Safety and tolerability of antiretrovirals during pregnancy

Infectious Diseases in Obstetrics and Gynecology

Volumn 2011, Issue , 2011, Pages

  Weinberg, Adriana ^a,b   Forster Harwood, Jeri ^a   Davies, Jill ^b   McFarland, Elizabeth J ^a   Pappas, Jennifer ^c   Kinzie, Kay ^b   Barr, Emily ^a   Paul, Suzanne ^a   Salbenblatt, Carol ^c   Soda, Elizabeth ^a   Vazquez, Anna ^a   Levin, Myron J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO HOSPITAL   (United States)

^c CHILDREN S HOSPITAL COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMYLASE; ANTIRETROVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; ZIDOVUDINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; AMYLASE BLOOD LEVEL; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHOLESTASIS; DISEASE SEVERITY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; HEMATOLOGIC DISEASE; HEPATOBILIARY DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; LIVER FUNCTION TEST; MEDICAL RECORD REVIEW; NEUTROPENIA; PREGNANCY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; THROMBOCYTOPENIA; VIRUS TRANSMISSION; ADULT; BLOOD; DISEASE TRANSMISSION; DRUG COMBINATION; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; PREGNANCY COMPLICATION; RISK FACTOR; VERTICAL TRANSMISSION; VIROLOGY;

ADULT; ANTI-RETROVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 79959361506     PISSN: 10647449     EISSN: 10980997     Source Type: Journal    
DOI: 10.1155/2011/867674     Document Type: Article

References (46)

1. Thorne C., Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy Clinical Infectious Diseases 2005 40 3 458 465 (Pubitemid 40216516)
2. Townsend C. L., Cortina-Borja M., Peckham C. S., De Ruiter A., Lyall H., Tookey P. A., Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 20002006 AIDS 2008 22 8 973 981 (Pubitemid 351652248)
3. Warszawski J., Tubiana R., Le Chenadec J., Blanche S., Teglas J. P., Dollfus C., Faye A., Burgard M., Rouzioux C., Mandelbrot L., Mother-to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort AIDS 2008 22 2 289 299
4. Cooper E. R., Charurat M., Burns D. N., Blattner W., Hoff R., Trends in antiretroviral therapy and mother-infant transmission of HIV Journal of Acquired Immune Deficiency Syndromes 2000 24 1 45 47 (Pubitemid 30447805)
5. Dorenbaum A., Cunningham C. K., Gelber R. D., Culnane M., Mofenson L., Britto P., Rekacewicz C., Newell M. L., Dclfraissy J. F., Cunningham-Schrader B., Mirochnick M., Sullivan J. L., Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial Journal of the American Medical Association 2002 288 2 189 198 (Pubitemid 34755279)
6. Antiretroviral-Pregnancy-Registry-Steering-Committee. Antiretroviral Pregnancy Registry International. Interim Report for 1 January 1989 through 31 July 2009, 2009, http://www.apregistry.com/
7. Company B-MS. Healthcare Provider Important Drug Warning Letter, 2001
8. Hitti J., Frenkel L. M., Stek A. M., Nachman S. A., Baker D., Gonzalez-Garcia A., Provisor A., Thorpe E. M., Paul M. E., Foca M., Gandia J., Huang S., Wei L. J., Stevens L. M., Watts D. H., McNamara J., Maternal toxicity with continuous nevirapine in pregnancy results from PACTG 1022 Journal of Acquired Immune Deficiency Syndromes 2004 36 3 772 776 (Pubitemid 38859341)
9. Kontorinis N., Dieterich D. T., Toxicity of non-nucleoside analogue reverse transcriptase inhibitors Seminars in Liver Disease 2003 23 2 173 181 (Pubitemid 36666686)
10. Ouyang D. W., Brogly S. B., Lu M., Shapiro D. E., Hershow R. C., French A. L., Leighty R. M., Thompson B., Tuomala R. E., Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals AIDS 2010 24 1 109 114
11. Ouyang D. W., Shapiro D. E., Lu M., Brogly S. B., French A. L., Leighty R. M., Thompson B., Tuomala R. E., Hershow R. C., Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure AIDS 2009 23 18 2425 2430
12. Tarantal A. F., Marthas M. L., Shaw J. P., Cundy K., Bischofberger N., Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1999 20 4 323 333 (Pubitemid 29143025)
13. Van Rompay K. K. A., Brignolo L. L., Meyer D. J., Jerome C., Tarara R., Spinner A., Hamilton M., Hirst L. L., Bennett D. R., Canfield D. R., Dearman T. G., Von Morgenland W., Allen P. C., Valverde C., Castillo A. B., Martin R. B., Samii V. F., Bendele R., Desjardins J., Marthas M. L., Pedersen N. C., Bischofberger N., Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques Antimicrobial Agents and Chemotherapy 2004 48 5 1469 1487 (Pubitemid 38544348)
14. Cotter A. M., Garcia A. G., Duthely M. L., Luke B., O'Sullivan M. J., Is antiretroviral therapy during pregnancy associated with an increased risk of preterm delivery, low birth weight, or stillbirth? Journal of Infectious Diseases 2006 193 9 1195 1201
15. Ekouevi D. K., Coffie P. A., Becquet R., Tonwe-Gold B., Horo A., Thiebaut R., Leroy V., Blanche S., Dabis F., Abrams E. J., Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Cte d'Ivoire AIDS 2008 22 14 1815 1820
16. Kourtis A. P., Bansil P., McPheeters M., Meikle S. F., Posner S. F., Jamieson D. J., Hospitalizations of pregnant HIV-infected women in the USA prior to and during the era of HAART, 19942003 AIDS 2006 20 14 1823 1831 (Pubitemid 44358900)
17. Kourtis A. P., Schmid C. H., Jamieson D. J., Lau J., Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis AIDS 2007 21 5 607 615
18. Tuomala R. E., Shapiro D. E., Mofenson L. M., Bryson Y., Culnane M., Hughes M. D., O'Sullivan M. J., Scott G., Stek A. M., Wara D., Bulterys M., Antiretroviral therapy during pregnancy and the risk of an adverse outcome New England Journal of Medicine 2002 346 24 1863 1870 (Pubitemid 34603030)
19. Tuomala R. E., Watts H., Li D., Vajaranant M., Pitt J., Hammill H., Landesman S., Zorrilla C., Thompson B., Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy Journal of Acquired Immune Deficiency Syndromes 2005 38 4 449 473 (Pubitemid 40381556)
20. Cunningham C. K., Chaix M. L., Rekacewicz C., Britto P., Rouzioux C., Gelber R. D., Dorenbaum A., Delfraissy J. F., Bazin B., Mofenson L., Sullivan J. L., Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316 Journal of Infectious Diseases 2002 186 2 181 188 (Pubitemid 34765505)
21. Duran A. S., Losso M. H., Salomn H., Harris D. R., Pampuro S., Soto-Ramirez L. E., Duarte G., De Souza R. S., Read J. S., Drug resistance among HIV-infected pregnant women receiving antiretrovirals for prophylaxis AIDS 2007 21 2 199 205 (Pubitemid 46036928)
22. Lyons F. E., Coughlan S., Byrne C. M., Hopkins S. M., Hall W. W., Mulcahy F. M., Emergence of antiretroviral resistance in HIV-positive women receiving combination antiretroviral therapy in pregnancy AIDS 2005 19 1 63 67 (Pubitemid 40111019)
23. Overton E. T., Sungkanuparph S., Nurutdinova D., Powderly W. G., Antiretroviral resistance among HIV-positive pregnant women who have antiretroviral experience from previous pregnancy AIDS 2005 19 13 1439 (Pubitemid 41800686)
24. Weinberg A., Forster-Harwood J., McFarland E. J., Pappas J., Davies J. K., Kinzie K., Barr E. A., Paul S. M., Salbenblatt C. R., Soda E., Vazquez A., Levin M. J., Resistance to antiretrovirals in HIV-infected pregnant women Journal of Clinical Virology 2009 45 1 39 42
25. Gingelmaier A., Eberle J., Kost B. P., Bogner J. R., Hofmann J., Weissenbacher T., Kstner R., Friese K., Weizsaecker K., Protease inhibitor-based antiretroviral prophylaxis during pregnancy and the development of drug resistance Clinical Infectious Diseases 2010 50 6 890 894
26. Weinberg A., Harwood J. E. F., McFarland E. J., Pappas J., Davies J., Kinzie K., Barr E., Paul S., Salbenblatt C., Soda E., Vazquez A., Peloquin C. A., Levin M. J., Kinetics and determining factors of the virologic response to antiretrovirals during pregnancy Infectious Diseases in Obstetrics and Gynecology 2009 2009
27. Mandelbrot L., Landreau-Mascaro A., Rekacewicz C., Berrebi A., Bnifla J. L., Burgard M., Lachassine E., Barret B., Chaix M. L., Bongain A., Ciraru-Vigneron N., Crenn-Hbert C., Delfraissy J. F., Rouzioux C., Mayaux M. J., Blanche S., Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1 Journal of the American Medical Association 2001 285 16 2083 2093 (Pubitemid 32367825)
28. Watts D. H., Balasubramanian R., Maupin R. T., Delke I., Dorenbaum A., Fiore S., Newell M. L., Delfraissy J. F., Gelber R. D., Mofenson L. M., Culnane M., Cunningham C. K., Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316 American Journal of Obstetrics and Gynecology 2004 190 2 506 516 (Pubitemid 38249253)
29. Timmermans S., Tempelman C., Godfried M. H., Nellen J., Dieleman J., Sprenger H., Schneider M. E. E., De Wolf F., Boer K., Van Der Ende M. E., Nelfinavir and nevirapine side effects during pregnancy AIDS 2005 19 8 795 799 (Pubitemid 40834749)
30. Connor E. M., Sperling R. S., Gelber R., Kiselev P., Scott G., O'Sullivan M. J., Vandyke R., Bey M., Shearer W., Jacobson R. L., Jimenez E., O'Neill E., Bazin B., Delfraissy J.-F., Culnane M., Coombs R., Elkins M., Moye J., Stratton P., Balsley J., Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment New England Journal of Medicine 1994 331 18 1173 1180 (Pubitemid 24331334)
31. Bae W. H., Wester C., Smeaton L. M., Shapiro R. L., Lockman S., Onyait K., Thior I., Essex M., Hematologic and hepatic toxicities associated with antenatal and postnatal exposure to maternal highly active antiretroviral therapy among infants AIDS 2008 22 13 1633 1640
32. Le Chenadec J., Mayaux M. J., Guihenneuc-Jouyaux C., Blanche S., Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants AIDS 2003 17 14 2053 2061 (Pubitemid 37297153)
33. Mussi-Pinhata M. M., Rego M. A. C., Freimanis L., Kakehasi F. M., Machado D. M., Cardoso E. M., Read J. S., Maternal antiretrovirals and hepatic enzyme, hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants: the NISDI perinatal study Pediatric Infectious Disease Journal 2007 26 11 1032 1037 (Pubitemid 350287586)
34. Foster C., Lyall H., Olmscheid B., Pearce G., Zhang S., Gibb D. M., Tenofovir disoproxil fumarate in pregnancy and prevention of mother-to-child transmission of HIV-1: is it time to move on from zidovudine? HIV Medicine 2009 10 7 397 406
35. Lyseng-Williamson K. A., Reynolds N. A., Plosker G. L., Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection Drugs 2005 65 3 413 432 (Pubitemid 40227461)
36. Mallal S., Nolan D., Witt C., Masel G., Martin A. M., Moore C., Sayer D., Castley A., Mamotte C., Maxwell D., James I., Christiansen F. T., Association between presence of HLA-B5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir Lancet 2002 359 9308 727 732 (Pubitemid 34215071)
37. Domingo P., Cabeza M. C., Pruvost A., Salazar J., Maria D. M. G., Mateo M. G., Domingo J. C., Fernandez I., Villarroya F., Muoz J., Vidal F., Baiget M., Relationship between HIV/highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome and stavudine-triphosphate intracellular levels in patients with stavudine-based antiretroviral regimens Clinical Infectious Diseases 2010 50 7 1033 1040
38. Hurst M., Noble S., Stavudine: an update of its use in the treatment of HIV infection Drugs 1999 58 5 919 949
39. Chi B. H., Mwango A., Giganti M., Mulenga L. B., Tambatamba-Chapula B., Reid S. E., Bolton-Moore C., Chintu N., Mulenga P. L., Stringer E. M., Sheneberger R., Mwaba P., Stringer J. S. A., Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia Journal of Acquired Immune Deficiency Syndromes 2010 54 1 63 70
40. Elzi L., Marzolini C., Furrer H., Ledergerber B., Cavassini M., Hirschel B., Vernazza P., Bernasconi E., Weber R., Battegay M., Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008 Archives of Internal Medicine 2010 170 1 57 65
41. Nightingale S. L., From the food and drug administration The Journal of the American Medical Association 1998 280 17 1472
42. Davies M. H., Da Silva R. C. M. A., Jones S. R., Weaver J. B., Elias E., Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid Gut 1995 37 4 580 584
43. Paternoster D. M., Fabris F., Pal G., Santarossa C., Bracciante R., Snijders D., Floreani A., Intra-hepatic cholestasis of pregnancy in hepatitis C virus infection Acta Obstetricia et Gynecologica Scandinavica 2002 81 2 99 103 (Pubitemid 34242364)
44. Saleh M. M., Abdo K. R., Intrahepatic cholestasis of pregnancy: review of the literature and evaluation of current evidence Journal of Women's Health 2007 16 6 833 841 (Pubitemid 47264832)
45. Brites D., Rodrigues C. M. P., Van-Zeller H., Brito A., Silva R., Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: portugal European Journal of Obstetrics Gynecology and Reproductive Biology 1998 80 1 31 38 (Pubitemid 29272016)
46. Soriano V., Puoti M., Garcia-Gasc P., Rockstroh J. K., Benhamou Y., Barreiro P., McGovern B., Antiretroviral drugs and liver injury AIDS 2008 22 1 1 13 (Pubitemid 350301936)