Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway

Journal of Chinese Integrative Medicine

Volumn 9, Issue 5, 2011, Pages 533-538

  Chu, Zhao Hui ^a,b   Liang, Xiao Hua ^a,b   Zhou, Xin Li ^a,b   Huang, Ruo Fan ^a,b   Zhan, Qiong ^a,b   Jiang, Jing Wei ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

1 phosphatidylinositol 3 kinase; Akt; Apoptosis; Cell proliferation; Deguelin; MCF 7 cell lineIn vitro

Indexed keywords

DEGUELIN; FLUORESCEIN ISOTHIOCYANATE; GLYCOGEN SYNTHASE KINASE 3BETA; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROPIDIUM IODIDE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION; WESTERN BLOTTING;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; ROTENONE; SIGNAL TRANSDUCTION;

EID: 79959360729     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20110511     Document Type: Article

References (13)

1. Chun KH, Kosmeder JW 2nd, Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst. 2003; 95(4): 291-302.
2. Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB. Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. J Immunol. 2006; 177(8): 5612-5622.
3. Bortul R, Tazzari PL, Billi AM, Tabellini G, Mantovani I, Cappellini A, Grafone T, Martinelli G, Conte R, Martelli AM. Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/ AKT pathway. Br J Haematol. 2005; 129 (5): 677-686.
4. Geeraerts B, Vanhoecke B, Vanden Berghe W, Philippe J, Offner F, Deforce D. Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro. Leukemia. 2007; 21(8): 1610-1618.
5. Yi T, Li H, Wang X, Wu Z. Enhancement radiosensitization of breast cancer cells by deguelin. Cancer Biother Radiopharm. 2008; 23(3): 355-362.
6. Jin Q, Feng L, Behrens C, Bekele BN, Wistuba II, Hong WK, Lee HY. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res. 2007; 67 (24): 11630-11639.
7. Tuoknaga E, Kimura Y, Mashino K, Oki E, Kataoka A, Ohno S, Morita M, Kakeji Y, Baba H, Maehara Y. Activation of PI3K/Akt signaling and hormone resistance in breast cancer. Breast Cancer. 2006; 13 (2): 137-144.
8. Li X, Lu Y, Liang K, Liu B, Fan Z. Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. Breast Cancer Res. 2005; 7(5): R589-R597.
9. Söderlund K, Pérez-Tenorio G, Stål O. Activation of the phosphatidylinositol 3-kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells. Int J Oncol. 2005; 26(1): 25-32.
10. Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. BiochemJ. 1999; 342 (Pt 2): 287-292.
11. Das S, Dixon JE, Cho W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A. 2003; 100(13): 7491-7496.
12. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995; 378(6559): 785-789.
13. Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998; 12(22): 3499-3511.