Leshchenko, S.3
Ghosh, A.K.4
Louis, J.M.5
Harrison, R.W.6
Weber, I.T.7
-
9
-
-
33144466093
-
Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M
-
DOI 10.1021/jm050943c
-
Kovalevsky AY, Tie Y, Liu F, et al. Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem 2006; 49:1379-1387. (Pubitemid 43271890)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.4
, pp. 1379-1387
-
-
Kovalevsky, A.Y.1
Tie, Y.2
Liu, F.3
Boross, P.I.4
Wang, Y.-F.5
Leshchenko, S.6
Ghosh, A.K.7
Harrison, R.W.8
Weber, I.T.9
-
10
-
-
19544386471
-
TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
-
DOI 10.1128/AAC.49.6.2314-2321.2005
-
De Meyer S, Azijn H, Surleraux D, et al. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother 2005; 49:2314-2321. (Pubitemid 40734460)
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, Issue.6
, pp. 2314-2321
-
-
De Meyer, S.1
Azijn, H.2
Surleraux, D.3
Jochmans, D.4
Tahri, A.5
Pauwels, R.6
Wigerinck, P.7
De Bethune, M.-P.8
-
11
-
-
45149083375
-
Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease
-
Sayer JM, Liu F, Ishima R, Weber IT, Louis JM. Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease. J Biol Chem 2008; 283:13459-13470.
-
(2008)
J Biol Chem
, vol.283
, pp. 13459-13470
-
-
Sayer, J.M.1
Liu, F.2
Ishima, R.3
Weber, I.T.4
Louis, J.M.5
-
12
-
-
35348960903
-
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization
-
DOI 10.1074/jbc.M703938200
-
Koh Y, Matsumi S, Das D, et al. Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem 2007; 282:28709-28720 (Pubitemid 47606016)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.39
, pp. 28709-28720
-
-
Koh, Y.1
Matsumi, S.2
Das, D.3
Amano, M.4
Davis, D.A.5
Li, J.6
Leschenko, S.7
Baldridge, A.8
Shioda, T.9
Yarchoan, R.10
Ghosh, A.K.11
Mitsuya, H.12
-
13
-
-
34047207229
-
Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: A pooled subgroup analysis of data from two randomised trials
-
DOI 10.1016/S0140-6736(07)60497-8, PII S0140673607604978
-
Clotet B, Bellos N, Molina JM, et al. Efficacy and safety of DRV-RTV at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials. Lancet 2007; 369:1169-1178. (Pubitemid 46541620)
-
(2007)
Lancet
, vol.369
, Issue.9568
, pp. 1169-1178
-
-
Clotet, B.1
Bellos, N.2
Molina, J.-M.3
Cooper, D.4
Goffard, J.-C.5
Lazzarin, A.6
Wohrmann, A.7
Katlama, C.8
Wilkin, T.9
Haubrich, R.10
Cohen, C.11
Farthing, C.12
Jayaweera, D.13
Markowitz, M.14
Ruane, P.15
Spinosa-Guzman, S.16
Lefebvre, E.17
-
14
-
-
34347329093
-
Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: A randomised controlled phase III trial
-
DOI 10.1016/S0140-6736(07)61049-6, PII S0140673607610496
-
Madruga JV, Berger D, McMurchie M, et al. Efficacy and safety of DRV-RTV compared with that of lopinavir-RTV at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial. Lancet 2007; 370:49-58. (Pubitemid 47023100)
-
(2007)
Lancet
, vol.370
, Issue.9581
, pp. 49-58
-
-
Madruga, J.V.1
Berger, D.2
McMurchie, M.3
Suter, F.4
Banhegyi, D.5
Ruxrungtham, K.6
Norris, D.7
Lefebvre, E.8
De Bethune, M.-P.9
Tomaka, F.10
De Pauw, M.11
Vangeneugden, T.12
Spinosa-Guzman, S.13
-
15
-
-
49649092719
-
Efficacy and safety of once-daily DRV/RTV versus lopinavir/RTV in treatmentnaive HIV-1-infected patients at week 48
-
Ortiz R, Dejesus E, Khanlou H, et al. Efficacy and safety of once-daily DRV/RTV versus lopinavir/RTV in treatmentnaive HIV-1-infected patients at week 48. AIDS 2008; 22:1389-1397.
-
(2008)
AIDS
, vol.22
, pp. 1389-1397
-
-
Ortiz, R.1
Dejesus, E.2
Khanlou, H.3
-
16
-
-
69449092725
-
Once-daily DRV/RTV vs lopinavir/RTV in treatment-naive, HIV-1-infected patients: 96-week analysis
-
Mills AM, Nelson M, Jayaweera D, et al. Once-daily DRV/RTV vs lopinavir/RTV in treatment-naive, HIV-1-infected patients: 96-week analysis. AIDS 2009; 23:1679-1688.
-
(2009)
AIDS
, vol.23
, pp. 1679-1688
-
-
Mills, A.M.1
Nelson, M.2
Jayaweera, D.3
-
17
-
-
59849127268
-
Update of the drug resistance mutations in HIV-1: December 2008
-
Johnson VA, Brun-Vézinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: December 2008. Top HIV Med 2008; 16:138-145.
-
(2008)
Top HIV Med
, vol.16
, pp. 138-145
-
-
Johnson, V.A.1
Brun-Vézinet, F.2
Clotet, B.3
-
18
-
-
41449098109
-
Resistance profile of darunavir: Combined 24-week results from the POWER trials
-
DOI 10.1089/aid.2007.0173
-
De Meyer S, Vangeneugden T, van Baelen B, et al. Resistance profile of DRV: combined 24-week results from the POWER trials. AIDS Res Hum Retroviruses 2008; 24:379-388. (Pubitemid 351457745)
-
(2008)
AIDS Research and Human Retroviruses
, vol.24
, Issue.3
, pp. 379-388
-
-
De Meyer, S.1
Vangeneugden, T.2
Van Baelen, B.3
De Paepe, E.4
Van Marck, H.5
Picchio, G.6
Lefebvre, E.7
De Bethune, M.-P.8
-
19
-
-
42149135585
-
Virological response to darunavir/ritonavir-based regimens in antiretroviral-experienced patients (PREDIZISTA Study)
-
Pellegrin I, Wittkop L, Joubert LM, et al. Virological response to DRV/RTV-based regimens in antiretroviral-experienced patients (PREDIZISTA study). Antivir Ther 2008; 13:271-279. (Pubitemid 351535378)
-
(2008)
Antiviral Therapy
, vol.13
, Issue.2
, pp. 271-279
-
-
Pellegrin, I.1
Wittkop, L.2
Joubert, L.M.3
Neau, D.4
Bollens, D.5
Bonarek, M.6
Girard, P.-M.7
Fleury, H.8
Winters, B.9
Saux, M.-C.10
Pellegrin, J.-L.11
Thiebaut, R.12
Breilh, D.13
-
20
-
-
60749130473
-
Mutations associated with virological response to DRV/RTV in HIV-1-infected protease inhibitor-experienced patients
-
Descamps D, Lambert-Niclot S, Marcelin AG, et al. Mutations associated with virological response to DRV/RTV in HIV-1-infected protease inhibitor-experienced patients. J Antimicrob Chemother 2009; 63:585-592.
-
(2009)
J Antimicrob Chemother
, vol.63
, pp. 585-592
-
-
Descamps, D.1
Lambert-Niclot, S.2
Marcelin, A.G.3
-
21
-
-
66349091714
-
Pattern and impact of emerging resistance mutations in treatment experienced patients failing DRV-containing regimen
-
Delaugerre C, Pavie J, Palmer P, et al. Pattern and impact of emerging resistance mutations in treatment experienced patients failing DRV-containing regimen. AIDS 2008; 22:1809-1813.
-
(2008)
AIDS
, vol.22
, pp. 1809-1813
-
-
Delaugerre, C.1
Pavie, J.2
Palmer, P.3
-
23
-
-
48749114368
-
-
Laboratory for Clinical and Evolutionary Virology, Rega Institute for Medical Research, Accessed 30 May 2010. Available from
-
Laboratory for Clinical and Evolutionary Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven. Rega algorithms. (Accessed 30 May 2010.) Available from http://www.rega.kuleuven.be/cev/index.php?id=30
-
Rega Algorithms
-
-
-
24
-
-
37349046370
-
Response to 'Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients' [6]
-
DOI 10.1097/QAD.0b013e3282f2be42, PII 0000203020080102000028
-
Picchio G, De Meyer S, de Béthune MP. Response to 'key amprenavir resistance mutations counteract dramatic efficacy of DRV in highly experienced patients'. AIDS 2008; 22:165-167. (Pubitemid 350294899)
-
(2008)
AIDS
, vol.22
, Issue.1
, pp. 165-167
-
-
Picchio, G.1
De Meyer, S.2
De Bethune, M.-P.3
-
26
-
-
0038238324
-
Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency vires type 1 drug resistance
-
DOI 10.1086/375355
-
De Luca A, Cingolani A, Di Giambenedetto S, et al. Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency virus type 1 drug resistance. J Infect Dis 2003; 187:1934-1943. (Pubitemid 36724492)
-
(2003)
Journal of Infectious Diseases
, vol.187
, Issue.12
, pp. 1934-1943
-
-
De Luca, A.1
Cingolani, A.2
Di, G.S.3
Trotta, M.P.4
Baldini, F.5
Rizzo, M.G.6
Bertoli, A.7
Liuzzi, G.8
Narciso, P.9
Murri, R.10
Ammassari, A.11
Perno, C.F.12
Antinori, A.13
-
27
-
-
79959573451
-
Improved interpretation and clinical validation of substitutions in HIV-1 protease predicting the virological response to DRV/RTV
-
De Luca A, Di Giambenedetto S, Marando F, et al. Improved interpretation and clinical validation of substitutions in HIV-1 protease predicting the virological response to DRV/RTV. Antivir Ther 2008; 13 Suppl 3:A104.
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
De Luca, A.1
Di Giambenedetto, S.2
Marando, F.3
|