Molecular basis of immunity to rickettsial infection conferred through outer membrane protein B

Infection and Immunity

Volumn 79, Issue 6, 2011, Pages 2303-2313

  Chan, Yvonne Gar Yun ^a,b   Riley, Sean Phillip ^a,b   Chen, Emily ^a   Martinez, Juan José ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b Howard T Ricketts Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN B; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ACTIVE IMMUNIZATION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG EFFICACY; EPITOPE MAPPING; FEMALE; GENETIC CONSERVATION; HUMORAL IMMUNITY; IMMUNITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE IMMUNIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; RICKETTSIA CONORII; RICKETTSIOSIS; SURVIVAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BOUTONNEUSE FEVER; CERCOPITHECUS AETHIOPS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FLOW CYTOMETRY; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED C3H; POLYMERASE CHAIN REACTION; RICKETTSIA CONORII; RICKETTSIAL VACCINES; VERO CELLS;

EID: 79959453421     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01324-10     Document Type: Article

References (55)

1. Ammerman, N. C., M. Beier-Sexton, and A. F. Azad. 2008. Laboratory maintenance of Rickettsia rickettsii. Curr. Protoc. Microbiol. 3:3A.5.
2. Anacker, R. L., R. H. List, R. E. Mann, S. F. Hayes, and L. A. Thomas. 1985. Characterization of monoclonal antibodies protecting mice against Rickettsia rickettsii. J. Infect. Dis. 151:1052-1060.
3. Anacker, R. L., R. E. Mann, and C. Gonzales. 1987. Reactivity of monoclonal antibodies to Rickettsia rickettsii with spotted fever and typhus group rickettsiae. J. Clin. Microbiol. 25:167-171.
4. Anacker, R. L., G. A. McDonald, R. H. List, and R. E. Mann. 1987. Neutralizing activity of monoclonal antibodies to heat-sensitive and heat-resistant epitopes of Rickettsia rickettsii surface proteins. Infect. Immun. 55:825-827.
5. Anigstein, L., M. N. Bader, and G. Young. 1943. Protective effect of separate inoculation of spotted fever virus and immune serum by intradermal route. Science 98:285-286.
6. Beaman, L., and C. L. Wisseman, Jr. 1976. Mechanisms of immunity in typhus infections. V. Demonstration of Rickettsia mooseri-specific antibodies in convalescent mouse and human serum cytophilic for mouse peritoneal macrophages. Infect. Immun. 14:1065-1070.
7. Beaman, L., and C. L. Wisseman, Jr. 1976. Mechanisms of immunity in typhus infections. VI. Differential opsonizing and neutralizing action of human typhus rickettsia-specific cytophilic antibodies in cultures of human macrophages. Infect. Immun. 14:1071-1076.
8. Bengtson, I. A., and N. H. Topping. 1942. Complement-fixation in rickettsial diseases. Am. J. Public Health Nations Health 32:48-58.
9. Chan, Y. G., M. M. Cardwell, T. M. Hermanas, T. Uchiyama, and J. J. Martinez. 2009. Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner. Cell Microbiol. 11:629-644.
10. Clements, M. L., et al. 1983. Reactogenicity, immunogenicity, and efficacy of a chick embryo cell-derived vaccine for Rocky Mountain spotted fever. J. Infect. Dis. 148:922-930.
11. Crocquet-Valdes, P. A., et al. 2001. Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis. Vaccine 20:979-988.
12. Croddy, E. A., J. J. Wirtz, and J. A. Larsen. 2005. Typhus (Rickettsia Prowazekii), p. 293. In E. A. Croddy and J. J. Wirtz (ed.), Weapons of mass destruction: an encyclopedia of worldwide policy, technology, and history, vol. 2. ABC-CLIO, Inc., Santa Barbara, CA.
13. Díaz-Montero, C. M., H. M. Feng, P. A. Crocquet-Valdes, and D. H. Walker. 2001. Identification of protective components of two major outer membrane proteins of spotted fever group Rickettsiae. Am. J. Trop. Med. Hyg. 65:371-378.
14. Driskell, L. O., et al. 2009. Directed mutagenesis of the Rickettsia prowazekii pld gene encoding phospholipase D. Infect. Immun. 77:3244-3248.
15. Dumler, J. S., C. L. Wisseman, Jr., P. Fiset, and M. L. Clements. 1992. Cell-mediated immune responses of adults to vaccination, challenge with Rickettsia rickettsii, or both. Am. J. Trop. Med. Hyg. 46:105-115.
16. DuPont, H. L., et al. 1973. Rocky Mountain spotted fever: a comparative study of the active immunity induced by inactivated and viable pathogenic Rickettsia rickettsii. J. Infect. Dis. 128:340-344.
17. Dyer, J. K., J. A. Bourque, and J. D. Steeves. 2005. The role of complement in immunological demyelination of the mammalian spinal cord. Spinal Cord 43:417-425.
18. Erdei, A., G. Fust, and J. Gergely. 1991. The role of C3 in the immune response. Immunol. Today 12:332-337.
19. Feng, H. M., T. Whitworth, J. P. Olano, V. L. Popov, and D. H. Walker. 2004. Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. Infect. Immun. 72:2222-2228.
20. Feng, H. M., T. Whitworth, V. Popov, and D. H. Walker. 2004. Effect of antibody on the rickettsia-host cell interaction. Infect. Immun. 72:3524-3530.
21. Fox, J. P., M. G. Everritt, T. A. Robinson, and D. P. Conwell. 1954. Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazekii (strain E); observations as to post-vaccination reactions, the relation of serologic response to size and route of infecting dose, and the resistance to challenge with virulent typhus strains. Am. J. Hyg. (London) 59:74-88.
22. Fox, J. P., M. E. Jordan, and H. M. Gelfand. 1957. Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazekii strain E. IV. Persistence of immunity and a note as to differing complementfixation antigen requirements in post-infection and post-vaccination sera. J. Immunol. 79:348-354.
23. Gambrill, M. R., and C. L. Wisseman, Jr. 1973. Mechanisms of immunity in typhus infections. 3. Influence of human immune serum and complement on the fate of Rickettsia mooseri within the human macrophages. Infect. Immun. 8:631-640.
24. Gilmore, R. D., Jr., N. Joste, and G. A. McDonald. 1989. Cloning, expression and sequence analysis of the gene encoding the 120 kD surface-exposed protein of Rickettsia rickettsii. Mol. Microbiol. 3:1579-1586.
25. Hackstadt, T., R. Messer, W. Cieplak, and M. G. Peacock. 1992. Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing. Infect. Immun. 60:159-165.
26. Harris, S. 1992. Japanese biological warfare research on humans: a case study of microbiology and ethics. Ann. N. Y. Acad. Sci. 666:21-52.
27. Jacob-Dubuisson, F., R. Fernandez, and L. Coutte. 2004. Protein secretion through autotransporter and two-partner pathways. Biochim. Biophys. Acta 1694:235-257.
28. Kenyon, R. H., R. A. Kishimoto, and W. C. Hall. 1979. Exposure of guinea pigs to Rickettsia rickettsii by aerosol, nasal, conjunctival, gastric, and subcutaneous routes and protection afforded by an experimental vaccine. Infect. Immun. 25:580-582.
29. Kenyon, R. H., L. S. Sammons, and C. E. Pedersen, Jr. 1975. Comparison of three Rocky Mountain spotted fever vaccines. J. Clin. Microbiol. 2:300-304.
30. Keysary, A., T. F. McCaul, and H. H. Winkler. 1989. Roles of the Fc receptor and respiratory burst in killing of Rickettsia prowazekii by macrophagelike cell lines. Infect. Immun. 57:2390-2396.
31. Kim, H. K., et al. 2010. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine 28: 6382-6392.
32. Lange, J. V., and D. H. Walker. 1984. Production and characterization of monoclonal antibodies to Rickettsia rickettsii. Infect. Immun. 46:289-294.
33. Li, H., B. Lenz, and D. H. Walker. 1988. Protective monoclonal antibodies recognize heat-labile epitopes on surface proteins of spotted fever group rickettsiae. Infect. Immun. 56:2587-2593.
34. McDonald, G. A., R. L. Anacker, and K. Garjian. 1987. Cloned gene of Rickettsia rickettsii surface antigen: candidate vaccine for Rocky Mountain spotted fever. Science 235:83-85.
35. McDonald, G. A., R. L. Anacker, R. E. Mann, and L. J. Milch. 1988. Protection of guinea pigs from experimental Rocky Mountain spotted fever with a cloned antigen of Rickettsia rickettsii. J. Infect. Dis. 158:228-231.
36. Reference deleted.
37. Oster, C. N., et al. 1977. Laboratory-acquired Rocky Mountain spotted fever. The hazard of aerosol transmission. N. Engl. J. Med. 297:859-863.
38. Quenee, L. E., et al. Amino acid residues 196-225 of LcrV represent a plague protective epitope. Vaccine 28:1870-1876.
39. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Hyg. 27:493-497.
40. Riley, S. P., et al. 2010. The Rickettsia conorii autotransporter protein Sca1 promotes adherence to nonphagocytic mammalian cells. Infect. Immun. 78:1895-1904.
41. Saslaw, S., and H. N. Carlisle. 1966. Aerosol infection of monkeys with Rickettsia rickettsii. Bacteriol. Rev. 30:636-645.
42. Silverman, D. J., and S. B. Bond. 1984. Infection of human vascular endothelial cells by Rickettsia rickettsii. J. Infect. Dis. 149:201-206.
43. Sumner, J. W., K. G. Sims, D. C. Jones, and B. E. Anderson. 1995. Protection of guinea-pigs from experimental Rocky Mountain spotted fever by immunization with baculovirus-expressed Rickettsia rickettsii rOmpA protein. Vaccine 13:29-35.
44. Topping, N. H. 1940. Rocky mountain spotted fever; treatment of infected laboratory animals with immune rabbit serum. U.S. Government Printing Office, Washington, DC.
45. Uchiyama, T., H. Kawano, and Y. Kusuhara. 2006. The major outer membrane protein rOmpB of spotted fever group rickettsiae functions in the rickettsial adherence to and invasion of Vero cells. Microbes Infect. 8:801-809.
46. Vishwanath, S., G. A. McDonald, and N. G. Watkins. 1990. A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. Infect. Immun. 58:646-653.
47. Walker, D. H. 1989. Rocky Mountain spotted fever: a disease in need of microbiological concern. Clin. Microbiol. Rev. 2:227-240.
48. Walker, D. H. 2009. The realities of biodefense vaccines against Rickettsia. Vaccine 27(Suppl. 4):D52-D55.
49. Walker, D. H., V. L. Popov, J. Wen, and H. M. Feng. 1994. Rickettsia conorii infection of C3H/HeN mice. A model of endothelial-target rickettsiosis. Lab. Invest. 70:358-368.
50. Wang, W., and B. A. Malcolm. 1999. Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange Site-Directed Mutagenesis. Biotechniques 26:680-682.
51. Weiss, E., and H. R. Dressler. 1962. Increased resistance to chloramphenicol in Rickettsia prowazekii with a note on failure to demonstrate genetic interaction among [sic]. J. Bacteriol. 83:409-414.
52. Williams, J. C., D. H. Walker, M. G. Peacock, and S. T. Stewart. 1986. Humoral immune response to Rocky Mountain spotted fever in experimentally infected guinea pigs: immunoprecipitation of lactoperoxidase 125Ilabeled proteins and detection of soluble antigens of Rickettsia rickettsii. Infect. Immun. 52:120-127.
53. Wilson, T., and J. Carson. 2001. Rapid, high-throughput extraction of bacterial genomic DNA from selective-enrichment culture media. Lett. Appl. Microbiol. 32:326-330.
54. Wisseman, C. L., Jr., A. D. Waddell, and W. T. Walsh. 1974. Mechanisms of immunity in typhus infections. IV. Failure of chicken embryo cells in culture to restrict growth of antibody-sensitized Rickettsia prowazekii. Infect. Immun. 9:571-575.
55. Xu, W., and D. Raoult. 1997. Distribution of immunogenic epitopes on the two major immunodominant proteins (rOmpA and rOmpB) of Rickettsia conorii among the other rickettsiae of the spotted fever group. Clin. Diagn. Lab. Immunol. 4:753-763.