Synthesis and biological evaluation of novel GSK-3β inhibitors as anticancer agents

Bulletin of the Korean Chemical Society

Volumn 32, Issue 6, 2011, Pages 2015-2020

  Choi, Min Jeong ^a,b   Oh, Da Won ^a   Jang, Jae Wan ^a,c   Cho, Yong Seo ^a   Seo, Seon Hee ^a   Jeong, Kyu Sung ^d   Ko, Soo Young ^b   Pae, Ae Nim ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Ewha Womans University   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

Anticancer; Glycogen synthase kinase 3 ; Inhibitor; Isoxazol indolin 2 one

Indexed keywords

ANTI-CANCER AGENTS; ANTICANCER; BINDING MODES; BIOLOGICAL EVALUATION; GLYCOGEN SYNTHASE KINASE-3; INHIBITOR; INHIBITORY ACTIVITY; ISOXAZOL-INDOLIN-2-ONE; TUMOR CELL LINES;

BINDING ENERGY; CELL CULTURE; TUMORS;

CRYSTAL STRUCTURE;

EID: 79959398638     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2011.32.6.2015     Document Type: Article

References (10)

1. Meijer, L.; Flajolet, M.; Greengard, P. Trends Pharmacol. Sci. 2004, 25, 471.
2. Phiel, C. J.; Wilson, C. A.; Lee, V. M.-Y.; Klein, P. S. Nature 2003, 423, 435.
3. (a) Sato, N.; Meijer, L.; Skaltsounis, L.; Greengard, P.; Brivanlou, A. H. Nat. Med. 2004, 10, 55.
4. (b) Thiel, A.; Heinonen, M.; Rintahaka, J.; Hallikainen, T.; Hemmes, A.; Dixon, D. A.; Haglund, C.; Ristimaki, A. J. Biol. Chem. 2006, 281, 4564.
5. (a) Michal, M.; Yoshiaki, K.; Hanneng, Z.; Jonathan, W.; Robert, M. K. Oncogene 2004, 23, 7882.
6. (b) Ougolkov, A. V.; Fernandez-Zapico, M. E.; Bilim, V. N.; Smyrk, T. C.; Chari, S. T.; Billadeau, D. D. Clin. Cancer Res. 2006, 12, 5074.
7. Ougolkov, A. V.; Fernandez-Zapico, M. E.; Savoy, D. N.; Urrutia, R. A.; Billadeau, D. D. Cancer Res. 2005, 65, 2076.
8. Liao, X.; Zhang, L.; Thrasher, J. B.; Du, J.; Li, B. Mol. Cancer Ther. 2003, 2, 1215.
9. Ghosh, J. C.; Altieri, D. C. Clin. Cancer Res. 2005, 11, 4580.
10. Kim, H. J.; Choo, H.; Cho, Y. S.; No, K. T.; Pae, A. N. Bioorg. Med. Chem. 2008, 16, 636.