Persistent hyperthyrotropinemia in congenital hypothyroidism: Successful combination treatment with levothyroxine and liothyronine

Journal of Pediatric Endocrinology and Metabolism

Volumn 24, Issue 5-6, 2011, Pages 347-350

  Strich, David ^a   Naugolny, Larisa ^a   Gillis, David ^b  

^a CLALIT HEALTH SERVICES   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

therapy; thyroid

Indexed keywords

LEVOTHYROXINE; LEVOTHYROXINE SODIUM; LIOTHYRONINE; LIOTHYRONINE SODIUM; THYROTROPIN; THYROXINE;

ARTICLE; CHILD; CLINICAL ARTICLE; CONGENITAL HYPOTHYROIDISM; DRUG DOSE REDUCTION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; LIOTHYRONINE BLOOD LEVEL; PERSISTENT HYPERTHYROTROPINEMIA; PRESCHOOL CHILD; RETROSPECTIVE STUDY; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

CHILD; CHILD, PRESCHOOL; CONGENITAL HYPOTHYROIDISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; PATIENT COMPLIANCE; RETROSPECTIVE STUDIES; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 79959384895     PISSN: 0334018X     EISSN: 0334018X     Source Type: Journal    
DOI: 10.1515/JPEM.2011.179     Document Type: Article

References (25)

1. Bernal J, Nunez J. Action of thyroid hormones in the brain. Eur J Endocrinol 1995;133:390-8.
2. Heyerdahl S, Kase BF, Lie SO. Intellectual development in children with congenital hypothyroidism in relation to recommended thyroxine treatment. J Pediatr 1991;118:850-7.
3. Morreale de Escobar G, Obregón MJ, Escobar del Rey F. Is neu-ropsychological development related to maternal hypothyroid-ism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000;85:3975-87. (Pubitemid 32055337)
4. Selva KA, Harper A, Downs A, Blasco PA, Lafranchi SH. Neu-rodevelopmental outcomes in congenital hypothyroidism: comparison of initial T4 dose and time to reach target T4 and TSH. J Pediatr 2005;147:775-80. (Pubitemid 41774832)
5. Bongers-Schokking JJ, de Muinck Keizer-Schrama SM. Influence of timing and dose of thyroid hormone replacement on mental, psychomotor, and behavioral development in children with congenital hypothyroidism. J Pediatr 2005;147:768-74. (Pubitemid 41774831)
6. Salerno M, Militerni R, Bravaccio C, Micillo M, Capalbo D, et al. Effect of different starting doses of levothyroxine on growth and intellectual outcome at four years of age in congenital hypothy-roidism. Thyroid 2002;12:45-52. (Pubitemid 34106716)
7. Ng SM, Anand D, Weindling AM. High versus low dose of initial thyroid hormone replacement for congenital hypothyroidism. Cochrane Database Syst Rev 2009;1:CD006972.
8. Rose SR, Brown RS, Foley T, Kaplowitz PB, Kaye CI, et al. Update of newborn screening and therapy for congenital hypothy-roidism. Pediatrics 2006;117:2290-303. (Pubitemid 46071281)
9. Gruters A, Krude H. Update on the management of congenital hypothyroidism. Horm Res 2007;68(suppl 5):107-11.
10. Pilo A, Lervasi G, Vitck F, Perdeghini M, Cazzuola F, et al. Thyroi-dal and peripheral production of 3, 5, 3'-triiodothyronine in humans by multicompartmental analysis. Am J Physiol 1990;258: E715-26. (Pubitemid 20142356)
11. Escobar-Morreale HF, Escobar del Rey F, Obregon MJ, Morreale de Escobar G. Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroi-dectomized rat. Endocrinology 1996;137:2490-502. (Pubitemid 26155786)
12. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodenases. Endocr Rev 2002;23:38-89. (Pubitemid 34185306)
13. Chiamelora MI, Wondisford FE. Minireview: thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology 2009;150:1091-6.
14. Conrad SC, Chiu H, Silverman BL. Soy formula complicates management of congenital hypothyroidism. Arch Dis Child 2004;89:37-40. (Pubitemid 38122005)
15. Morris JC. Clinical question: how do you approach the problem of TSH elevation in a patient on high-dose thyroid hormone replacement? Clin Endocrinol 2009;70:671-3.
16. Hindmarsh PC. Optimisation of thyroxine dose in congenital hypothyroidism. Arch Dis Child 2002;86:73-5. (Pubitemid 34123840)
17. Cassio A, Cacciari E, Cicognani A, Damiani G, Missiroli G, et al. Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? Pediatrics 2003;111:1055-60. (Pubitemid 36542621)
18. Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ. Eff ects of thyroxine as compared with thyroxine and triiodo-thyronine in patients with hypothyroidism. N Engl J Med 1999;340:424-9. (Pubitemid 29084773)
19. Nygaard B, Jensen WE, Kvetny J, Jarlov A, Farber J. Effect of combination therapy with thyroxine (T4) and 3, 5, 3'-triiodothy-ronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomized cross-over study. Eur J Endocrinol 2009;161:895-902.
20. Grozinsky-Glasberg S, Fraser A, Nahshoni E, Weizman A, Leibovici L. Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 2006;91:2592-9. (Pubitemid 44024623)
21. Wiersinga WM. Do we need still more trials on T4 and T3 combination therapy in hypothyroidism? Eur J Endocrinol 2009; 161:955-9.
22. Akcay T, Turan S, Guran T, Unluguzel G, Haklar G, et al. T4 plus T3 treatment in children with hypothyroidism and inappropriately elevated thyroid-stimulating hormone despite euthyroid-ism on T4 treatment. Horm Res Paediatr 2010;73:108-14.
23. Drugs.com. FDA professional drug information. Available from: http://www.drugs.com.
24. Stevenson RE, Schwartz CE. The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome. Best Pract Res Clin Endorinol Metab 2007;21:307-21. (Pubitemid 46888197)
25. Fisher DA, Schoen EJ, La Franchi S, Mandel SH, Nelson JC, et al. The hypothalamic-pituitary-thyroid negative feedback control axis in children with treated congenital hypothyroidism. J Clin Endocrinol Metab 2000;85:2722-7. (Pubitemid 32269141)