Treatment of alopecia areata: "what is new on the horizon?"

Dermatologic Therapy

Volumn 24, Issue 3, 2011, Pages 364-368

  Hordinsky, Maria K ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

alopecia areata; clinical trials; genome wide association study (GWAS)

Indexed keywords

ADALIMUMAB; ALEFACEPT; BEXAROTENE; CORTICOSTEROID; CYCLOSPORIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DITHRANOL; EFALIZUMAB; ETANERCEPT; GAMMA INTERFERON ANTIBODY; INFLIXIMAB; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 15; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 6 ANTIBODY; METHOTREXATE; MINOXIDIL; NATURAL KILLER CELL RECEPTOR NKG2D; PHOSPHODIESTERASE IV INHIBITOR; PROTEIN KINASE SYK INHIBITOR; PSORALEN; SALAZOSULFAPYRIDINE; ULBP3 PROTEIN; UNCLASSIFIED DRUG;

ALOPECIA AREATA; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 6Q; DRUG EFFICACY; EXCIMER LASER; GENETIC ASSOCIATION; HAIR FOLLICLE; HUMAN; IMMUNE RESPONSE; NONHUMAN; PATIENT SAFETY; PHOTOCHEMOTHERAPY; PROTEIN EXPRESSION; QUALITY OF LIFE; SIGNAL TRANSDUCTION; SKIN BIOPSY; TREATMENT INDICATION; ULTRAVIOLET RADIATION;

ALOPECIA AREATA; CYTOKINES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GENOME-WIDE ASSOCIATION STUDY; GPI-LINKED PROTEINS; HAIR FOLLICLE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; T-LYMPHOCYTES;

EID: 79959569815     PISSN: 13960296     EISSN: 15298019     Source Type: Journal    
DOI: 10.1111/j.1529-8019.2011.01421.x     Document Type: Article

References (15)

1. Alkhalifah A, Alsantali A, Wang E, et al,. Alopecia areata update. J Am Acad Dermatol 2010: 62: 191-202.
2. Safavi KH, Muller SA, Suman VJ, et al,. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc 1995: 70: 628-633.
3. Delamere FM, Sladden MJ, Dobbins HM, et al,. Interventions for alopecia areata. Cochrane Database Syst Rev 2008: (2): Art. No.: CD004413. DOI: 10.1002/14651858.CD004413.pub2. (Pubitemid 351807319)
4. Messenger AG,. Management of alopecia areata. In:, Basow DS, ed. Up to date. Waltham, MA: UpToDate, 2011: Available at [Accessed June 3, 2011].
5. Whiting DA,. Histopathologic features of alopecia areata: a new look. Arch Dermatol 2003: 139 (12): 1555-1559. (Pubitemid 37523073)
6. Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS,. Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 1999: 101: 62-67.
7. Kang H, Wu W, Lo B, et al,. Hair follicles from alopecia areata patients exhibit alterations in immune privilege-associated gene expression in advance of hair loss. J Invest Dermatol 2010: 130 (11): 2535-2537.
8. Paus R, Ito N, Takigawa M, et al,. The hair follicle and immune privilege. J Invest Dermatol Symp Proc 2003: 8: 188-194. (Pubitemid 37222828)
9. Hordinsky MK, Caramori APA,. Alopecia areata. In:, Hordinsky M, McMichael A, eds. Hair and scalp diseases: medical, surgical and cosmetic treatments. London UK: Informa Healthcare, 2008: 92-105.
10. Hay IC, Jamieson M, Ormerod AD,. Randomized trial of aromatherapy. Successful treatment for alopecia areata. Arch Dermatol 1999: 135: 602-603. (Pubitemid 29222313)
11. Petukhova L, Duvic M, Hordinsky M, et al,. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 2010: 466: 113-117.
12. Freyschmidt-Paul P, McElwee KJ, Hoffmann R, Sundberg JP, Vitacolonna M, Kissling S,. Interferon g deficient mice are resistant to the development of alopecia areata. Br J Dermatol 2006; 155: 515-521. (Pubitemid 44215480)
13. Verstovsek S, Kantarjian H, Mesa RA, et al,. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor in myelfibrosis. N Engl J Med 2010: 363: 1117-1127.
14. Von Bubnoff D, Hentges AE, Bieber T, Zimmer MT,. Natural killer cells in atopic and autoimmune diseases of the skin. J Allergy Clin Immunol 2010: 125: 60-68.
15. Duvic M, Norris D, Christiano A, Hordinsky M, Price V,. Alopecia areata registry: an overview. J Investig Dermatol Symp Proc 2003: 8 (2): 219-212.