Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Ma, Hongxia ^a,b   Wang, Li E ^a   Liu, Zhensheng ^a   Sturgis, Erich M ^a   Wei, Qingyi ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

PLCE1; polymorphism; risk; SCCHN; susceptibility

Indexed keywords

PHOSPHOLIPASE C; PHOSPHOLIPASE C EPSILON1; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PHOSPHOLIPASE C EPSILON; TUMOR PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CANCER LOCALIZATION; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CAUCASIAN; CONTROLLED STUDY; ESOPHAGUS CANCER; FEMALE; GENE DOSAGE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEAD AND NECK CARCINOMA; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; AGED; ALLELE; ANTIBODY SPECIFICITY; CASE CONTROL STUDY; COCARCINOGENESIS; DNA SEQUENCE; DRINKING BEHAVIOR; ESOPHAGUS TUMOR; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HEAD AND NECK TUMOR; MIDDLE AGED; PHYSIOLOGY; RISK; RISK FACTOR; SQUAMOUS CELL CARCINOMA; STOMACH TUMOR; UNITED STATES;

AGED; ALCOHOL DRINKING; ALLELES; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; COCARCINOGENESIS; ESOPHAGEAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HAPLOTYPES; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ORGAN SPECIFICITY; PHOSPHOINOSITIDE PHOSPHOLIPASE C; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; RISK FACTORS; SEQUENCE ANALYSIS, DNA; SMOKING; STOMACH NEOPLASMS; UNITED STATES;

EID: 79959209735     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-258     Document Type: Article

References (30)

1. Marcu LG, Yeoh E. A review of risk factors and genetic alterations in head and neck carcinogenesis and implications for current and future approaches to treatment. J Cancer Res Clin Oncol 2009, 135(10):1303-1314. 10.1007/s00432-009-0648-7, 19641938.
2. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60(5):277-300. 10.3322/caac.20073, 20610543.
3. Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers?. Cancer 2007, 110(7):1429-1435. 10.1002/cncr.22963, 17724670.
4. Neumann AS, Sturgis EM, Wei Q. Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. Mol Carcinog 2005, 42(2):65-92. 10.1002/mc.20069, 15682379.
5. Ho T, Wei Q, Sturgis EM. Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck. Head Neck 2007, 29(7):682-699. 10.1002/hed.20570, 17274053.
6. Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature 2004, 429(6990):446-452. 10.1038/nature02623, 15164069.
7. Stadler ZK, Thom P, Robson ME, Weitzel JN, Kauff ND, Hurley KE, Devlin V, Gold B, Klein RJ, Offit K. Genome-Wide Association Studies of Cancer. J Clin Oncol 2010, 28(27):4255-4267. 10.1200/JCO.2009.25.7816, 20585100.
8. McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, et al. A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. PLoS Genet 2011, 7(3):e1001333. 10.1371/journal.pgen.1001333, 3060072, 21437268.
9. Wang LD, Zhou FY, Li XM, Sun LD, Song X, Jin Y, Li JM, Kong GQ, Qi H, Cui J, Zhang LQ, Yang JZ, Li JL, Li XC, Ren JL, Liu ZC, Gao WJ, Yuan L, Wei W, Zhang YR, Wang WP, Sheyhidin I, Li F, Chen BP, Ren SW, Liu B, Li D, Ku JW, Fan ZM, Zhou SL, et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet 2010, 42(9):759-763. 10.1038/ng.648, 20729853.
10. Abnet CC, Freedman ND, Hu N, Wang Z, Yu K, Shu XO, Yuan JM, Zheng W, Dawsey SM, Dong LM, Lee MP, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Wang C, Wheeler W, Gail MH, Yeager M, Yuenger J, Hutchinson A, Jacobs KB, Giffen CA, Burdett L, Fraumeni JF, Tucker MA, Chow WH, et al. A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet 42(9):764-767.
11. Wing MR, Bourdon DM, Harden TK. PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Mol Interv 2003, 3(5):273-280. 10.1124/mi.3.5.273, 14993441.
12. Li M, Edamatsu H, Kitazawa R, Kitazawa S, Kataoka T. Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis 2009, 30(8):1424-1432. 10.1093/carcin/bgp125, 19458037.
13. Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, Kataoka T. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res 2004, 64(24):8808-8810. 10.1158/0008-5472.CAN-04-3143, 15604236.
14. Ou L, Guo Y, Luo C, Wu X, Zhao Y, Cai X. RNA interference suppressing PLCE1 gene expression decreases invasive power of human bladder cancer T24 cell line. Cancer Genet Cytogenet 200(2):110-119.
15. Wang X, Zbou C, Qiu G, Fan J, Tang H, Peng Z. Screening of new tumor suppressor genes in sporadic colorectal cancer patients. Hepatogastroenterology 2008, 55(88):2039-2044.
16. Bourguignon LY, Gilad E, Brightman A, Diedrich F, Singleton P. Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J Biol Chem 2006, 281(20):14026-14040. 10.1074/jbc.M507734200, 16565089.
17. Mehanna H, Paleri V, West CM, Nutting C. Head and neck cancer--Part 1: Epidemiology, presentation, and prevention. BMJ 2010, 341:c4684. 10.1136/bmj.c4684, 20855405.
18. Morita M, Kumashiro R, Kubo N, Nakashima Y, Yoshida R, Yoshinaga K, Saeki H, Emi Y, Kakeji Y, Sakaguchi Y, Toh Y, Maehara Y. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. Int J Clin Oncol 2010, 15(2):126-134. 10.1007/s10147-010-0056-7, 20224884.
19. Steevens J, Schouten LJ, Goldbohm RA, van den Brandt PA. Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study. Gut 2010, 59(1):39-48. 10.1136/gut.2009.191080, 19828467.
20. Liu Z, Calderon JI, Zhang Z, Sturgis EM, Spitz MR, Wei Q. Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer. Pharmacogenet Genomics 2005, 15(3):159-165. 10.1097/01213011-200503000-00004, 15861040.
21. Huang YJ, Niu J, Liu Z, Wang LE, Sturgis EM, Wei Q. The functional IGFBP7 promoter -418G > A polymorphism and risk of head and neck cancer. Mutat Res 2010, 702(1):32-39.
22. Xu Z, Taylor JA. SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res 2009, 37(Web Server issue):W600-605. 2703930, 19417063.
23. Bunney TD, Baxendale RW, Katan M. Regulatory links between PLC enzymes and Ras superfamily GTPases: signalling via PLCepsilon. Adv Enzyme Regul 2009, 49(1):54-58. 10.1016/j.advenzreg.2009.01.004, 19534025.
24. Kelley GG, Reks SE, Ondrako JM, Smrcka AV. Phospholipase C(epsilon): a novel Ras effector. EMBO J 2001, 20(4):743-754. 10.1093/emboj/20.4.743, 145421, 11179219.
25. Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW. A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J Biol Chem 2001, 276(4):2758-2765. 10.1074/jbc.M008119200, 11022047.
26. Sorli SC, Bunney TD, Sugden PH, Paterson HF, Katan M. Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants. Oncogene 2005, 24(1):90-100. 10.1038/sj.onc.1208168, 15558028.
27. Gbadegesin R, Hinkes BG, Hoskins BE, Vlangos CN, Heeringa SF, Liu J, Loirat C, Ozaltin F, Hashmi S, Ulmer F, Cleper R, Ettenger R, Antignac C, Wiggins RC, Zenker M, Hildebrandt F. Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). Nephrol Dial Transplant 2008, 23(4):1291-1297.
28. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 2000, 92(9):709-720. 10.1093/jnci/92.9.709, 10793107.
29. D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 2007, 356(19):1944-1956. 10.1056/NEJMoa065497, 17494927.
30. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005, 14(2):467-475. 10.1158/1055-9965.EPI-04-0551, 15734974.