Regulation of Rac1 and Cdc42 activation in thrombin- and collagen-stimulated CHRF-288-11 cells

Molecular and Cellular Biochemistry

Volumn 353, Issue 1-2, 2011, Pages 73-79

  Xu, Bing ^a   Bhullar, Rajinder P ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Calmodulin; Cdc42; Collagen; GTPases; Rac1; Thrombin

Indexed keywords

CALMODULIN INHIBITOR; COLLAGEN; N (6 AMINOHEXYL) 1 NAPHTHALENESULFONAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; PROTEIN CDC42; RAC1 PROTEIN; THROMBIN;

ARTICLE; CELL LINE; CHRF 288 11; CONTROLLED STUDY; GENE OVEREXPRESSION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; TRANSIENT TRANSFECTION;

BLOTTING, WESTERN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CALMODULIN; CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; COLLAGEN; ENZYME ACTIVATION; HEMOSTATICS; HUMANS; MEGAKARYOCYTES; RAC1 GTP-BINDING PROTEIN; SULFONAMIDES; THROMBIN; TIME FACTORS; TRANSFECTION;

EID: 79959253008     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0776-7     Document Type: Article

References (26)

1. Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21:247-269 (Pubitemid 41740635)
2. Ridley AJ (2006) Rho proteins and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 16:522-529
3. Bos JL, Rehmann H, Wittinghofer A (2007) A GEFs and GAPs: critical elements in the control of small G proteins. Cell 129:865-877 (Pubitemid 46802708)
4. Soulet CS, Gendreau S, Missy K, Benard V, Plantavid M, Payrastre B (2001) Characterisation of Rac activation in thrombinand collagen-stimulated human blood platelets. FEBS Lett 507:253-258 (Pubitemid 33030245)
5. Pelletier S, Duhamel F, Coulombe P, Popoff MR, Meloche S (2003) Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol 23:1316-1333 (Pubitemid 36177040)
6. Kurokawa K, Itoh RE, Yoshizaki H, Nakamura YO, Matsuda M (2004) Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. Mol Biol Cell 15:1003-1010 (Pubitemid 38316211)
7. Itoh RE, Kiyokawa E, Aoki K, Nishioka T, Akiyama T, Matsuda M (2008) Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF. J Cell Sci 121:2635-2642
8. Grill B, Schrader JW (2002) Activation of Rac1, Rac2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen. Blood 100:3183-3192
9. Hou Y, Ye RD, Browning DD (2004) Activation of the small GTPase Rac1 by cGMP-dependent protein kinase. Cell Signal 16:1061-1069 (Pubitemid 38798056)
10. Barber SC, Mellor H, Gampel A, Scolding NJ (2004) S1P and LPA trigger Schwann cell actin changes and migration. Eur J Neurosci 19:3142-3150 (Pubitemid 38859531)
11. Akbar H, Kim J, Funk K, Cancelas JA, Shang X, Chen L, Johnson JF, Williams DA, Zheng Y (2007) Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. J Thromb Haemost 5:1747-1755 (Pubitemid 47091420)
12. Elsaraj SM, Bhullar RP (2008) Regulation of platelet Rac1 and Cdc42 activation through interaction with calmodulin. Biochim Biophys Acta 1783:770-778
13. Vittet D, Mathieu MN, Launay JM, Chevillard C (1992) Platelet receptor expression on three human megakaryoblast like cell lines. Exp Hematol 20:1129-1134
14. Kaplan KL, Broekmam MJ, Chemoff A, Lesznik GR, Drillings M (1979) Platelet alpha-granule proteins: studies on release and subcellular localization. Blood 53:604-618 (Pubitemid 9154938)
15. Holt JC, Niewiarowski S (1985) Biochemistry of alpha granule proteins. Semin Hematol 22:151-163
16. Fugman DA, Witte DP, Jones CL, Aronow BJ, Lieberman MA (1990) In vitro establishment and characterization of a human megakaryoblastic cell line. Blood 75:1252-1261
17. Dorn GW, Davis MG (1992) Differential megakaryocytic desensitization to platelet agonists. Am J Physiol 263:c864-c872
18. Dash D, Aepfelbacher M, Siess W (1995) Integrin αIIbβ3- mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets. J Biol Chem 270:17321-17326
19. Lian P, Crossley L, Zhan Q, Huang RY, Coffer P, Toker A, Robinson D, Badwey JA (2001) Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophils. J Immunol 166:2643-2650 (Pubitemid 32173503)
20. Manser E, Leung T, Salihuddin H, Zaho ZS, Lim L (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-46 (Pubitemid 24038530)
21. Bagrodia S, Cerione RA (1999) PAK to the future. Trends Cell Biol 9:350-355 (Pubitemid 29447715)
22. Price LS, Langeslag M, Klooster JPT, Hordijk PL, Jalink K, Collard JG (2003) Calcium signaling regulates translocation and activation of Rac. J Biol Chem 278:39413-39421 (Pubitemid 37248496)
23. Yeh YC, Wang CZ, Tang MJ (2009) Discoidin receptor 1 activation suppresses α2β1 integrin-dependent cell spreading through inhibition of cdc42 activity. J Cell Physiol 218:146-156
24. Scita G, Tenca P, Frittoli EA, Tocchetti A, Innocenti M, Giardina G, Di Fiore PP (2000) Signaling from Ras to Rac and beyond: not just a matter of GEFs. EMBO J 19:2393-2398 (Pubitemid 30323529)
25. Quatela SE, Philips MR (2006) Ras signaling on the Golgi. Curr Opin Cell Bio 18:162-167 (Pubitemid 43375884)
26. 2+/calmodulin stimulates GTP binding to the ras-related protein ral-A. J Biol Chem 274:14525-14528