Unique self-anhydride formation in the degradation of cytidine-5'- monophosphosialic acid (CMP-Neu5Ac) and cytidine-5'-diphosphosialic acid (CDP-Neu5Ac) and its application in CMP-sialic acid analogue synthesis

Chemistry - A European Journal

Volumn 17, Issue 27, 2011, Pages 7645-7655

  Kajihara, Yasuhiro ^a   Nishigaki, Sachiko ^b   Hanzawa, Daisuke ^b   Nakanishi, Go ^b   Okamoto, Ryo ^b   Yamamoto, Naoki ^b  

^a OSAKA UNIVERSITY   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

anhydrides; hydrolysis; isotopic labeling; reaction mechanisms; sialic acids

Indexed keywords

ACID DERIVATIVE; ACID HYDROLYSIS; ACID-LABILE; ANALOGUE SYNTHESIS; ANHYDRIDES; BIOLOGICAL ORGANISMS; DIPHOSPHATES; ESTER GROUPS; GLYCOSYLTRANSFERASES; ISOTOPIC LABELING; PHOSPHATE GROUP; PYROPHOSPHATE LINKAGE; REACTION MECHANISM; SIALIC ACIDS; SUGAR NUCLEOTIDES; SYNTHETIC METHODS;

AMIDES; CARBOXYLIC ACIDS; HYDROLYSIS; ISOTOPES; NUCLEOTIDES; SUGARS; SYNTHESIS (CHEMICAL);

ACID RESISTANCE;

CYTIDINE 5' DIPHOSPHOSIALIC ACID; CYTIDINE DIPHOSPHATE; CYTIDINE PHOSPHATE; CYTIDINE PHOSPHATE N ACETYLNEURAMINIC ACID; CYTIDINE PHOSPHATE SIALIC ACID; CYTIDINE-5'-DIPHOSPHOSIALIC ACID; CYTIDINE-5'-MONOPHOSPHOSIALIC ACID; DRUG DERIVATIVE; SIALIC ACID DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

CYTIDINE DIPHOSPHATE; CYTIDINE MONOPHOSPHATE; CYTIDINE MONOPHOSPHATE N-ACETYLNEURAMINIC ACID; MOLECULAR STRUCTURE; SIALIC ACIDS; STEREOISOMERISM;

EID: 79959415674     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201003387     Document Type: Article

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