Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin

Bioscience, Biotechnology and Biochemistry

Volumn 75, Issue 6, 2011, Pages 1167-1173

  Nakagawa, Yu ^a,b   Kikumori, Masayuki ^a   Yanagita, Ryo C ^a,c   Murakami, Akira ^a   Tokuda, Harukuni ^d   Nagai, Hiroshi ^e   Irie, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

^e TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Aplog 1; Aplysiatoxin; Bryostatin; Protein kinase C; Tumor promoter

Indexed keywords

ANTI-PROLIFERATIVE; ANTI-TUMORS; ANTICANCER DRUG; APLOG-1; APLYSIATOXIN; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; BIOLOGICAL POTENCY; BIOLOGICAL RESPONSE; BRYOSTATIN; CANCER CELL GROWTH; DIESTERS; DIMETHYL GROUPS; EPSTEIN-BARR VIRUS; LOCAL HYDROPHOBICITY; PROTEIN KINASE C; STRUCTURAL FEATURE; TUMOR CELLS;

DISEASES; ENZYMES; GROWTH KINETICS; HYDROPHOBICITY; VIRUSES;

TUMORS;

ANTINEOPLASTIC AGENT; APLYSIATOXIN; CARCINOGEN; EPSTEIN BARR VIRUS EARLY ANTIGEN; EPSTEIN-BARR VIRUS EARLY ANTIGEN; FURAN DERIVATIVE; LYNGBYATOXIN; PHORBOL ESTER; PROTEIN KINASE C DELTA; SPIRO COMPOUND; SPIROKETAL; VIRUS ANTIGEN;

ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL PROLIFERATION; CHEMICAL PHENOMENA; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; HUMAN; METABOLISM; METHYLATION; NEOPLASM; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; VIROLOGY;

ANTICARCINOGENIC AGENTS; ANTIGENS, VIRAL; B-LYMPHOCYTES; CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPSTEIN-BARR VIRUS INFECTIONS; FURANS; HERPESVIRUS 4, HUMAN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYNGBYA TOXINS; METHYLATION; NEOPLASMS; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN KINASE C-DELTA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN HERPESVIRUS 4;

EID: 79959534894     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.110130     Document Type: Article

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