Hyperglycemia, hypoxia and their combination exert oxidative stress and changes in antioxidant gene expression: Studies on cultured rat embryos

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 92, Issue 3, 2011, Pages 231-239

  Ornoy, Asher ^a   Livshitz, Alicia ^a   Ergaz, Zivanit ^a   Stodgell, Chais J ^b   Miller, Richard K ^b  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Antioxidant gene expression; Hyperglycemia; Hypoxia; Rat embryo culture

Indexed keywords

ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; OXYGEN;

ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO GROWTH; ENZYME ACTIVITY; GENE EXPRESSION; HYPERGLYCEMIA; HYPOXIA; LIMB MALFORMATION; NERVOUS SYSTEM MALFORMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANOXIA; ANTIOXIDANTS; CATALASE; CULTURE MEDIA; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE PEROXIDASE; HYPERGLYCEMIA; MALE; OSMOLAR CONCENTRATION; OXIDATIVE STRESS; RATS; SOMITES; SUPEROXIDE DISMUTASE; TISSUE CULTURE TECHNIQUES; YOLK SAC;

ANIMALIA; RATTUS;

EID: 79959544402     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20313     Document Type: Article

References (35)

1. Adair TH, Montani JP, Guyton AC. 1988. Effects of intermittent hypoxia on structural vascular adaptation in chick embryos. Am J Physiol 254:H1194-H1199.
2. Biri A, Onan A, Devrim E, et al. 2006. Oxidant status in maternal and cord plasma and placental tissue in gestational diabetes. Placenta 27:327-332.
3. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Brown NA, Fabro S. 1981. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 24:65-78.
5. Casson IF, Clarke CA, Howard CV, et al. 1997. Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. BMJ 315:275-278.
6. Catrina SB, Okamoto K, Pereira T, Brismar K, Poellinger L. 2004. Hyperglycemia regulates hypoxia-inducible factor 1 protein stability and function. Diabetes 53:3226-3232.
7. Cederberg J, Siman CM, Eriksson UJ. 2001. Combined treatment with vitamin E and vitamin C decrease oxidative stress and improve fetal outcome in experimental diabetic pregnancy. Pediatr Res 49:755-762.
8. Chandel NS, Maltepe E, Goldwasser E, et al. 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95:11715-11720.
9. Chang TI, Horal M, Jain SK, et al. 2003. Oxidant regulation of gene expression and neural tube development: insights gained from diabetic pregnancy on molecular causes of neural tube defects. Diabetologia 46:538-545.
10. Coughlan PT, Vervaart PP, Permezel M, Georgiou HM, Rice GE. 2004. Altered placental oxidative stress status in gestational diabetes mellitus. Placenta 25:78-84.
11. Daskalakis G, Marinopoulos S, Krielesi V, et al. 2008. Placental pathology in women with gestational diabetes. Acta Obstet Gynecol Scand 87:403-407.
12. Eidem I, Stene LC, Henriksen T, et al. 2010. Congenital anomalies in newborns of women with type 1 diabetes: nationwide population-based study in Norway, 1999-2004. Acta Obstet Gynecol Scand 89:1403-1411.
13. Eriksson UJ, Borg LA, Forsberg H, Styrud J. 1991. Diabetic embryopathy: studies with animal and in vitro models. Diabetes 40:94-98.
14. Evers IM, Nikkels PG, Sikkema JM, Visser GH. 2003. Placental pathology in women with type 1 diabetes and in a control group with normal and large-for-gestational-age infants. Placenta 24:819-825.
15. Gheorghe CP, Mohan S, Oberg KC, Longo LD. 2007. Gene expression patterns in the hypoxic murine placenta: a role in epigenesis? Reprod Sci 14:223-233.
16. Kohen R, Nyska A. 2002. Oxidation of biological systems: oxidative stress phenomena, Antioxidants, Redox reaction and methods for their quantitation. Toxicol Pathol 30:620-650.
17. Leach L, Taylor A, Sciota F 2009. Vascular dysfunction in the diabetic placenta: causes and consequences. J Anat 215:69-76.
18. Li R, Chase M, Jung SK, Smith PJS, Loeken MR. 2005. Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress. Am J Physiol Endocrinol Metab 289:E591-E599.
19. Makhseed M, Mushini VM, Ahmed MA, Al-harmi J 2002. Placental pathology in relation to the white's classification of diabetes mellitus. Arch Gynecol Obstet 266:136-140.
20. McCord JM, Fridovich I. 1988. Superoxide dismutase: the first twenty years (1968-1988). Free Radic Biol Med 5:363-369.
21. Ornoy A 2007. Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reprod Toxicol 24:31-41.
22. Ornoy A, Rand SB, Bischitz N 2010. Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos. Birth Defects Res B Dev Reprod Toxicol 89:106-115.
23. Ornoy A, Zaken V, Kohen, R. 1999. The role of reactive oxygen species (ROS) in the diabetes-induced anomalies, in rat embryos in vitro: a reduction in antioxidant enzymes and low molecular weight antioxidants (LMWA) may be a causative factor for increased anomalies. Teratology 60:376-386.
24. Pavlinkova G, Salbaum JM, Keppen C. 2009. Maternal diabetes alters transcriptional programs in the developing embryo. BMC genomics.
25. Reece EA, Ilwoon Ji, Wu Y-K. 2006. Characterization of differential gene expression profiles in diabetic embryopathy using DNA microarray analysis. Obstet Gynecol 195:1075-1080.
26. Rosenzweig I 2003. Detrimental effects of hypoxia-reoxigenation injury on development of rat embryos during organogenesis in vitro. Croat Med J 44:157-160.
27. Sköld AC, Wellfelt K, Danielsson BR. 2001. Stage-specific skeletal and visceral defects of the Ikr-blocker almokalant: further evidence for teratogenicity via a hypoxia-related mechanism. Teratology 64:292-300.
28. Singh DK, Winocour P, Farmington K. 2008. Mechanism of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol 4:216-226.
29. Thurman RG, Ley HG, Scholz R. 1972. Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Eur J Biochem 25:420-430.
30. Webster WS, Abela D. 2007. The effect of hypoxia in development. Birth Defect Res C Embryo Today 81:215-228.
31. Williamson JR, Chang K, Frangos M, et al. 1993. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42:801-813.
32. Zaken V, Kohen R, Ornoy A. 2000. The development of the antioxidant defense mechanism in young rat embryos in vivo and in vitro. Early Pregnancy Biol Med 4:110-123.
33. Zaken V, Kohen R, Ornoy A. 2001. Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium. Teratology 64:33-44.
34. Zangen WS, Seonghun R, Ornoy A. 2006. The role of antioxidant enzymes and transcription factor NJ-kappa B in Diabetic embryopathy in the Cohen diabetic rat model. Birth Defects Research, part A. Clin Mol Teratol 76:107-114.
35. Zusman I, Yaffe P, Ornoy A. 1987. The effects of high sucrose diet and maternal diabetes on the ultrastructure of the visceral yolk sac endoderm in rat embryos developing in vivo and in vitro. Acta Anat 128:11-19.