Occurrence of medical co-morbidity in mild cognitive impairment: Implications for generalisation of MCI research

Age and Ageing

Volumn 40, Issue 4, 2011, Pages 501-507

  Stephan, Blossom C M ^a   Brayne, Carol ^a   Savva, George M ^a   Matthews, Fiona E ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dementia risk; Elderly; Health related co morbidity; Mild cognitive impairment (MCI)

Indexed keywords

AGED; ANEMIA; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; FOLLOW UP; HEALTH SURVEY; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

AGE FACTORS; AGED; AGING; ANALYSIS OF VARIANCE; ANEMIA; BIOMEDICAL RESEARCH; CHI-SQUARE DISTRIBUTION; COGNITION; COGNITION DISORDERS; COMORBIDITY; DEMENTIA; DISEASE PROGRESSION; FEMALE; GREAT BRITAIN; HUMANS; LOGISTIC MODELS; MALE; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 79959535373     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afr057     Document Type: Article

References (33)

1. Grundman M, Petersen RC, Ferris SH et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 2004; 61: 59-66.
2. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003; 18: 61-71.
3. Visser PJ, Scheltens P, Verhey FRJ. Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?. J Neurol Neurosurg Psychiatry 2005; 76: 1348-54.
4. Matthews FE, Stephan BCM, McKeith I, Bond J, Brayne C, MRC CFAS. Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?. J Am Geriatr Soc 2008; 56: 1424-33.
5. Mitchell AJ, Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia-meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 2009; 119: 252-65.
6. Mitnitski A, Skoog I, Song X et al. A vascular risk factor index in relation to mortality and incident dementia. Eur J Neurol 2006; 13: 514-21.
7. Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 2006; 5: 735-41.
8. Siuda J, Gorzkowska A, Patalong-Ogiewa M et al. From mild cognitive impairment to Alzheimer's disease-influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up. Neurol Neurochir Pol 2009; 43: 321-9.
9. Solfrizzi V, Panza F, Colacicco AM et al. Vascular risk factors, incidence of MCI, and rates of progression to dementia. Neurology 2004; 63: 1882-91.
10. Kivipelto M, Helkala EL, Hanninen T et al. Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 2001; 56: 1683-9.
11. Brayne C, McCracken C, Matthews FE. Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS). Int J Epidemiol 2006; 35: 1140-5.
12. Folstein M, Folstein S, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-98.
13. Copeland JR, Dewey ME, Griffiths-Jones HM. A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med 1986; 16: 89-99.
14. Roth M, Tym E, Mountjoy CQ et al. A standarized instrument for the diagnoses of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 1986; 149: 698-709.
15. Rose GA. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ 1962; 27: 645-58.
16. Copeland JR, Kelleher MJ, Kellett JM et al. A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule. I. Development and reliability. Psychol Med 1976; 6: 439-49.
17. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), 3rd edition. Washington, DC: APA, 1987.
18. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidencebased review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001; 56: 1133-42.
19. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56: 303-8.
20. Matthews FE, Stephan BCM, Bond J, McKeith I, Brayne C, MRC CFAS. Operationalisation of mild cognitive impairment: a graphical approach. PLoS Med 2007; 4: e304 doi:10.1371/journal.pmed.0040304.
21. Stephan BCM, Brayne C, McKeith I, Bond J, Matthews FE, MRC CFAS. Mild cognitive impairment in the older population: who is missed in classifications and does it matter?. Int J Geriatric Psychiatry 2008; 23: 863-71.
22. Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med 2002; 162: 2269-76.
23. Yip AG, Brayne C, Matthews FE. Risk factors for incident dementia in England and Wales: the Medical Research Council Cognitive Function and Ageing Study. A populationbased nested case-control study. Age Ageing 2006; 35: 154-60.
24. Grodstein F. Cardiovascular risk factors and cognitive function. Alzheimers Dement 2007; 3(SUPPL. 1): S16-22.
25. Corser W, Sikorskii A, Olomu A, Stommel M, Proden C, Holmes-Rovner M. Concordance between comorbidity data from patient self-report interviews and medical record documentation. BMC Health Serv Res 2008; 8: 85.
26. Simpson CF, Boyd CM, Carlson MC, Griswold ME, Guralnik JM, Fried LP. Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement. J Am Geriatr Soc 2004; 52: 123-7.
27. Zekry D, Herrmann FR, Grandjean R et al. Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing 2008; 37: 83-9.
28. Lyketsos CG, Toone L, Tschanz J et al. Population-Based Study of Medical Comorbidity in Early Dementia and "Cognitive Impairment, No Dementia (CIND)" : Association With Functional and Cognitive Impairment: The Cache County Study. Am J Geriatr Psychiatry 2005; 13: 656-64.
29. Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C. Dementia risk prediction in the population: are screening models accurate?. Nat Rev Neurol 2010; 6: 318-26.
30. Tervo S, Kivipelto M, Hanninen T et al. Incidence and risk factors for mild cognitive impairment: a populationbased three-year follow-up study of cognitively healthy elderly subjects. Dement Geriatr Cogn Disord 2004; 17: 196-203.
31. Ravaglia G, Forti P, Maioli F et al. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement Geriatr Cogn Disord 2006; 21: 51-8.
32. Deal JA, Carlson MC, Xue Q, Fried LP, Chaves PHM. Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: the Women's Health and Aging Study II. J Am Geriatr Soc 2009; 57: 1604-11.
33. Peters R, Burch L, Warner J, Beckett N, Poulter R, Bulpitt C. Haemoglobin, anaemia, dementia and cognitive decline in the elderly, a systematic review. BMC Geriatr 2008; 8: 18.