메뉴 건너뛰기




Volumn 37, Issue 7, 2011, Pages 495-504

Evolving options for the treatment of metastatic breast cancer: Progression-free survival as an endpoint

Author keywords

Metastatic breast cancer; Overall survival; Progression free survival; Treatment options

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; ERIBULIN; FLUOROURACIL; GEMCITABINE; INIPARIB; IXABEPILONE; LAPATINIB; NAVELBINE; PACLITAXEL; PLACEBO; TRASTUZUMAB;

EID: 79959288115     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2011.01.002     Document Type: Review
Times cited : (17)

References (48)
  • 1
    • 80052373177 scopus 로고    scopus 로고
    • Note
    • Food and Drug Administration. Guidance for Industry. Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics. Rockville: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), May 2007.
  • 2
    • 0037674049 scopus 로고    scopus 로고
    • Overall survival is not a realistic end point for clinical trials of new drugs in advanced solid tumors: a critical assessment based on recently reported phase III trials in colorectal and breast cancer
    • Di Leo A., Bleiberg H., Buyse M. Overall survival is not a realistic end point for clinical trials of new drugs in advanced solid tumors: a critical assessment based on recently reported phase III trials in colorectal and breast cancer. J Clin Oncol 2003, 21(10):2045-2047.
    • (2003) J Clin Oncol , vol.21 , Issue.10 , pp. 2045-2047
    • Di Leo, A.1    Bleiberg, H.2    Buyse, M.3
  • 3
    • 0037441856 scopus 로고    scopus 로고
    • Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (E1193)
    • Sledge G.W., Neuberg D., Bernardo P., et al. Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (E1193). J Clin Oncol 2003, 21:588-592.
    • (2003) J Clin Oncol , vol.21 , pp. 588-592
    • Sledge, G.W.1    Neuberg, D.2    Bernardo, P.3
  • 4
    • 78649973762 scopus 로고    scopus 로고
    • Final efficacy and safety results of a randomized phase II study of the PARP inhibitor iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC)
    • [abstr. LBA11]
    • O'Shaughnessy J., Osborne C., Pippen J., et al. Final efficacy and safety results of a randomized phase II study of the PARP inhibitor iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC). Ann Oncol 2010, 21(s8):viii5. [abstr. LBA11].
    • (2010) Ann Oncol , vol.21 , Issue.S8
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 5
    • 67649990278 scopus 로고    scopus 로고
    • Issues in using progression-free survival when evaluating oncology products
    • Fleming T.R., Rothmann M.D., Lu H.L. Issues in using progression-free survival when evaluating oncology products. J Clin Oncol 2009, 27(17):2874-2880.
    • (2009) J Clin Oncol , vol.27 , Issue.17 , pp. 2874-2880
    • Fleming, T.R.1    Rothmann, M.D.2    Lu, H.L.3
  • 6
    • 77949321968 scopus 로고    scopus 로고
    • Progression-free survival as surrogate and as true end point: insights from the breast and colorectal cancer literature
    • Saad E.D., Katz A., Hoff P.M., Buyse M. Progression-free survival as surrogate and as true end point: insights from the breast and colorectal cancer literature. Ann Oncol 2010, 21(1):7-12.
    • (2010) Ann Oncol , vol.21 , Issue.1 , pp. 7-12
    • Saad, E.D.1    Katz, A.2    Hoff, P.M.3    Buyse, M.4
  • 7
    • 77954629858 scopus 로고    scopus 로고
    • The role of the US food and drug administration review process: clinical trial endpoints in oncology
    • Mckee A.E., Farrell A.T., Pazdur R., Woodcock J. The role of the US food and drug administration review process: clinical trial endpoints in oncology. The Oncologist 2010, 15(s10):13-18.
    • (2010) The Oncologist , vol.15 , Issue.10 , pp. 13-18
    • Mckee, A.E.1    Farrell, A.T.2    Pazdur, R.3    Woodcock, J.4
  • 8
    • 24944507764 scopus 로고    scopus 로고
    • Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer
    • Jones S.E., Erban J., Overmoyer B., Budd G.T., et al. Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J Clin Oncol 2005, 23(24):5542-5551.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5542-5551
    • Jones, S.E.1    Erban, J.2    Overmoyer, B.3    Budd, G.T.4
  • 9
    • 27244438750 scopus 로고    scopus 로고
    • Phase II to III study comparing doxorubicin and docetaxel with fluorouracil, doxorubicin, and cyclophosphamide as first-line chemotherapy in patients with metastatic breast cancer: results of a Dutch Community Setting Trial for the Clinical Trial Group of the Comprehensive Cancer Centre
    • Bontenbal M., Creemers G.J., Braun H.J., et al. Phase II to III study comparing doxorubicin and docetaxel with fluorouracil, doxorubicin, and cyclophosphamide as first-line chemotherapy in patients with metastatic breast cancer: results of a Dutch Community Setting Trial for the Clinical Trial Group of the Comprehensive Cancer Centre. J Clin Oncol 2005, 23(28):7081-7088.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7081-7088
    • Bontenbal, M.1    Creemers, G.J.2    Braun, H.J.3
  • 10
    • 0035868906 scopus 로고    scopus 로고
    • Doxorubicin and paclitaxel versus fluorouracil, doxorubicin, and cyclophosphamide as first-line therapy for women with metastatic breast cancer: final results of a randomized phase III multicenter trial
    • Jassem J., Pienkowski T., Pluzanska A., et al. Doxorubicin and paclitaxel versus fluorouracil, doxorubicin, and cyclophosphamide as first-line therapy for women with metastatic breast cancer: final results of a randomized phase III multicenter trial. J Clin Oncol 2001, 19(6):1707-1715.
    • (2001) J Clin Oncol , vol.19 , Issue.6 , pp. 1707-1715
    • Jassem, J.1    Pienkowski, T.2    Pluzanska, A.3
  • 11
    • 70249129810 scopus 로고    scopus 로고
    • Doxorubicin and paclitaxel versus fluorouracil, doxorubicin and cyclophosphamide as first-Line therapy for women with advanced breast cancer: long-term analysis of the previously published trial
    • Jassem J., Pienkowski T., Pluzanska A., et al. Doxorubicin and paclitaxel versus fluorouracil, doxorubicin and cyclophosphamide as first-Line therapy for women with advanced breast cancer: long-term analysis of the previously published trial. Onkologie 2009, 32(8-9):468-472.
    • (2009) Onkologie , vol.32 , Issue.8-9 , pp. 468-472
    • Jassem, J.1    Pienkowski, T.2    Pluzanska, A.3
  • 12
    • 0037096755 scopus 로고    scopus 로고
    • Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results
    • O'Shaughnessy J., Miles D., Vukelja S., et al. Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results. J Clin Oncol 2002, 20(12):2812-2823.
    • (2002) J Clin Oncol , vol.20 , Issue.12 , pp. 2812-2823
    • O'Shaughnessy, J.1    Miles, D.2    Vukelja, S.3
  • 13
    • 50549096593 scopus 로고    scopus 로고
    • Gemcitabine plus Paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
    • Albain K.S., Nag S.M., Calderillo-Ruiz G., et al. Gemcitabine plus Paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment. J Clin Oncol 2008, 26(24):3950-3957.
    • (2008) J Clin Oncol , vol.26 , Issue.24 , pp. 3950-3957
    • Albain, K.S.1    Nag, S.M.2    Calderillo-Ruiz, G.3
  • 14
    • 67650674658 scopus 로고    scopus 로고
    • For the Early Breast Cancer Trialists' Collaborative Group University of Oxford. The worldwide overview: new results for systemic adjuvant therapies
    • [abstr. P-1, plenary lecture]
    • Peto R. For the Early Breast Cancer Trialists' Collaborative Group University of Oxford. The worldwide overview: new results for systemic adjuvant therapies. Breast Cancer Res Treat 2007, 106(Suppl. 1). [abstr. P-1, plenary lecture].
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • Peto, R.1
  • 15
    • 0037445247 scopus 로고    scopus 로고
    • Docetaxel and doxorubicin compared with doxorubicin and cyclophosphamide as first-line chemotherapy for metastatic breast cancer: results of a randomized, multicenter, phase III trial
    • Nabholtz J.M., Falkson C., Campos D., et al. Docetaxel and doxorubicin compared with doxorubicin and cyclophosphamide as first-line chemotherapy for metastatic breast cancer: results of a randomized, multicenter, phase III trial. J Clin Oncol 2003, 21(6):968-975.
    • (2003) J Clin Oncol , vol.21 , Issue.6 , pp. 968-975
    • Nabholtz, J.M.1    Falkson, C.2    Campos, D.3
  • 16
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar W.J., Tjulandin S., Davidson N., et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005, 23(31):7794-7803.
    • (2005) J Clin Oncol , vol.23 , Issue.31 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 17
    • 76749156249 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin plus docetaxel significantly improves time to progression without additive cardiotoxicity compared with docetaxel monotherapy in patients with advanced breast cancer previously treated with neoadjuvant-adjuvant anthracycline therapy: results from a randomized phase III study
    • Sparano J.A., Makhson A.N., Semiglazov V.F., et al. Pegylated liposomal doxorubicin plus docetaxel significantly improves time to progression without additive cardiotoxicity compared with docetaxel monotherapy in patients with advanced breast cancer previously treated with neoadjuvant-adjuvant anthracycline therapy: results from a randomized phase III study. J Clin Oncol 2009, 27(27):4522-4529.
    • (2009) J Clin Oncol , vol.27 , Issue.27 , pp. 4522-4529
    • Sparano, J.A.1    Makhson, A.N.2    Semiglazov, V.F.3
  • 18
    • 33847138943 scopus 로고    scopus 로고
    • Gemcitabine plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: final results of the phase III Spanish Breast Cancer Research Group (GEICAM) trial
    • Martin M., Ruiz A., Munoz M., et al. Gemcitabine plus vinorelbine versus vinorelbine monotherapy in patients with metastatic breast cancer previously treated with anthracyclines and taxanes: final results of the phase III Spanish Breast Cancer Research Group (GEICAM) trial. Lancet Oncol 2007, 8(3):219-225.
    • (2007) Lancet Oncol , vol.8 , Issue.3 , pp. 219-225
    • Martin, M.1    Ruiz, A.2    Munoz, M.3
  • 19
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • Thomas E.S., Gomez H.L., Li R.K., et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 2007, 25(33):5210-5217.
    • (2007) J Clin Oncol , vol.25 , Issue.33 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3
  • 20
    • 77955448465 scopus 로고    scopus 로고
    • Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes
    • Hortobagyi G.N., Gomez H.L., Li R.K., et al. Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes. Breast Cancer Res Treat 2010, 122:409-418.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 409-418
    • Hortobagyi, G.N.1    Gomez, H.L.2    Li, R.K.3
  • 21
    • 77954752064 scopus 로고    scopus 로고
    • Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Sparano J.A., Vrdoljak E., Rixe O., et al. Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2010, 28(20):3256-3263.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3256-3263
    • Sparano, J.A.1    Vrdoljak, E.2    Rixe, O.3
  • 22
    • 77955893812 scopus 로고    scopus 로고
    • A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline, a taxane
    • [abstr CRA1004^]
    • Twelves C., Loesch D., Blum J.L., et al. A phase III study (EMBRACE) of eribulin mesylate versus treatment of physician's choice in patients with locally recurrent or metastatic breast cancer previously treated with an anthracycline, a taxane. J Clin Oncol 2010, 28:18s. [abstr CRA1004^].
    • (2010) J Clin Oncol , vol.28
    • Twelves, C.1    Loesch, D.2    Blum, J.L.3
  • 23
    • 15544391142 scopus 로고    scopus 로고
    • Angiogenesis of breast cancer
    • Schneider B.P., Miller K.D. Angiogenesis of breast cancer. J Clin Oncol 2005, 23(8):1782-1790.
    • (2005) J Clin Oncol , vol.23 , Issue.8 , pp. 1782-1790
    • Schneider, B.P.1    Miller, K.D.2
  • 24
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller K.D., Chap L.I., Holmes F.A., et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005, 23(4):792-799.
    • (2005) J Clin Oncol , vol.23 , Issue.4 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 25
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357(26):2666-2676.
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 26
    • 77955883504 scopus 로고    scopus 로고
    • A meta-analysis of overall survival data from three randomized trials of bevacizumab (BV) and first-line chemotherapy as treatment for patients with metastatic breast cancer (MBC)
    • [abstr. 1005]
    • O'Shaughnessy J., Miles D., Grey R.J., et al. A meta-analysis of overall survival data from three randomized trials of bevacizumab (BV) and first-line chemotherapy as treatment for patients with metastatic breast cancer (MBC). J Clin Oncol 2010, 28(15s):115s. [abstr. 1005].
    • (2010) J Clin Oncol , vol.28 , Issue.15
    • O'Shaughnessy, J.1    Miles, D.2    Grey, R.J.3
  • 27
    • 54249120945 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO
    • [abstr. LBA1011^]
    • Miles D.W., Chan A., Romieu G., et al. Randomized, double-blind, placebo-controlled, phase III study of bevacizumab with docetaxel or docetaxel with placebo as first-line therapy for patients with locally recurrent or metastatic breast cancer (mBC): AVADO. J Clin Oncol 2008, 26(15S):43s. [abstr. LBA1011^].
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Miles, D.W.1    Chan, A.2    Romieu, G.3
  • 28
    • 76949092091 scopus 로고    scopus 로고
    • Final overall survival (OS) results from the randomised, double-blind, placebo-controlled, phase III AVADO study of bevacizumab (BV) plus docetaxel (D) compared with placebo (PL) plus D for the first-line treatment of locally recurrent (LR) or metastatic breast cancer (mBC)
    • [abstr. 41]
    • Miles D.W., Chan A., Romieu G., et al. Final overall survival (OS) results from the randomised, double-blind, placebo-controlled, phase III AVADO study of bevacizumab (BV) plus docetaxel (D) compared with placebo (PL) plus D for the first-line treatment of locally recurrent (LR) or metastatic breast cancer (mBC). Cancer Res 2009, 69(24 Suppl. 3). [abstr. 41].
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL. 3
    • Miles, D.W.1    Chan, A.2    Romieu, G.3
  • 29
    • 70249097518 scopus 로고    scopus 로고
    • RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC)
    • [abstr. 1005]
    • Robert N.J., Dieras V., Glaspy J., et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab (B) for first-line treatment of HER2-negative locally recurrent or metastatic breast cancer (MBC). J Clin Oncol 2009, 27(15S):42s. [abstr. 1005].
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 30
    • 76949108277 scopus 로고    scopus 로고
    • RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of HER2-negative metastatic breast cancer
    • [abstr. 42]
    • Brufsky A., Bondarenko I.N., Smirnov V., et al. RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of HER2-negative metastatic breast cancer. Cancer Res 2009, 69(24 Suppl. 3):345. [abstr. 42].
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL. 3 , pp. 345
    • Brufsky, A.1    Bondarenko, I.N.2    Smirnov, V.3
  • 31
    • 77957329500 scopus 로고    scopus 로고
    • Progression-free survival (PFS) in patient subgroups in RIBBON-2, a phase III trial of chemotherapy (chemo) plus or minus bevacizumab (BV) for second-line treatment of HER2-negative, locally recurrent or metastatic breast cancer (MBC)
    • [abstr. 1021]
    • Brufsky A., Rivera R.R., Hurvitz S.A., et al. Progression-free survival (PFS) in patient subgroups in RIBBON-2, a phase III trial of chemotherapy (chemo) plus or minus bevacizumab (BV) for second-line treatment of HER2-negative, locally recurrent or metastatic breast cancer (MBC). J Clin Oncol 2010, 28(15S):119s. [abstr. 1021].
    • (2010) J Clin Oncol , vol.28 , Issue.15 S
    • Brufsky, A.1    Rivera, R.R.2    Hurvitz, S.A.3
  • 32
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344(11):783-792.
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 33
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group
    • Marty M., Cognetti F., Maraninchi D., et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005, 23(19):4265-4274.
    • (2005) J Clin Oncol , vol.23 , Issue.19 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 34
    • 54049149104 scopus 로고    scopus 로고
    • Capecitabine vs. capecitabine+trastuzumab in patients with HER-2 positive metastatic breast cancer progressing during trastuzumab treatment - the TBP phase III study (GBG 26/BIG 3-05)
    • [abstr. 1330]
    • Von Minckwitz G., Zielinski C., Maarteense E., et al. Capecitabine vs. capecitabine+trastuzumab in patients with HER-2 positive metastatic breast cancer progressing during trastuzumab treatment - the TBP phase III study (GBG 26/BIG 3-05). Ann Oncol 2008, 19(Suppl. 8):viii63. [abstr. 1330].
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 8
    • Von Minckwitz, G.1    Zielinski, C.2    Maarteense, E.3
  • 35
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses
    • Cameron D., Casey M., Press M., et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008, 112(3):533-543.
    • (2008) Breast Cancer Res Treat , vol.112 , Issue.3 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 36
    • 54249153119 scopus 로고    scopus 로고
    • A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy
    • [abstr. 1015]
    • O'Shaughnessy J., Blackwell K.L., Burstein H., et al. A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. J Clin Oncol 2008, 26(15S):44s. [abstr. 1015].
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • O'Shaughnessy, J.1    Blackwell, K.L.2    Burstein, H.3
  • 37
    • 77949721591 scopus 로고    scopus 로고
    • Updated survival analysis of a randomized study of Lapatinib alone or in combination with Trastuzumab in women with HER2-positive metastatic breast cancer progressing on Trastuzumab therapy
    • [abstr. 61]
    • Blackwell K.L., Burstein H.J., Sledge G.W., et al. Updated survival analysis of a randomized study of Lapatinib alone or in combination with Trastuzumab in women with HER2-positive metastatic breast cancer progressing on Trastuzumab therapy. Cancer Res 2009, 69(24 Suppl. 3). [abstr. 61].
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL. 3
    • Blackwell, K.L.1    Burstein, H.J.2    Sledge, G.W.3
  • 38
    • 77953342817 scopus 로고    scopus 로고
    • HER2/neu expression correlates with vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer
    • Schoppmann S.F., Tamandl D., Roberts L., et al. HER2/neu expression correlates with vascular endothelial growth factor-C and lymphangiogenesis in lymph node-positive breast cancer. Ann Oncol 2010, 21(5):955-960.
    • (2010) Ann Oncol , vol.21 , Issue.5 , pp. 955-960
    • Schoppmann, S.F.1    Tamandl, D.2    Roberts, L.3
  • 39
    • 12144291334 scopus 로고    scopus 로고
    • Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
    • Konecny G.E., Meng Y.G., Untch M., et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004, 10(5):1706-1716.
    • (2004) Clin Cancer Res , vol.10 , Issue.5 , pp. 1706-1716
    • Konecny, G.E.1    Meng, Y.G.2    Untch, M.3
  • 40
    • 21044443432 scopus 로고    scopus 로고
    • Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF)
    • [abstr. 3039]
    • Pegram M.D., Yeon C., Ku N.C., et al. Phase I combined biological therapy of breast cancer using two humanized monoclonal antibodies directed against HER2 proto-oncogene and vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2004, 88(Suppl. 1):S124. [abstr. 3039].
    • (2004) Breast Cancer Res Treat , vol.88 , Issue.SUPPL. 1
    • Pegram, M.D.1    Yeon, C.2    Ku, N.C.3
  • 41
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • Eccles S.A. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia 2001, 6(4):393-406.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , Issue.4 , pp. 393-406
    • Eccles, S.A.1
  • 42
    • 66049084743 scopus 로고    scopus 로고
    • Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes
    • Gaymes T.J., Shall S., MacPherson L.J., et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 2009, 94(5):638-646.
    • (2009) Haematologica , vol.94 , Issue.5 , pp. 638-646
    • Gaymes, T.J.1    Shall, S.2    MacPherson, L.J.3
  • 43
    • 76149107145 scopus 로고    scopus 로고
    • Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer
    • Comen E.A., Robson M. Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. Oncology (Williston Park) 2010, 24(1):55-62.
    • (2010) Oncology (Williston Park) , vol.24 , Issue.1 , pp. 55-62
    • Comen, E.A.1    Robson, M.2
  • 44
    • 77149171459 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer
    • Comen E.A., Robson M. Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. Cancer J 2010, 16(1):48-52.
    • (2010) Cancer J , vol.16 , Issue.1 , pp. 48-52
    • Comen, E.A.1    Robson, M.2
  • 45
    • 80052352370 scopus 로고    scopus 로고
    • Post-progression survival (PPS) and overall survival (OS) according to treatment type in contemporary phase III trials in advanced breast cancer (ABC)
    • [abstr. 5116]
    • Saad E.D., Katz A., Machado K.K., Buyse M. Post-progression survival (PPS) and overall survival (OS) according to treatment type in contemporary phase III trials in advanced breast cancer (ABC). Cancer Res 2009, 69(24 Suppl. 3). [abstr. 5116].
    • (2009) Cancer Res , vol.69 , Issue.24 SUPPL. 3
    • Saad, E.D.1    Katz, A.2    Machado, K.K.3    Buyse, M.4
  • 46
    • 42949145995 scopus 로고    scopus 로고
    • Evaluation of tumor response, disease control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast cancer
    • Burzykowski T., Buyse M., Piccart-Gebhart M.J., et al. Evaluation of tumor response, disease control, progression-free survival, and time to progression as potential surrogate end points in metastatic breast cancer. J Clin Oncol 2008, 26(12):1987-1992.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 1987-1992
    • Burzykowski, T.1    Buyse, M.2    Piccart-Gebhart, M.J.3
  • 47
    • 55949094052 scopus 로고    scopus 로고
    • Relationship between effects on time-to-disease progression and overall survival in studies of metastatic breast cancer
    • Sherrill B., Amonkar M., Wu Y., et al. Relationship between effects on time-to-disease progression and overall survival in studies of metastatic breast cancer. Br J Cancer 2008, 99(10):1572-1578.
    • (2008) Br J Cancer , vol.99 , Issue.10 , pp. 1572-1578
    • Sherrill, B.1    Amonkar, M.2    Wu, Y.3
  • 48
    • 33747844588 scopus 로고    scopus 로고
    • Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis
    • Johnson K.R., Ringland C., Stokes B.J., et al. Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis. Lancet Oncol 2006, 7:741-746.
    • (2006) Lancet Oncol , vol.7 , pp. 741-746
    • Johnson, K.R.1    Ringland, C.2    Stokes, B.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.