STOX2 but not STOX1 is differentially expressed in decidua from preeclamptic women: Data from the Second Nord-Trøndelag Health Study

Molecular Human Reproduction

Volumn 16, Issue 12, 2010, Pages 960-968

  Fenstad, M H ^a   Johnson, M P ^b   Loset M ^a   Mundal, S B ^a   Roten, L T ^a   Eide, I P ^c   Bjorge L ^d   Sande, R K ^d   Johansson, Å K ^a   Dyer, T D ^b   Forsmo, S ^a   Blangero, J ^b   Moses, E K ^b   Austgulen, R ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^d HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Decidua basalis; HUNT2; Intrauterine growth restriction (IUGR); Preeclampsia; STOX genes

Indexed keywords

PROTEIN STOX1; PROTEIN STOX2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DECIDUA; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; INTRAUTERINE GROWTH RETARDATION; NUCLEOTIDE SEQUENCE; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CARRIER PROTEINS; COHORT STUDIES; DECIDUA; FEMALE; FETAL GROWTH RETARDATION; GENE EXPRESSION; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRE-ECLAMPSIA; PREGNANCY;

EID: 77958608068     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq064     Document Type: Article

References (55)

1. ACOG. Practice bulletin: diagnosis and management of preeclampsia and eclampsia, Number 33, January 2002. Obstet Gynecol 2002;99:159-167.
2. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
3. Arngrimsson R, Sigurard TS, Frigge ML, Bjarnadottir RI, Jonsson T, Stefansson H, Baldursdottir A, Einarsdottir AS, Palsson B, Snorradottir S et al. A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 1999;8:1799-1805.
4. Benirschke K, Kaufmann P, Baergen R. Pathology of the Human Placenta, 5th edn. New York, NY, USA: Springer, 2006.
5. Berends AL, Bertoli-Avella AM, de Groot CJ, van Duijn CM, Oostra BA, Steegers EA. STOX1 gene in pre-eclampsia and intrauterine growth restriction. BJOG 2007;114:1163-1167.
6. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972;1:177-191
7. Brosens I, Dixon HG, Robertson WB. Fetal growth retardation and the arteries of the placental bed. Br J Obstet Gynaecol 1977;84:656-663.
8. Brown MA, Mackenzie C, Dunsmuir W, Roberts L, Ikin K, Matthews J, Mangos G, Davis G. Can we predict recurrence of pre-eclampsia or gestational hypertension? BJOG 2007;114:984-993.
9. Conant GC, Wolfe KH. Turning a hobby into a job: how duplicated genes find new functions. Nat Rev Genet 2008;9:938-950.
10. Eide IP, Rolfseng T, Isaksen CV, Mecsei R, Roald B, Lydersen S, Salvesen KA, Harsem NK, Austgulen R. Serious fetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis. Virchows Arch 2006;448:269-276.
11. Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility. Am J Respir Cell Mol Biol 2008;38:57-67.
12. Gifford RW, August PA, Cunningham G, Green LA, Marshall DL, McNellis D, Roberts JM, Sibai BM, Taler SJ. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000;183:1-22.
13. Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, Cole SA, Jowett JB, Abraham LJ, Rainwater DL, Comuzzie AG et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 2007;39:1208-1216.
14. Graves JA. Genomic imprinting, development and disease-is pre-eclampsia caused by a maternally imprinted gene? Reprod Fertil Dev 1998;10:23-29.
15. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakis G, Kaye JA, Turner RJ, Grehan M, Wilton AN et al. A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am J Hum Genet 1997;60:1158-1167.
16. Harsem NK, Staff AC, He L, Roald B. The decidual suction method: a new way of collecting decidual tissue for functional and morphological studies. Acta Obstet Gynecol Scand 2004;83:724-730.
17. Hildrum B, Mykletun A, Hole T, Midthjell K, Dahl AA. Age-specific prevalence of the metabolic syndrome defined by the International Diabetes Federation and the National Cholesterol Education Program: the Norwegian HUNT 2 study. BMC Public Health 2007;7:220.
18. Hittinger CT, Carroll SB. Gene duplication and the adaptive evolution of a classic genetic switch. Nature 2007;449:677-681.
19. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 1990;9:811-818.
20. Holmen J, Midthjell K, Kruger Ø, Langhammer A, Holmen TL, Bratberg GH, Vatten LJ, Lund-Larsen PG. The Nord-Trøndelag Health Study 1995-1997 (HUNT2): objectives, contents, methods and participation. Nor J Epidemiol 2003;13:19-32.
21. Hughes AL. Gene duplication and the origin of novel proteins. Proc Natl Acad Sci USA 2005;102:8791-8792.
22. Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008;51:970-975.
23. Iglesias-Platas I, Monk D, Jebbink J, Buimer M, Boer K, van der PJ, Hills F, Apostolidou S, Ris-Stalpers C, Stanier P et al. STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nat Genet 2007;39:279-280.
24. Jensen RA. Enzyme recruitment in evolution of new function. Annu Rev Microbiol 1976;30:409-425.
25. Johnson MP, Fitzpatrick E, Dyer TD, Jowett JB, Brennecke SP, Blangero J, Moses EK. Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach. Mol Hum Reprod 2007;13:61-67.
26. Kivinen K, Peterson H, Hiltunen L, Laivuori H, Heino S, Tiala I, Knuutila S, Rasi V, Kere J. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur J Hum Genet 2007;15:494-497.
27. Lachmeijer AM, Arngrimsson R, Bastiaans EJ, Frigge ML, Pals G, Sigurdardottir S, Stefansson H, Palsson B, Nicolae D, Kong A et al. A genome-wide scan for preeclampsia in the Netherlands. Eur J Hum Genet 2001;9:758-764.
28. Laivuori H, Lahermo P, Ollikainen V, Widen E, Haiva-Mallinen L, Sundstrom H, Laitinen T, Kaaja R, Ylikorkala O, Kere J. Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am J Hum Genet 2003;72:168-177.
29. Lalouel JM, Rohrwasser A. Power and replication in case-control studies. Am J Hypertens 2002;15:201-205.
30. Marsal K, Persson PH, Larsen T, Lilja H, Selbing A, Sultan B. Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr 1996;85:843-848.
31. Moses EK, Lade JA, Guo G, Wilton AN, Grehan M, Freed K, Borg A, Terwilliger JD, North R, Cooper DW et al. A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. Am J Hum Genet 2000;67:1581-1585.
32. Moses EK, Fitzpatrick E, Freed KA, Dyer TD, Forrest S, Elliott K, Johnson MP, Blangero J, Brennecke SP. Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22. Mol Hum Reprod 2006;12:505-512.
33. Moses EK, Johnson MP, Tommerdal L, Forsmo S, Curran JE, Abraham LJ, Charlesworth JC, Brennecke SP, Blangero J, Austgulen R. Genetic association of preeclampsia to the inflammatory response gene SEPS1. Am J Obstet Gynecol 2007;198:336.e1-336.e5.
34. Mostello D, Catlin TK, Roman L, Holcomb WL Jr, Leet T. Preeclampsia in the parous woman: who is at risk? Am J Obstet Gynecol 2002;187:425-429.
35. Ness RB, Roberts JM. Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol 1996;175:1365-1370.
36. Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol 2006;195:40-49.
37. Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Risk factors and clinical manifestations of pre-eclampsia. BJOG 2000;107:1410-1416.
38. Oudejans CB, van Dijk M. Placental gene expression and pre-eclampsia. Placenta 2008;29(Suppl. A):78-82.
39. Oudejans CB, Mulders J, Lachmeijer AM, van Dijk M, Konst AA, Westerman BA, van Wijk I, Leegwater PA, Kato HD, Matsuda T et al. The parent-of-origin effect of 10q22 in pre-eclamptic females coincides with two regions clustered for genes with down-regulated expression in androgenetic placentas. Mol Hum Reprod 2004;10:589-598.
40. Oudejans CB, van Dijk M, Oosterkamp M, Lachmeijer A, Blankenstein MA. Genetics of preeclampsia: paradigm shifts. Hum Genet 2007;120:607-612.
41. Rigourd V, Chauvet C, Chelbi ST, Rebourcet R, Mondon F, Letourneur F, Mignot TM, Barbaux S, Vaiman D. STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. PLoS ONE 2008;3:e3905.
42. Rigourd V, Chelbi S, Chauvet C, Rebourcet R, Barbaux S, Bessieres B, Mondon F, Mignot TM, Danan JL, Vaiman D. Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsia. J Reprod Immunol 2009;82:174-181.
43. Roten LT, Johnson MP, Forsmo S, Fitzpatrick E, Dyer TD, Brennecke SP, Blangero J, Moses EK, Austgulen R. Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). Eur J Hum Genet 2008;17:250-257.
44. Salonen RH, Lichtenstein P, Lipworth L, Cnattingius S. Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet 2000;91:256-260.
45. Sheridan C. Intrauterine growth restriction-diagnosis and management. Aust Fam Physician 2005;34:717-723.
46. Sibai BM, el-Nazer A, Gonzalez-Ruiz A. Severe preeclampsia-eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol 1986;155:1011-1016.
47. Sibai BM, Mercer B, Sarinoglu C. Severe preeclampsia in the second trimester: recurrence risk and long-term prognosis. Am J Obstet Gynecol 1991;165:1408-1412.
48. Srinivas SK, Edlow AG, Neff PM, Sammel MD, Andrela CM, Elovitz MA. Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension? J Perinatol 2009;29:680-684.
49. Staff AC, Ranheim T, Khoury J, Henriksen T. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia. Am J Obstet Gynecol 1999;180:587-592.
50. Thomas S, Thomas M, Wincker P, Babarit C, Xu P, Speer MC, Munnich A, Lyonnet S, Vekemans M, Etchevers HC. Human neural crest cells display molecular and phenotypic hallmarks of stem cells. Hum Mol Genet 2008;17:3411-3425.
51. Trogstad LI, Eskild A, Magnus P, Samuelsen SO, Nesheim BI. Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. A study of 547 238 women with and without previous pre-eclampsia. Int J Epidemiol 2001;30:1317-1322.
52. van Dijk M, Mulders J, Poutsma A, Konst AA, Lachmeijer AM, Dekker GA, Blankenstein MA, Oudejans CB. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat Genet 2005;37:514-519.
53. van Dijk M, van Bezu J, Chim SS, Lo YM, Blankenstein MA, Oudejans CB. Reply to 'STOX1 is not imprinted and is not likely to be involved in preeclampsia'. Nat Genet 2007;39:280-281.
54. van Dijk M, van Bezu J, Poutsma A, Veerhuis R, Rozemuller AJ, Scheper W, Blankenstein MA, Oudejans CB. The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain up-regulated in late-onset Alzheimer's disease. J Alzheimers Dis 2010a;19:673-679.
55. van Dijk M, van Bezu J, van Abel D, Dunk C, Blankenstein MA, Oudejans CB, Lye SJ. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by a-T-catenin up-regulation. Hum Mol Genet 2010b;19:2658-2667.