Polarization transfer for sensitivity-enhanced MRS using a single radio frequency transmit channel

NMR in Biomedicine

Volumn 21, Issue 5, 2008, Pages 444-452

  Klomp, D W J ^a   Kentgens, A P M ^b   Heerschap, A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

13C MRS; Distortionless enhanced polarization transfer (DEPT); Multinuclear MR; Polarization transfer; Single channel double resonance

Indexed keywords

MAGNETIC RESONANCE SPECTROSCOPY; RADIO WAVES; RECONNAISSANCE AIRCRAFT; SPIN DYNAMICS;

13C MRS; CLINICAL SYSTEMS; DISTORTIONLESS ENHANCED POLARIZATION TRANSFER (DEPT); ENHANCED POLARIZATION; HUMAN BRAINS; HYPER-POLARIZED; IN-VIVO; MR SCANNERS; MULTINUCLEAR MR; PHANTOM MEASUREMENTS; POLARIZATION TRANSFER; RADIO FREQUENCIES; RADIO-FREQUENCY; RF ARCHITECTURE; SINGLE-CHANNEL DOUBLE RESONANCE; SPIN SYSTEMS;

POLARIZATION;

ARTICLE; BRAIN METABOLISM; BRAIN RADIOGRAPHY; CARBON NUCLEAR MAGNETIC RESONANCE; FREQUENCY MODULATION; INTERMETHOD COMPARISON; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHANTOM; POLARIZATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOFREQUENCY; RADIOSENSITIVITY; SIMULATION;

ADULT; ANISOTROPY; BIOMEDICAL TECHNOLOGY; CARBON ISOTOPES; ELEMENTARY PARTICLE INTERACTIONS; ENERGY TRANSFER; EQUIPMENT FAILURE ANALYSIS; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; RADIO WAVES; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPIN LABELS;

EID: 46049118413     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1208     Document Type: Article

References (28)

1. 13C NMR studies of compartmentalized cerebral carbohydrate metabolism. Neurochem Int 2002; 41: 143-154.
2. 13C MRS in vivo. NMR Biomed. 2003; 16: 38-369.
3. 13C enrichment of extracellular neurotransmitter glutamate in rat brain: combined mass spectrometry and NMR studies of neurotransmitter turnover and uptake into glia in vivo. Cell Mol Biol. 2003; 49(5): 819-836.
4. 19F magnetic resonance spectroscopy. Clin Cancer Res 1996; 2(2): 339-345.
5. 19F MRS at 3 Tesla. In: Proceedings of the 13th annual meeting of ISMRM, Miami 2005; p 128.
6. 3px MR spectroscopy. Magn Reson Med. 2003; 50(6): 1302-1306.
7. 3px nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest. 1992; 89(4): 1069-1075.
8. 13C. Boar J Radiol. 2003; 76: Spec No 2: S118-S127.
9. Gadian DG. NMR and its Applications to Living Systems. Oxford University Press Inc.: New York, 1995: 197.
10. Hartmann SR, Hahn EL. Nuclear double resonance in the rotating frame. Phys. Rev. 1962; 128(5): 2042-2053.
11. 13C MR spectroscopy on a clinical 1.5 T MR system. J Magn Reson. 1998; 135(1): 93-98.
12. 13C MR spectroscopy of the human brain at 3 Tesla. Magn Reson Med. 2006; 55(2): 271-278.
13. Morris GA, Freeman R. Enhancement of nuclear magnetic resonance signals by polarization transfer. J Am Chem Soc 1979; 101: 760-762.
14. 31p magnetic resonance spectra in vivo. Magn Reson Med. 2005; 54(5): 1065-1071.
15. Doddrell DM, Pegg DT, Bendall MR. Distortionless enhancement of NMR signals by polarization transfer. J. Magn. Reson. 1982; 48: 323-327.
16. 13C MRS of the human brain at 4 Tesla. Magn Reson Med. 1996; 36(5): 659-664.
17. 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla. Dev Neurosci. 1998; 20(4-5): 380-388.
18. 13C NMR spectroscopy of the rat brain in vivo at 9.4 T. Magn Reson Med. 2003; 50(4): 684-692.
19. Ordidge RJ, Connely A, Lohman JAB. Image-selected in vivo spectroscopy (ISIS): a new technique for spatially selective NMR spectroscopy. J. Magn. Reson. 1986; 66: 283-294.
20. 13C NMR spectroscopy of myo-inositol in the human brain in vivo. Magn Reson Med. 1992; 25(1): 204-210.
21. Mlynarik V, Gruber S, Moser E. Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla. NMR Biomed. 2001; 14(5): 325-331.
22. Helgstrand M, Allard P. QSim, a program for NMR simulations. J Biomol NMR. 2004; 30(1): 71-80.
23. 13C NMR: a comparison of proton decoupling and polarization transfer. Magn Reson Med. 1992; 28(1): 65-73.
24. Jakobsen HJ, Sorensen OW, Bildsoe H. Polarization transfer on spectrometers not equipped with a proton phase-shifter. J Magn Reson 1983; 51(1): 157-163.
25. Van Stapele RP, Heerschap A, Den Hollander JA. Method of and device for the volume-selective determination of an MR spectrum by means of selective polarization transfer pulse sequences. US Patent 4 987 369; 22 January 1991.
26. Watanabe H, Ishihara Y, Okamoto K, Oshio K, Kanamatsu T, Tsukada Y. In vivo 3D localized C-13 spectroscopy using modified INEPT and DEPT. J. Magn. Res. 1998; 134(2): 214-222.
27. 13C detection using PRESS. Magn Reson Med. 2005; 54(6): 1340-1350.
28. Henry PG, Marjanska M, Walls JD, Valette J, Gruetter R, Ugurbil K. Proton-observed carbon-edited NMR spectroscopy in strongly coupled second-order spin systems. Magn Reson Med. 2006; 55(2): 250-257.