Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study

Movement Disorders

Volumn 26, Issue 7, 2011, Pages 1297-1302

  Takado, Yuhei ^a   Igarashi, Hironaka ^a   Terajima, Kenshi ^a,b   Shimohata, Takayoshi ^a   Ozawa, Tetsutaro ^a   Okamoto, Kouichirou ^a   Nishizawa, Masatoyo ^a   Nakada, Tsutomu ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

Author keywords

Biomarker; Brainstem; MRS; MSA C; Myo inositol; UMSARS

Indexed keywords

CHOLINE; INOSITOL; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID;

ADULT; ARTICLE; BRAIN LEVEL; BRAIN STEM; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MALE; MEDULLA OBLONGATA; METABOLITE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PONS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SHY DRAGER SYNDROME;

AGED; ASPARTIC ACID; BIOLOGICAL MARKERS; CHOLINE; CREATININE; DIPEPTIDES; FEASIBILITY STUDIES; FEMALE; GLUTAMIC ACID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MEDULLA OBLONGATA; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; PONS; PROTONS; SEVERITY OF ILLNESS INDEX;

EID: 79959343647     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23550     Document Type: Article

References (30)

1. Gilman S, Low PA, Quinn N, et al. Consensus statement on the diagnosis of multiple system atrophy. J Neurol Sci 1999; 163: 94-98.
2. Wenning GK, Tison F, Seppi K, et al. Development and validation of the unified multiple system atrophy rating scale (UMSARS). Mov Disord 2004; 19: 1391-1402.
3. Wenning GK, Stefanova N. Recent developments in multiple system atrophy. J Neurol 2009; 256: 1791-1808.
4. Ozawa T, Paviour D, Quinn NP, et al. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 2004; 127(Part 12): 2657-2671.
5. Watanabe H, Fukatsu H, Katsuno M, et al. Multiple regional 1H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker. J Neurol Neurosurg Psychiatry 2004; 75: 103-109.
6. Mascalchi M, Cosottini M, Lolli F, et al. Proton MR spectroscopy of the cerebellum and pons in patients with degenerative ataxia. Radiology 2002; 223: 371-378.
7. Terakawa H, Abe K, Watanabe Y, et al. Proton magnetic resonance spectroscopy (1H MRS) in patients with sporadic cerebellar degeneration. J Neuroimaging 1999; 9: 72-77.
8. Davie CA, Wenning GK, Barker GJ, et al. Differentiation of multiple system atrophy from idiopathic Parkinson's disease using proton magnetic resonance spectroscopy. Ann Neurol 1995; 37: 204-210.
9. Ozawa T, Tada M, Kakita A, et al. The phenotype spectrum of Japanese multiple system atrophy. J Neurol Neurosurg Psychiatry 2010; 81: 1253-1255.
10. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 2008; 71: 670-676.
11. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001; 14: 260-264.
12. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993; 30: 672-679.
13. Ozawa T. Morphological substrate of autonomic failure and neurohormonal dysfunction in multiple system atrophy: impact on determining phenotype spectrum. Acta Neuropathol 2007; 114: 201-211.
14. Benarroch EE. Brainstem respiratory chemosensitivity: new insights and clinical implications. Neurology 2007; 68: 2140-2143.
15. Mascalchi M, Brugnoli R, Guerrini L, et al. Single-voxel long TE 1H-MR spectroscopy of the normal brainstem and cerebellum. J Magn Reson Imaging 2002; 16: 532-537.
16. Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993; 15: 289-298.
17. Hattingen E, Raab P, Franz K, Zanella FE, Lanfermann H, Pilatus U. Myo-inositol: a marker of reactive astrogliosis in glial tumors? NMR Biomed 2008; 21: 233-241.
18. Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol 2010; 119: 7-35.
19. Kantarci K, Jack CR, Jr, Xu YC, et al. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: a 1H MRS study. Neurology 2000; 55: 210-217.
20. Srinivasan R, Vigneron D, Sailasuta N, Hurd R, Nelson S. A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain. Magn Reson Imaging 2004; 22: 523-528.
21. Boesch SM, Wolf C, Seppi K, Felber S, Wenning GK, Schocke M. Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging. J Magn Reson Imaging 2007; 25: 564-569.
22. Li X, Lu Y, Pirzkall A, McKnight T, Nelson SJ. Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients. J Magn Reson Imaging 2002; 16: 229-237.
23. Oz G, Hutter D, Tkac I, et al. Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord 2010: 25: 1253-1261.
24. Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13: 981-989.
25. De Graaf R. In vivo NMR spectroscopy: principles and techniques, Second ed. Chichester: Wiley; 2007. 55 p.
26. Griffin JL, Mann CJ, Scott J, Shoulders CC, Nicholson JK. Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes. FEBS Lett 2001; 509: 263-266.
27. Kreis R, Ross BD, Farrow NA, Ackerman Z. Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy. Radiology 1992; 182: 19-27.
28. Gomez-Anson B, Alegret M, Munoz E, Sainz A, Monte GC, Tolosa E. Decreased frontal choline and neuropsychological performance in preclinical Huntington disease. Neurology 2007; 68: 906-910.
29. Debray FG, Boulanger Y, Khiat A, et al. Reduced brain choline in homocystinuria due to remethylation defects. Neurology 2008; 71: 44-49.
30. Wenning GK, Stefanova N, Jellinger KA, Poewe W, Schlossmacher MG. Multiple system atrophy: a primary oligodendrogliopathy. Ann Neurol 2008; 64: 239-246.