Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22362-22371

  Wu, Bill X ^a   Clarke, Christopher J ^a   Matmati, Nabil ^a   Montefusco, David ^a   Bartke, Nana ^a,b   Hannun, Yusuf A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Centre for Specialised Nutrition   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIONIC PHOSPHOLIPIDS; BINDING DOMAIN; BINDING STUDIES; BIOLOGICAL PROCESS; CATIONIC AMINO ACIDS; CERAMIDES; DELETION MUTANTS; ENZYMATIC ACTIVITIES; FIRST DOMAIN; HYDROPHOBIC SEGMENT; KEY ENZYMES; MUTAGENESIS EXPERIMENT; PHOSPHATIDIC ACIDS; PHOSPHATIDYLSERINE; SELECTIVE BINDING; SIGNALING PATHWAYS; SPHINGOLIPIDS; SPHINGOMYELINASE; STRUCTURAL REQUIREMENTS;

AMIDES; AMINO ACIDS; BIOCHEMISTRY; CATALYST ACTIVITY; CELL MEMBRANES; HYDROPHOBICITY; PHOSPHOLIPIDS;

ENZYME ACTIVITY;

ANIONIC PHOSPHOLIPID; ARGININE; PHOSPHATIDIC ACID; PHOSPHATIDYLSERINE; PHOSPHOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINASE 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; HYDROXYUREA; INTRACELLULAR SPACE; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SPHINGOMYELIN PHOSPHODIESTERASE; SUBSTRATE SPECIFICITY;

EID: 79959356986     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156471     Document Type: Article

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