Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease

European Journal of Human Genetics

Volumn 19, Issue 7, 2011, Pages 796-800

  Johansson, Åsa ^a,b,c   Curran, Joanne E ^b   Johnson, Matthew P ^b   Freed, Katy A ^b   Fenstad, Mona H ^a,d   Bjørge, Line ^e   Eide, Irina P ^f   Carless, Melanie A ^b   Rainwater, David L ^b   Goring, Harald H H ^b   Austgulen, Rigmor ^a   Moses, Eric K ^b   Blangero, John ^b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^f Central Norway Regional Health Authority ^*  (Norway)

Author keywords

hyperlipidemia; preeclampsia; transcription profiling; triglyceride

Indexed keywords

ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 2; BILE ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID BLOOD LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HYPERTENSION; LYMPHOCYTE; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEINURIA; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ACYL-COA OXIDASE; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LEUKOCYTES; LIPID METABOLISM; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS; TRIGLYCERIDES;

EID: 79959238545     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2011.19     Document Type: Article

References (40)

1. Roberts JM, Pearson G, Cutler J, Lindheimer M: Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension 2003; 41: 437-445. (Pubitemid 36314613)
2. Goldenberg RL, Rouse DJ: Prevention of premature birth. N Engl J Med 1998; 339: 313-320. (Pubitemid 28366421)
3. Craici I, Wagner S, Garovic VD: Preeclampsia and future cardiovascular risk: formal risk factor or failed stress test? Ther Adv Cardiovasc Dis 2008; 2: 249-259.
4. Magnussen EB, Vatten LJ, Lund-Nilsen TI, Salvesen KA, Davey Smith G, Romundstad PR: Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. BMJ 2007; 335: 978.
5. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ: Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 1997; 89: 403-408. (Pubitemid 27086096)
6. Irgens HU, Reisaeter L, Irgens LM, Lie RT: Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ 2001; 323: 1213-1217.
7. Funai EF, Friedlander Y, Paltiel O et al: Long-term mortality after preeclampsia. Epidemiology 2005; 16: 206-215. (Pubitemid 40314413)
8. Salonen Ros H, Lichtenstein P, Lipworth L, Cnattingius S: Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet 2000; 91: 256-260. (Pubitemid 30191247)
9. Goring HH, Curran JE, Johnson MP et al: Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 2007; 39: 1208-1216. (Pubitemid 47482685)
10. Enquobahrie DA, Meller M, Rice K, Psaty BM, Siscovick DS, Williams MA: Differential placental gene expression in preeclampsia. Am J Obstet Gynecol 2008; 199: 566-568.
11. Løset M, Mundal SB, Johnson MP et al: A transcriptional profile of the decidua in preeclampsia. Am J Obstet Gynecol 2011; 204: 84-86.
12. Winn VD, Gormley M, Paquet AC et al: Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulinlike lectin-6 and pappalysin-2. Endocrinology 2009; 150: 452-462.
13. Gifford RW, August PA, Cunningham G et al: Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
14. Fenstad MH, Johnson MP, Loset M et al: STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women. Mol Hum Reprod 2010; 16: 960-968.
15. MacCluer JW, Stern MP, Almasy L et al: Genetics of atherosclerosis risk factors in Mexican Americans. Nutr Rev 1999; 57: S59-S65. (Pubitemid 29301214)
16. Mitchell BD, Kammerer CM, Blangero J et al: Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation 1996; 94: 2159-2170. (Pubitemid 26360509)
17. Hochberg Y, Benjamini Y: More powerful procedures for multiple significance testing. Stat Med 1990; 9: 811-818. (Pubitemid 20343989)
18. Strimmer K: A unified approach to false discovery rate estimation. BMC Bioinform 2008; 9: 303.
19. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198-1211. (Pubitemid 28199022)
20. Criqui MH, Heiss G, Cohn R et al: Plasma triglyceride level and mortality from coronary heart disease. N Engl J Med 1993; 328: 1220-1225. (Pubitemid 23115700)
21. Chappell LC, Seed PT, Briley A et al: A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol 2002; 187: 127-136. (Pubitemid 34800311)
22. Gratacos E, Casals E, Sanllehy C, Cararach V, Alonso PL, Fortuny A: Variation in lipid levels during pregnancy in women with different types of hypertension. Acta Obstet Gynecol Scand 1996; 75: 896-901. (Pubitemid 27007863)
23. Hubel CA, McLaughlin MK, Evans RW, Hauth BA, Sims CJ, Roberts JM: Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48h post partum. Am J Obstet Gynecol 1996; 174: 975-982. (Pubitemid 26111679)
24. Reddy JK, Mannaerts GP: Peroxisomal lipid metabolism. Annu Rev Nutr 1994; 14: 343-370. (Pubitemid 24261842)
25. Casteels M, Schepers L, Van Veldhoven PP, Eyssen HJ, Mannaerts GP: Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver. J Lipid Res 1990; 31: 1865-1872. (Pubitemid 20387355)
26. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B: Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147-191.
27. Hubel CA, Roberts JM, Taylor RN, Musci TJ, Rogers GM, McLaughlin MK: Lipid peroxidation in pregnancy: new perspectives on preeclampsia. Am J Obstet Gynecol 1989; 161: 1025-1034. (Pubitemid 19266226)
28. Kugiyama K, Doi H, Motoyama T et al: Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 1998; 97: 2519-2526. (Pubitemid 28294498)
29. Mochizuki M, Takada Y, Urano T et al: The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons. Thromb Res 1996; 81: 583-593. (Pubitemid 26101336)
30. Wetzka B, Winkler K, Kinner M, Friedrich I, Marz W, Zahradnik HP: Altered lipid metabolism in preeclampsia and HELLP syndrome: links to enhanced platelet reactivity and fetal growth. Semin Thromb Hemost 1999; 25: 455-462. (Pubitemid 30010800)
31. Ferdinandusse S, Denis S, Dacremont G, Wanders RJ: Toxicity of peroxisomal C27-bile acid intermediates. Mol Genet Metab 2009; 96: 121-128.
32. Takagi Y, Nikaido T, Toki T et al: Levels of oxidative stress and redox-related molecules in the placenta in preeclampsia and fetal growth restriction. Virchows Arch 2004; 444: 49-55. (Pubitemid 38200090)
33. Tranquilli AL, Bezzeccheri V, Giannubilo SR, Scagnoli C, Mazzanti L, Garzetti GG: Amniotic vascular endothelial growth factor (VEGF) and nitric oxide (NO) in women with subsequent preeclampsia. Eur J Obstet Gynecol Reprod Biol 2004; 113: 17-20. (Pubitemid 38281188)
34. Madamanchi NR, Vendrov A, Runge MS: Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol 2005; 25: 29-38. (Pubitemid 40054251)
35. Teslovich TM, Musunuru K, Smith AV et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466: 707-713.
36. Yuen RK, Penaherrera MS, von Dadelszen P, McFadden DE, Robinson WP: DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia. Eur J Hum Genet 2010; 18: 1006-1012.
37. Friedmann E, Hauben E, Maylandt K et al: SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Nat Cell Biol 2006; 8: 843-848. (Pubitemid 44151587)
38. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE: Nod-like proteins in immunity, inflammation and disease. Nat Immunol 2006; 7: 1250-1257. (Pubitemid 46111242)
39. Winn VD, Haimov-Kochman R, Paquet AC et al: Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term. Endocrinology 2007; 148: 1059-1079.
40. Romero R, Espinoza J, Kusanovic JP et al: The preterm parturition syndrome. BJOG 2006; 113 (Suppl 3): 17-42. (Pubitemid 44934664)