Cilostazol, a type III phosphodiesterase inhibitor, reduces ischemia/reperfusion-induced spinal cord injury

Heart Surgery Forum

Volumn 14, Issue 3, 2011, Pages

  Sahin, Mehmet Ali ^a   Onan, Burak ^a   Guler, Adem ^a   Oztas, Emin ^a   Uysal, Bülent ^a   Arslan, Siddik ^b   Demirkilic, Ufuk ^a   Tatar, Harun ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CILOSTAZOL; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA BIFURCATION; AORTA CLAMPING; AORTA OCCLUSION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; HISTOPATHOLOGY; MALE; MENTAL HEALTH; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; RENAL ARTERY; REPERFUSION; REPERFUSION INJURY; SCORING SYSTEM; SHAM PROCEDURE; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA;

ANIMALS; MALE; PHOSPHODIESTERASE 3 INHIBITORS; RATS; RATS, WISTAR; REPERFUSION INJURY; SPINAL CORD INJURIES; TETRAZOLES; TREATMENT OUTCOME;

EID: 79959347420     PISSN: 10983511     EISSN: 15226662     Source Type: Journal    
DOI: 10.1532/HSF98.20101126     Document Type: Article

References (28)

1. Awad H, Ankeny DP, Guan Z, Wei P, McTigue DM, Popovich PG. 2010. A mouse model of ischemic spinal cord injury with delayed paralysis caused by aortic cross-clamping. Anesthesiology 113:880-91.
2. Bisleri G, Tisi G, Negri A, et al. 2005. The bicircuit system: innovative perfusional options for surgical treatment of the thoracic aorta. Ann Thorac Surg 79:678-80. (Pubitemid 40186581)
3. Boyle EJ, Pohlman TH, Cornejo CJ, Verrier ED. 1996. Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann Thorac Surg 62:1868-75.
4. Choi JM, Shin HK, Kim KY, Lee JH, Hong KW. 2002. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. J Pharmacol Exp Ther 300:787-93. (Pubitemid 34164980)
5. Coselli JS, LeMaire SA, Koksoy C, Schmittling ZC, Curling PE. 2002. Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair: results of a randomized clinical trial. J Vasc Surg 35:631-9.
6. Coselli JS, LeMaire SA, Poli de Figueiredo L, Kirby RP. 1997. Paraplegia after thoracoabdominal aortic aneurysm repair: Is dissection a risk factor? Ann Thorac Surg 63:28-36.
7. Dickens BF, Mak IT, Weglicki WB. 1988. Lysosomal lipolytic enzymes, lipid peroxidation, and injury. Mol Cell Biochem 82:119-23.
8. Dobashi K, Ghosh B, Orak JK, Singh I, Singh AK. 2000. Kidney ischemia-reperfusion: modulation of antioxidant defenses. Mol Cell Biochem 205:1-11. (Pubitemid 30216783)
9. Güler A, Sahin MA, Ucak A, et al. 2010. Protective effects of angiotensin II type-1 receptor blockade with olmesartan on spinal cord ischemia-reperfusion injury: an experimental study on rats. Ann Vasc Surg 24:801-8.
10. Honda F, Imai H, Ishikawa M, et al. 2006. Cilostazol attenuates gray and white matter damage in a rodent model of focal cerebral ischemia. Stroke 37:223-8. (Pubitemid 43732075)
11. Kimura Y, Tani T, Kanbe T, Watanabe K. 1985. Effect of cilostazol on platelet aggregation and experimental thrombosis. Arzneimmittelforschung 35:1144-9. (Pubitemid 15030828)
12. Kirsch JR, Helfaer MA, Lange DG, Traystman RJ. 1992. Evidence for free radical mechanisms of brain injury resulting from ischemia/reperfusion-induced events. J Neurotrauma 9:157-63.
13. Kohda N, Tani T, Nakayama S, et al. 1999. Effect of cilostazol, a phosphodiesterase III inhibitor, on experimental thrombosis in the porcine carotid artery. Thromb Res 96:261-8.
14. Lee JH, Kim YH, Lee YK, et al. 2004. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphate and tension homolog deleted from chromosome 10 phosphorylation in rats. J Pharmacol Exp Ther 308:896-903. (Pubitemid 38263963)
15. Lee JH, Lee YK, Ishikawa M, et al. 2003. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats - an MRI study. Brain Res 994:91-8. (Pubitemid 37452441)
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-75.
17. Manickavasagam S, Ye Y, Lin Y, et al. 2007. The cardioprotective effect of a statin and cilostazol combination: relationship to Akt and endothelial nitric oxide synthase activation. Cardiovasc Drugs Ther 21:321-30. (Pubitemid 47598922)
18. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-8. (Pubitemid 9194347)
19. Ota H, Eto M, Kano MR, et al. 2008. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 28:1634-9.
20. Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-69.
21. Sekiguchi M, Aoki Y, Konno S, Kikuchi S. 2008. The effects of cilostazol on nerve conduction velocity and blood flow: acute and chronic cauda equina compression in a canine model. Spine (Phila Pa 1976) 33:2605-11.
22. Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500.
23. Takei K, Tokuyama K, Kato M, Morikawa A. 1998. Role of cyclic adenosine monophosphate in reducing superoxide anion generation in guinea pig alveolar macrophages. Pharmacology 57:1-7. (Pubitemid 28288862)
24. Tanaka K, Gotoh F, Fukuuchi Y, et al. 1989. Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. Stroke 20:668-73. (Pubitemid 19139099)
25. Tarlov IM. 1972. Acute spinal cord compression in paralysis. J Neurosurg 36:10-20.
26. Ueno T, Furukawa K, Katayama Y, Suda H, Itoh T. 1994. Spinal cord protection: development of a paraplegia-preventive solution. Ann Thorac Surg 58:116-20. (Pubitemid 24243915)
27. Wada T, Yao H, Miyamoto T, Mukai S, Yamamura M. 2001. Prevention and detection of spinal cord injury during thoracic and thoracoabdominal aortic repairs. Ann Thorac Surg 72:80-5.
28. Watanabe T, Zhang N, Liu M, Tanaka R, Mizuno Y, Urabe T. 2006. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Stroke 37:1539-45. (Pubitemid 44305739)