Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 3965-3972

  Luo, Weiming ^a   Yu, Qian Sheng ^a   Salcedo, Isidro ^a   Holloway, Harold W ^a   Lahiri, Debomoy K ^b   Brossi, Arnold ^c   Tweedie, David ^a   Greig, Nigel H ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

3 Substituted 2,6 dioxopiperidines; Dithiocarbamates; Iminium rearrangement; N substituted EM 12; Neurodegenerative diseases; Revlimid; Thalidomide; TNF inhibition

Indexed keywords

1 CHLOROMETHYL 3 (TERT BUTOXYCARBONYLAMINO) 2,6 DIOXOPIPERIDINE; 1 HYDROXYMETHYL 3 (TERT BUTOXYCARBONYLAMINO) 2,6 DIOXOPIPERIDINE; 2 (1 CHLOROMETHYL 2,6 DIOXOPIPERIDIN 3 YL)PHTHALIMIDINE; 2,6 DIOXOPIPERIDINE DERIVATIVE; 3 (1 OXO 3 IMINO 1,3 DIHYDRO 2H ISOINDOL 2 YL) 2,6 DIOXOPIPERIDINE; 3 (1,3 DIIMINO 1,3 DIHYDRO 2H ISOINDOL 1N YL) 2,6 DIOXOPIPERIDINE; 3 (4 AZA 1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL) 2,6 DIOXOPIPERIDINE; 3 (5 AZA 1,3 DIOXO 1,3 DIHYDRO 2H ISOINDOL 2 YL) 2,6 DIOXOPIPERIDINE; 3 (O BENZENEDISULFONIMID 2 YL) 2,6 DIOXOPIPERIDINE; 3 (PHTHALIMIDIN 2 YL) 2,6 DIOXOPIPERIDINE DERIVATIVE; 3 AMINO 1 CHLOROMETHYL 2,6 DIOXOPIPERIDINE TRIFLUOROACETATE; [3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2 YL) 2,6 DIOXOPIPERIDIN 1 YL]METHYL PIPERIDIN 1 CARBODITHIOATE; [3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2 YL) 2,6 DIOXOPIPERIDIN 1 YL]METHYLCYCLOHEXYLDITHIOCARBAMATE; LENALIDOMIDE; N (1,3 DIOTHIOXOPIPERIDIN 2 YL)METHYL 3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2YL) 2,6 DIOXOPIPERIDINE; N (1,3 DIOXOPIPERIDIN 2 YL)METHYL 3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2YL) 2,6 DIOXOPIPERIDINE; N DITHIOPHTHALIMIDOMETHYL 3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2YL) 2,6 DIOXOPIPERIDINE; N PHTHALIMIDOMETHYL 3 (1 OXO 1,3 DIHYDRO 1H ISOINDOL 2YL) 2,6 DIOXOPIPERIDINE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

ADDITION REACTION; ANIMAL CELL; ARTICLE; CELL STRAIN RAW 264.7; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MACROPHAGE; MOUSE; NONHUMAN; POLYMERIZATION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS;

ANIMALS; CELL LINE, TUMOR; DRUG DESIGN; MICE; PHTHALIMIDES; PIPERIDINES; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79959499714     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.029     Document Type: Article

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