Risk factors for false-negative results of QuantiFERON-TB Gold In-Tube assay in non-HIV-infected patients with culture-confirmed tuberculosis

Diagnostic Microbiology and Infectious Disease

Volumn 70, Issue 3, 2011, Pages 324-329

  Kim, Eun Young ^a   Park, Moo Suk ^a   Kim, Young Sam ^a   Kim, Se Kyu ^a   Chang, Joon ^a   Kang, Young Ae ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Diagnosis; False negative; QuantiFERON TB Gold In Tube; Tuberculosis

Indexed keywords

ALBUMIN; GAMMA INTERFERON; PROTEIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BACTERIUM CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRAPULMONARY TUBERCULOSIS; FALSE NEGATIVE RESULT; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPROMISED PATIENT; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SOUTH KOREA; SPUTUM SMEAR; TERTIARY HEALTH CARE; THORAX RADIOGRAPHY; THROMBOCYTE COUNT; TUBERCULOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CLINICAL LABORATORY TECHNIQUES; FALSE NEGATIVE REACTIONS; FEMALE; HOSPITALS; HUMANS; IMMUNOASSAY; MALE; MIDDLE AGED; REPUBLIC OF KOREA; RISK FACTORS; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS; YOUNG ADULT;

EID: 79959228145     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2011.02.011     Document Type: Article

References (23)

1. Aber V.R., Allen B.W., Mitchison D.A., Ayuma P., Edwards E.A., Keyes A.B. Quality control in tuberculosis bacteriology. 1. Laboratory studies on isolated positive cultures and the efficiency of direct smear examination. Tubercle 1980, 61:123-133.
2. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am. J. Respir. Crit. Care. Med. 2000, 161:S221-S247. American Thoracic Society.
3. Andersen P., Munk M.E., Pollock J.M., Doherty T.M. Specific immune-based diagnosis of tuberculosis. Lancet 2000, 356:1099-1104.
4. Ashwell J.D., Lu F.W., Vacchio M.S. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 2000, 18:309-345.
5. Boehme C.C., Nabeta P., Hillemann D., Nicol M.P., Shenai S., Krapp F., Allen J., Tahirli R., Blakemore R., Rustomjee R., Milovic A., Jones M., O'Brien S.M., Persing D.H., Ruesch-Gerdes S., Gotuzzo E., Rodrigues C., Alland D., Perkins M.D. Rapid molecular detection of tuberculosis and rifampin resistance. N. Engl. J. Med. 2010, 363:1005-1015.
6. Chinen J., Shearer W.T. Secondary immunodeficiencies, including HIV infection. J. Allergy. Clin. Immunol. 2010, 125:S195-S203.
7. Dewan P.K., Grinsdale J., Kawamura L.M. Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis. Clin. Infect. Dis. 2007, 44:69-73.
8. Diel R., Loddenkemper R., Nienhaus A. Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis. Chest 2010, 137:952-968.
9. Elzey B.D., Sprague D.L., Ratliff T.L. The emerging role of platelets in adaptive immunity. Cell. Immunol. 2005, 238:1-9.
10. Greco S., Girardi E., Navarra A., Saltini C. Current evidence on diagnostic accuracy of commercially based nucleic acid amplification tests for the diagnosis of pulmonary tuberculosis. Thorax 2006, 61:783-790.
11. Kang Y.A., Lee H.W., Hwang S.S., Um S.W., Han S.K., Shim Y.S., Yim J.J. Usefulness of whole-blood interferon-gamma assay and interferon-gamma enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis. Chest 2007, 132:959-965.
12. Kim S.H., Choi S.J., Kim H.B., Kim N.J., Oh M.D., Choe K.W. Diagnostic usefulness of a T-cell based assay for extrapulmonary tuberculosis. Arch. Intern. Med. 2007, 167:2255-2259.
13. Kobashi Y., Mouri K., Yagi S., Obase Y., Miyashita N., Okimoto N., Matsushima T., Kageoka T., Oka M. Clinical utility of the QuantiFERON TB-2G test for elderly patients with active tuberculosis. Chest 2008, 133:1196-1202.
14. Kobashi Y., Shimizu H., Ohue Y., Mouri K., Obase Y., Miyashita N., Oka M. False negative results of QuantiFERON TB-2G test in patients with active tuberculosis. Jpn. J. Infect. Dis. 2009, 62:300-302.
15. Li Z., Yang F., Dunn S., Gross A.K., Smyth S.S. Platelets as immune mediators: Their role in host defense responses and sepsis. Thromb. Res. 2011, 127:184-188.
16. Liao C.H., Lai C.C., Tan C.K., Chou C.H., Hsu H.L., Tasi T.H., Huang Y.T., Hsueh P.R. False-negative results by enzyme-linked immunospot assay for interferon-gamma among patients with culture-confirmed tuberculosis. J. Infect. 2009, 59:421-423.
17. Menzies D. Using tests for latent tuberculous infection to diagnose active tuberculosis: can we eat our cake and have it too?. Ann. Intern. Med. 2008, 148:398-399.
18. Ravn P., Munk M.E., Andersen A.B., Lundgren B., Lundgren J.D., Nielsen L.N., Kok-Jensen A., Andersen P., Weldingh K. Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis. Clin. Diagn. Lab. Immunol. 2005, 12:491-496.
19. Semple J.W., Freedman J. Platelets and innate immunity. Cell. Mol. Life Sci. 2010, 67:499-511.
20. Siddiqi K., Lambert M.L., Walley J. Clinical diagnosis of smear-negative pulmonary tuberculosis in low-income countries: the current evidence. Lancet Infect. Dis. 2003, 3:288-296.
21. Song K.H., Jeon J.H., Park W.B., Kim S.H., Park K.U., Kim N.J., Oh M.D., Kim H.B., Choe K.W. Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis. Diagn. Microbiol. Infect. Dis. 2009, 63:182-187.
22. Vikram H.R., Kusne S. Mycobacterium tuberculosis infection in immunocompromised hosts: a diagnostic challenge. Liver Transpl. 2009, 15:834-837.
23. Global tuberculosis control: a short update to the 2009 report 2009, World Health Organization, World Health Organization., Geneva.