Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis

Parasitology Research

Volumn 108, Issue 6, 2011, Pages 1507-1512

  Okeola, Valeelat O ^a   Adaramoye, Oluwatosin A ^a   Nneji, Chiaka M ^a   Falade, Catherine O ^a   Farombi, E Olatunde ^a   Ademowo, Olusegun G ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CHLOROQUINE; ERYTHROCYTE ENZYME; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; NIGELLA SATIVA EXTRACT; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE COUNT; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPID PEROXIDATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARASITE CLEARANCE; PLANT SEED; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; PLASMODIUM YOELLI NIGERIENSIS; PRIORITY JOURNAL; TREATMENT DURATION;

ANIMALS; ANTIMALARIALS; ANTIOXIDANTS; CATALASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALARIA; MALONDIALDEHYDE; METHANOL; MICE; NIGELLA SATIVA; PHYTOTHERAPY; PLANT EXTRACTS; PLASMODIUM YOELII; REACTIVE OXYGEN SPECIES; SEEDS; SUPEROXIDE DISMUTASE;

MUS; NIGELLA SATIVA; PLASMODIUM YOELII;

EID: 79959380543     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-010-2204-4     Document Type: Article

References (35)

1. Aebi H (1974) Methods of enzymatic analysis. In: Bergmeyer HV (ed) catalase estimation. Verlag Chemic, New York, pp 673-684
2. EO Ajaiyeoba OO Abiodun MO Falade NO Ogbole JS Ashidi CT Happi DO Akinboye 2006 In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine Phytomedicine 13 295 298 (Pubitemid 43255332)
3. TB Al-Naggar MP Gomez-Serranillos ME Carretero AM Villar 2003 Neuropharmacological activity of Nigella Sativa L. extracts J Ethnopharmacol 88 63 68 (Pubitemid 36945350)
4. S Areekul Y Boonme 1986 Catalase activity in red cell and liver of mice infected with Plasmodium berghei Southeast Asian J Trop Med Public Health 17 48 52
5. M Burits F Bucar 2000 Antioxidant activity of Nigella sativa L. essential oil Phytother Res 14 323 328 (Pubitemid 30655515)
6. D Butler J Maurice C O'Brien 1997 Time to put malaria control on the global agenda Nature 386 535 536
7. MH Daba MS Abdel-Rahman 1998 Hepatoprotective activity of thymoquinone in isolated rat hepatocytes Toxicol Lett 95 23 29
8. M El-Dakhakhny M Barakat M Abd-El-Halim SM Aly 2000 Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats J Ethnopharmacol 72 299 304
9. ES El-Daly 1998 Protective effect of cysteine and Vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats J Pharm Belg 53 87 95
10. OA El-Shabrawy SA Nada 1996 Biological evaluation of multicomponent tea used as hypoglycemic in rats Fitoterapia 67 99 102 (Pubitemid 26173124)
11. KEH El-Tahir MMS Ashour MM Al-Harbi 1993 The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action Gen Pharmacol 24 1115 1122 (Pubitemid 23283079)
12. TO Elufioye JM Agbedahunsi 2004 Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo J Ethnopharmacol 93 167 171 (Pubitemid 38962402)
13. DS Fabricant NR Farnsworth 2001 The value of plants used in traditional medicine for drug discovery Environ Health Perspect 109 69 75 (Pubitemid 32303231)
14. EO Farombi YY Shyntum GO Emerole 2003 Influence of chloroquine treatment and Plasmodium falciparum malaria infection on some enzymatic and non-enzymatic antioxidant defense indices in humans Drug Chem Toxicol 26 59 71 (Pubitemid 36287834)
15. MC Gessler MH Nkunya LB Mwasumbi M Heinrich M Tanner 1994 Screening Tanzanian medicinal plants for antimalarial activity Acta Trop 56 65 77
16. AG Gornall CJ Bardawill MM David 1949 Determination of serum proteins by means of the biuret reaction J Biol Chem 177 751 766
17. WH Habig MJ Pabst WB Jakoby 1974 Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation J Biol Chem 249 7130 7139
18. PJ Houghton R Zarka B Heras RS Hoult 1995 Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation Planta Med 61 33 36
19. DJ Jollow JR Mitchell N Zampaglione JR Gillette 1974 Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite Pharmacol 12 251 271
20. T Khanna FA Zaidi PC Dandiya 1993 CNS and analgesic studies on Nigella sativa Fitoterapia 64 407 410 (Pubitemid 23351589)
21. LM Lautenbacher 1997 Schwarzkümmelöl Dtsch Apoth Ztg 137 68 69
22. K Lüersen RD Walter S Müller 2000 Plasmodium falciparum infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione Biochem J 346 545 552 (Pubitemid 30148144)
23. MR Mahmoud HS El-Abhar S Saleh 2002 The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice J Ethnopharmacol 79 1 11 (Pubitemid 34017233)
24. JM McCord I Fridovich 1969 Superoxide dismutase, an enzymatic function for erythrocuperin J Biol Chem 244 6049 6055
25. F Mouhajir JA Pedersen M Rejdali GHN Towers 1999 Antimicrobial thymohydroquinones of Moroccan Nigella sativa seeds detected by electron spin resonance Pharm Biol 37 391 395 (Pubitemid 30160598)
26. FW Muregi SC Chhabra EN Njagi CC Langàt-Thoruwa WM Njue AS Orago SA Omar IO Ndiege 2003 In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects J Ethnopharmacol 84 235 239 (Pubitemid 36324262)
27. A Mutabagani SAM El-Mahdy 1997 A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone in rats Saudi Pharm J 5 110 113 (Pubitemid 27438156)
28. OA Ogunbayo RA Adisa OG Ademowo OO Olorunsogo 2006 Incidence of chloroquine induced oxidative stress in the blood of rabbit Intl J Pharmacol 2 121 125
29. G Pasvol 1998 The treatment of falciparum malaria in African children Afr Health 20
30. JR Rodrigues ND Gamboa 2009 Effect of dequalinium on the oxidative stress in Plasmodium berghei-infected erythrocytes Parasitol Res 104 1491 1496
31. Türkdoǧan MK, Ozbek H, Yener Z, Tuncer I, Uygan I, Ceylan E (2003) The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride-induced hepatotoxicity in rats. Phytother Res 17:942-946 (Pubitemid 37152764)
32. R Varshney RK Kale 1990 Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes Int J Radiat Biol 58 733 743 (Pubitemid 20346842)
33. H Wiseman B Halliwell 1996 Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer Biochem J 313 17 29 (Pubitemid 26013419)
34. A Zaoui Y Cherrah MA Lacaille-Dubois A Settaf H Amarouch M Hassar 2000 Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat Therapie 55 379 382 (Pubitemid 30481173)
35. A Zaoui Y Cherrah K Alaoui N Mahassine H Amarouch M Hassar 2002 Effects of Nigella sativa fixed oil on blood homeostasis in rat J Ethnopharmacol 79 23 26 (Pubitemid 34017236)