Targeting X box-binding protein-1 (XBP1) enhances sensitivity of glioma cells to oxidative stress

Neuropathology and Applied Neurobiology

Volumn 37, Issue 4, 2011, Pages 395-405

  Liu, Y ^a   Zhang, X ^a   Liang, Y ^a   Yu, H ^a   Chen, X ^a   Zheng, T ^b   Zheng, B ^a   Wang, L ^a   Zhao, L ^a   Shi, C ^a,c   Zhao, S ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Glioma; Oxidative stress; ROS; XBP1

Indexed keywords

ARSENIC TRIOXIDE; CATALASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; X BOX BINDING PROTEIN 1; ANTIOXIDANT; DNA BINDING PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPSY; CANCER CELL CULTURE; CANCER SURGERY; CELL DEATH; CONTROLLED STUDY; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KNOCKOUT GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIOXIDANTS; ARSENIC TRIOXIDE; BRAIN TISSUE; CELL LINES; EXPRESSION LEVELS; GLIOMA; GLIOMA CELLS; HELA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; REACTIVE OXYGEN SPECIES; ROS; SYNERGISTIC EFFECT; UP-REGULATION; XBP1;

ARSENIC; CELL CULTURE; CELL DEATH; CELL MEMBRANES; HYDROGEN PEROXIDE; MAMMALS; MOLECULES; OXIDATIVE STRESS;

TUMORS;

ANTIOXIDANTS; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; GLIOMA; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 79959454033     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2010.01155.x     Document Type: Article

References (39)

1. Carpentier AF. Neuro-oncology: the growing role of chemotherapy in glioma. Lancet Neurol 2005; 4: 4-5
2. Taghian A, DuBois W, Budach W, Baumann M, Freeman J, Suit H. In vivo radiation sensitivity of glioblastomamultiforme. Int J Radiat Oncol Biol Phys 1995; 32: 99-104
3. Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D. Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 2002; 7: 492-508
4. Allalunis-Turner MJ, Zia PK, Barron GM, Mirzayans R, Day RS 3rd. Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line. Radiat Res 1995; 144: 288-93
5. Preuss M, Girnun GD, Darby CJ, Khoo N, Spector AA, Robbins ME. Role of antioxidant enzyme expression in the selective cytotoxic response of glioma cells to gammalinolenic acid supplementation. Free Radic Biol Med 2000; 28: 1143-56
6. Sun J, Chen Y, Li M, Ge Z. Role of antioxidant enzymes on ionizing radiation resistance. Free Radic Biol Med 1998; 24: 586-93
7. Mates JM, Perez-Gomez C, Nunez de Castro I. Antioxidant enzymes and human diseases. Clin Biochem 1999; 32: 595-603
8. Schumacker PT. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 2006; 10: 175-6
9. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51: 794-8
10. Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem 2006; 281: 13005-8
11. Oberley TD, Oberley LW. Antioxidant enzyme levels in cancer. Histol Histopathol 1997; 12: 525-35
12. Landriscina M, Maddalena F, Laudiero G, Esposito F. Adaptation to oxidative stress, chemoresistance, and cell survival. Antioxid Redox Signal 2009; 11: 2701-16
13. Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008; 14: 458-70
14. Clauss IM, Chu M, Zhao JL, Glimcher LH. The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core. Nucleic Acids Res 1996; 24: 1855-64
15. Sriburi R, Jackowski S, Mori K, Brewer JW. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 2004; 167: 35-41
16. Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003; 23: 7448-59
17. Zhang K, Kaufman RJ. The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 2006; 66: S102-9
18. Clauss IM, Gravallese EM, Darling JM, Shapiro F, Glimcher MJ, Glimcher LH. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn 1993; 197: 146-56
19. Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. An essential role in liver development for transcription factor XBP-1. Genes Dev 2000; 14: 152-7
20. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, GrusbyMJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001; 412: 300-7
21. Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res 2004; 64: 5943-7
22. Fujimoto T, Onda M, Nagai H, Nagahata T, Ogawa K, Emi M. Upregulation and overexpression of human X-box binding protein 1 (hXBP-1) gene in primary breast cancers. Breast Cancer 2003; 10: 301-6
23. Gomez BP, Riggins RB, Shajahan AN, Klimach U, Wang A, Crawford AC, Zhu Y, Zwart A, Wang M, Clarke R. Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines. FASEB J 2007; 21: 4013-27
24. Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y. Preventing oxidative stress: a new role for XBP1. Cell Death Differ 2009; 16: 847-57
25. Yoshida H, Oku M, Suzuki M, Mori K. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol 2006; 172: 565-75
26. Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem 2006; 281: 5852-60
27. Bross PF, Kane R, Farrell AT, Abraham S, Benson K, Brower ME, Bradley S, Gobburu JV, Goheer A, Lee SL, Leighton J, Liang CY, Lostritto RT, McGuinn WD, Morse DE, Rahman A, Rosario LA, Verbois SL, Williams G, Wang YC, Pazdur R. Approval summary for bortezomib for injection in the treatment of multiple myeloma. Clin Cancer Res 2004; 10: 3954-64
28. Zhao S, Zhang X, Zhang J, Zou H, Liu Y, Dong X, Sun X. Intravenous administration of arsenic trioxide encapsulated in liposomes inhibits the growth of C6 gliomas in rat brains. J Chemother 2008; 20: 253-62
29. Zhao S, Zhang J, Zhang X, Dong X, Sun X. Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep 2008; 35: 421-9
30. Zhao S, Tsuchida T, Kawakami K, Shi C, Kawamoto K. Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status. Int J Oncol 2002; 21: 49-55
31. Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003; 11: 619-33
32. Chu FF, Esworthy RS, Akman S, Doroshow JH. Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells. Nucleic Acids Res 1990; 18: 1531-9
33. Li JJ, Oberley LW, St Clair DK, Ridnour LA, Oberley TD. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 1995; 10: 1989-2000
34. Pu PY, Lan J, Shan SB, Huang EQ, Bai Y, Guo Y, Jiang DH. Study of the antioxidant enzymes in human brain tumors. J Neurooncol 1996; 29: 121-8
35. Fathallah-Shaykh HM. Genomic discovery reveals a molecular system for resistance to oxidative and endoplasmic reticulum stress in cultured glioma. Arch Neurol 2005; 62: 233-6
36. Woo SH, Park IC, Park MJ, Lee HC, Lee SJ, Chun YJ, Lee SH, Hong SI, Rhee CH. Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells. Int J Oncol 2002; 21: 57-63
37. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA.Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003; 23: 7198-209
38. Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid Redox Signal 2002; 4: 415-25
39. Matsukawa J, Matsuzawa A, Takeda K, Ichijo H. The ASK1-MAP kinase cascades in mammalian stress response. J Biochem 2004; 136: 261-5