Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: A review

Journal of Cardiovascular Magnetic Resonance

Volumn 11, Issue 1, 2009, Pages

  Butler, Craig R ^a   Thompson, Richard ^a   Haykowsky, Mark ^a   Toma, Mustafa ^a   Paterson, Ian ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; CYCLOSPORIN; GADOLINIUM; IMMUNOSUPPRESSIVE AGENT; IRON OXIDE; CONTRAST MEDIUM;

ACUTE GRAFT REJECTION; ALLOGRAFT; BLOOD VESSEL PERMEABILITY; CARDIAC GRAFT REJECTION; CELL INFILTRATION; CELLULAR DISTRIBUTION; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIASTOLE; DIFFUSION WEIGHTED IMAGING; DRUG SAFETY; DRUG TISSUE LEVEL; HEART MUSCLE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HEART VENTRICLE FUNCTION; HUMAN; IMAGE ENHANCEMENT; IMAGE QUALITY; MACROPHAGE; MYOCARDITIS; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REPRODUCIBILITY; REVIEW; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SYSTOLE; TISSUE STRUCTURE; TREATMENT INDICATION; ACUTE DISEASE; GRAFT REJECTION; METHODOLOGY;

ACUTE DISEASE; CONTRAST MEDIA; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; MAGNETIC RESONANCE IMAGING;

EID: 67049088733     PISSN: 10976647     EISSN: 1532429X     Source Type: Journal    
DOI: 10.1186/1532-429X-11-7     Document Type: Review

References (84)

1. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Waltz DA, Keck BM, Hertz MI: Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report - 2006. J Heart Lung Transplant 2006, 25: 869-879. (Pubitemid 44143013)
2. Nielsen H, Sorensen FB, Nielsen B, Bagger JP, Thayssen P, Baandrup U: Reproducibility of the acute rejection diagnosis in human cardiac allografts. The Stanford Classification and the International Grading System. J Heart Lung Transplant 1993, 12: 239-243. (Pubitemid 23123865)
3. Gradek WQ, D'Amico C, Smith AL, Vega D, Book WM: Routine surveillance endomyocardial biopsy continues to detect significant rejection late after heart transplantation. J Heart Lung Transplant 2001, 20: 497-502. (Pubitemid 32410010)
4. Lindenfeld J, Miller GG, Shakar SF, Zolty R, Lowes BD, Wolfel EE, Mestroni L, Page RL 2nd, Kobashigawa J: Drug therapy in the heart transplant recipient: part I: cardiac rejection and immunosuppressive drugs. Circulation 2004, 110: 3734-3740. (Pubitemid 39665265)
5. Caves PK, Stinson EB, Billingham M, Shumway NE: Percutaneous transvenous endomyocardial biopsy in human heart recipients. Experience with a new technique. Ann Thorac Surg 1973, 16: 325-336.
6. Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J, Andersen CB, Angelini A, Berry GJ, Burke MM, et al.: Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005, 24: 1710-1720. (Pubitemid 41641841)
7. Baraldi-Junkins C, Levin HR, Kasper EK, Rayburn BK, Herskowitz A, Baughman KL: Complications of endomyocardial biopsy in heart transplant patients. J Heart Lung Transplant 1993, 12: 63-67. (Pubitemid 23099861)
8. Huddleston CB, Rosenbloom M, Goldstein JA, Pasque MK: Biopsyinduced tricuspid regurgitation after cardiac transplantation. Ann Thorac Surg 1994, 57: 832-836. (Pubitemid 24133463)
9. Spiegelhalter DJ, Stovin PG: An analysis of repeated biopsies following cardiac transplantation. Stat Med 1983, 2: 33-40.
10. Winters GL, McManus BM: Consistencies and controversies in the application of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment Trial Pathologists. J Heart Lung Transplant 1996, 15: 728-735.
11. Marboe CC, Billingham M, Eisen H, Deng MC, Baron H, Mehra M, Hunt S, Wohlgemuth J, Mahmood I, Prentice J, Berry G: Nodular endocardial infiltrates (Quilty lesions) cause significant variability in diagnosis of ISHLT Grade 2 and 3A rejection in cardiac allograft recipients. J Heart Lung Transplant 2005, 24: S219-226. (Pubitemid 40922653)
12. Yeoh TK, Frist WH, Eastburn TE, Atkinson J: Clinical significance of mild rejection of the cardiac allograft. Circulation 1992, 86: II267-271.
13. Valantine HA, Yeoh TK, Gibbons R, McCarthy P, Stinson EB, Billingham ME, Popp RL: Sensitivity and specificity of diastolic indexes for rejection surveillance: temporal correlation with endomyocardial biopsy. J Heart Lung Transplant 1991, 10: 757-765.
14. Knosalla C, Hummel M, Muller J, Grauhan O, Ewert R, Hetzer R: Diagnosis of heart graft rejection. Current Opinion in Organ Transplantation 2000, 5: 118-125.
15. Yun KL, Niczyporuk MA, Daughters GT II, Ingels NB Jr, Stinson EB, Alderman EL, Hansen DE, Miller DC: Alterations in left ventricular diastolic twist mechanics during acute human cardiac allograft rejection. Circulation 1991, 83: 962-973.
16. Marie PY, Angioi M, Carteaux JP, Escanye JM, Mattei S, Tzvetanov K, Claudon O, Hassan N, Danchin N, Karcher G, et al.: Detection and prediction of acute heart transplant rejection with the myocardial T2 determination provided by a black-blood magnetic resonance imaging sequence. J Am Coll Cardiol 2001, 37: 825-831. (Pubitemid 32202451)
17. Desruennes M, Corcos T, Cabrol A, Gandjbakhch I, Pavie A, Leger P, Eugene M, Bors V, Cabrol C: Doppler echocardiography for the diagnosis of acute cardiac allograft rejection. J Am Coll Cardiol 1988, 12: 63-70. (Pubitemid 18158025)
18. Vivekananthan K, Kalapura T, Mehra M, Lavie C, Milani R, Scott R, Park M: Usefulness of the combined index of systolic and diastolic myocardial performance to identify cardiac allograft rejection. Am J Cardiol 2002, 90: 517-520. (Pubitemid 35246042)
19. Moidl R, Chevtchik O, Simon P, Grimm M, Wieselthaler G, Ullrich R, Mittlbock M, Wolner E, Laufer G: Noninvasive monitoring of peak filling rate with acoustic quantification echocardiography accurately detects acute cardiac allograft rejection. J Heart Lung Transplant 1999, 18: 194-201. (Pubitemid 29177896)
20. Marie PY, Carteaux JP, Angioi M, Marwan NS, Tzvetanov K, Escanye JM, David N, Mattei S, Danchin N, Karcher G, et al.: Detection and prediction of acute heart transplant rejection: preliminary results on the clinical use of a "black blood" magnetic resonance imaging sequence. Transplant Proc 1998, 30: 1933-1935. (Pubitemid 28399377)
21. Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, Pennell DJ: Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J 2000, 21: 1387-1396. (Pubitemid 30599134)
22. Bellenger NG, Marcus NJ, Davies C, Yacoub M, Banner NR, Pennell DJ: Left ventricular function and mass after orthotopic heart transplantation: a comparison of cardiovascular magnetic resonance with echocardiography. J Heart Lung Transplant 2000, 19: 444-452. (Pubitemid 30249082)
23. Bellenger NG, Marcus NJ, Rajappan K, Yacoub M, Banner NR, Pennell DJ: Comparison of techniques for the measurement of left ventricular function following cardiac transplantation. J Cardiovasc Magn Reson 2002, 4: 255-263. (Pubitemid 34596286)
24. Paelinck BP, Lamb HJ, Bax JJ, Wall EE Van der, de Roos A: Assessment of diastolic function by cardiovascular magnetic resonance. Am Heart J 2002, 144: 198-205. (Pubitemid 34879638)
25. Aletras AH, Tilak GS, Natanzon A, Hsu LY, Gonzalez FM, Hoyt RF Jr, Arai AE: Retrospective determination of the area at risk for reperfused acute myocardial infarction with T2-weighted cardiac magnetic resonance imaging: histopathological and displacement encoding with stimulated echoes (DENSE) functional validations. Circulation 2006, 113: 1865-1870. (Pubitemid 43739398)
26. Abdel-Aty H, Boye P, Zagrosek A, Wassmuth R, Kumar A, Messroghli D, Bock P, Dietz R, Friedrich MG, Schulz-Menger J: Diagnostic performance of cardiovascular magnetic resonance in patients with suspected acute myocarditis: comparison of different approaches. J Am Coll Cardiol 2005, 45: 1815-1822. (Pubitemid 40779862)
27. Abdel-Aty H, Cocker M, Friedrich MG: Myocardial edema is a feature of Tako-Tsubo cardiomyopathy and is related to the severity of systolic dysfunction: Insights from T2-weighted cardiovascular magnetic resonance. Int J Cardiol 2007.
28. De Cobelli F, Pieroni M, Esposito A, Chimenti C, Belloni E, Mellone R, Canu T, Perseghin G, Gaudio C, Maseri A, et al.: Delayed gadolinium-enhanced cardiac magnetic resonance in patients with chronic myocarditis presenting with heart failure or recurrent arrhythmias. J Am Coll Cardiol 2006, 47: 1649-1654.
29. Aherne T, Tscholakoff D, Finkbeiner W, Sechtem U, Derugin N, Yee E, Higgins CB: Magnetic resonance imaging of cardiac transplants: the evaluation of rejection of cardiac allografts with and without immunosuppression. Circulation 1986, 74: 145-156. (Pubitemid 16092935)
30. Huber DJ, Kirkman RL, Kupiec-Weglinski JW, Araujo JL, Tilney NL, Adams DF: The detection of cardiac allograft rejection by alterations in proton NMR relaxation times. Invest Radiol 1985, 20: 796-802. (Pubitemid 16234403)
31. Sasaguri S, Sunamori M, Saito K, Suzuki A: Early change of myocardial water during acute cardiac allograft rejection. Jpn Circ J 1986, 50: 1113-1119. (Pubitemid 17002911)
32. Lund G, Morin RL, Olivari MT, Ring WS: Serial myocardial T2 relaxation time measurements in normal subjects and heart transplant recipients. J Heart Transplant 1988, 7: 274-279. (Pubitemid 18200256)
33. Wisenberg G, Pflugfelder PW, Kostuk WJ, McKenzie FN, Prato FS: Diagnostic applicability of magnetic resonance imaging in assessing human cardiac allograft rejection. Am J Cardiol 1987, 60: 130-136. (Pubitemid 17125662)
34. Smart FW, Young JB, Weilbaecher D, Kleiman NS, Wendt RE III, Johnston DL: Magnetic resonance imaging for assessment of tissue rejection after heterotopic heart transplantation. J Heart Lung Transplant 1993, 12: 403-410. (Pubitemid 23183532)
35. Almenar L, Igual B, Martinez-Dolz L, Arnau MA, Osa A, Rueda J, Palencia M: Utility of cardiac magnetic resonance imaging for the diagnosis of heart transplant rejection. Transplant Proc 2003, 35: 1962-1964. (Pubitemid 37093780)
36. Mousseaux E, Farge D, Guillemain R, Bruneval P, Vulser C, Couetil JP, Carpentier A, Gaux JC: Assessing human cardiac allograft rejection using MRI with Gd-DOTA. J Comput Assist Tomogr 1993, 17: 237-244. (Pubitemid 23086439)
37. Doornbos J, Verwey H, Essed CE, Balk AH, de Roos A: MR imaging in assessment of cardiac transplant rejection in humans. J Comput Assist Tomogr 1990, 14: 77-81. (Pubitemid 20039448)
38. Revel D, Chapelon C, Mathieu D, Cochet P, Ninet J, Chuzel M, Champsaur G, Dureau G, Amiel M, Helenon O, et al.: Magnetic resonance imaging of human orthotopic heart transplantation: correlation with endomyocardial biopsy. J Heart Transplant 1989, 8: 139-146. (Pubitemid 19101452)
39. Abdel-Aty H, Zagrosek A, Schulz-Menger J, Taylor AJ, Messroghli D, Kumar A, Gross M, Dietz R, Friedrich MG: Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 2004, 109: 2411-2416. (Pubitemid 38679560)
40. Sasaguri S, LaRaia PJ, Fabri BM, Fallon JT, Ayelsworth CA, D'Ambra MN, Newell JB, Brady TJ, Buckley MJ: Early detection of cardiac allograft rejection with proton nuclear magnetic resonance. Circulation 1985, 72: II231-236.
41. Tscholakoff D, Aherne T, Yee ES, Derugin N, Higgins CB: Cardiac transplantations in dogs: evaluation with MR. Radiology 1985, 157: 697-702. (Pubitemid 16232112)
42. Kurland RJ, West J, Kelley S, Shoop JD, Harris R, Carr EA Jr, Bergsland J, Wright J, Carroll M: Magnetic resonance imaging to detect heart transplant rejection: sensitivity and specificity. Transplant Proc 1989, 21: 2537-2543. (Pubitemid 19124451)
43. Sasaki H, Sada M, Nishimura T, Yutani C, Nakatani H, Yaku H, Yamaguchi T, Kawazoe K, Amemiya H, Fujita T: The expanded scope of effectiveness of nuclear magnetic resonance imaging to determine cardiac allograft rejection. Transplant Proc 1987, 19: 1062-1064. (Pubitemid 17026750)
44. Nishimura T, Sada M, Sasaki H, Yutani C, Fujita T, Amemiya H, Kozuka T, Akutsu T, Manabe H: Assessment of severity of cardiac rejection in heterotopic heart transplantation using indium-111 antimyosin and magnetic resonance imaging. Cardiovasc Res 1988, 22: 108-112. (Pubitemid 18065823)
45. Nishimura T, Sada M, Sasaki H, Yutani C, Kozuka T, Amemiya H, Fujita T, Akutsu T, Manabe H: Identification of cardiac rejection with magnetic resonance imaging in heterotopic heart transplantation model. Heart Vessels 1987, 3: 135-140. (Pubitemid 18028960)
46. Billingham ME: Diagnosis of cardiac rejection by endomyocardial biopsy. Heart transplantation 1982, 1: 25-30.
47. Billingham ME, Cary NR, Hammond ME, Kemnitz J, Marboe C, McCallister HA, Snovar DC, Winters GL, Zerbe A: A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990, 9: 587-593.
48. McAllister HA Jr: Histologic grading of cardiac allograft rejection: a quantitative approach. J Heart Transplant 1990, 9: 277-282.
49. Abdel-Aty H, Simonetti O, Friedrich MG: T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging 2007, 26: 452-459. (Pubitemid 350194566)
50. Simonetti OP, Finn JP, White RD, Laub G, Henry DA: "Black blood" T2-weighted inversion-recovery MR imaging of the heart. Radiology 1996, 199: 49-57. (Pubitemid 26095814)
51. Pereira NL, Zile MR, Harley RA, Van Bakel AB: Myocardial mechanisms causing heart failure early after cardiac transplantation. Transplant Proc 2006, 38: 2999-3003. (Pubitemid 44737917)
52. Albers J, Schroeder A, de Simone R, Mockel R, Vahl CF, Hagl S: 3D evaluation of myocardial edema: experimental study on 22 pigs using magnetic resonance and tissue analysis. Thorac Cardiovasc Surg 2001, 49: 199-203. (Pubitemid 32776888)
53. Vahl CF, Albers J, Makabe MH, Meinzer HP, Ilg M, Fu X, Szabo G, Muhling J, Hagl S: Heterogeneity of myocardial edema in isolated pig hearts after perfusion with different types of cardioprotective solutions. Thorac Cardiovasc Surg 1998, 46: 285-292. (Pubitemid 28562039)
54. Poon CS, Henkelman RM: Practical T2 quantitation for clinical applications. J Magn Reson Imaging 1992, 2: 541-553.
55. Bottomley PA, Foster TH, Argersinger RE, Pfeifer LM: A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: dependence on tissue type, NMR frequency, temperature, species, excision, and age. Med Phys 1984, 11: 425-448.
56. He T, Gatehouse PD, Anderson LJ, Tanner M, Keegan J, Pennell DJ, Firmin DN: Development of a novel optimized breathhold technique for myocardial T2 measurement in thalassemia. J Magn Reson Imaging 2006, 24: 580-585. (Pubitemid 44320560)
57. He T, Kirk P, Firmin DN, Lam WM, Chu WC, Au WY, Chan GC, Tan RS, Ng I, Biceroglu S, et al.: Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. J Cardiovasc Magn Reson 2008, 10: 11.
58. Nishimura T, Sada M, Sasaki H, Amemiya H, Kozuka T, Fujita T, Akutsu T, Manabe H: Cardiac transplantation in dogs: evaluation with gated MRI and Gd-DTPA contrast enhancement. Heart Vessels 1987, 3: 141-145. (Pubitemid 18028961)
59. Konstam MA, Aronovitz MJ, Runge VM, Kaufman DM, Brockway BA, Isner JM, Katzen NA, Dresdale AR, Diehl JT, Kaplan E, et al.: Magnetic resonance imaging with gadolinium-DTPA for detecting cardiac transplant rejection in rats. Circulation 1988, 78: III87-94. (Pubitemid 18272383)
60. Ciliberto GR, Mascarello M, Gronda E, Bonacina E, Anjos MC, Danzi G, Colombo P, Frigerio M, Alberti A, De Vita C: Acute rejection after heart transplantation: noninvasive echocardiographic evaluation. J Am Coll Cardiol 1994, 23: 1156-1161. (Pubitemid 24117150)
61. Walpoth BH, Muller MF, Celik B, Nicolaus B, Walpoth N, Schaffner T, Althaus U, Carrel T: Assessment of cardiac rejection by MRimaging and MR-spectroscopy. Eur J Cardiothorac Surg 1998, 14: 426-430. (Pubitemid 28520133)
62. Yoshida S, Dodd SJ, del Nido PJ, Williams DS, Ho C: Cardiac function of transplanted rat hearts using a working heart model assessed by magnetic resonance imaging. J Heart Lung Transplant 1999, 18: 1054-1064.
63. McNamara D, Di Salvo T, Mathier M, Keck S, Semigran M, Dec GW: Left ventricular dysfunction after heart transplantation: incidence and role of enhanced immunosuppression. J Heart Lung Transplant 1996, 15: 506-515. (Pubitemid 26171248)
64. Sagar KB, Hastillo A, Wolfgang TC, Lower RR, Hess ML: Left ventricular mass by M-mode echocardiography in cardiac transplant patients with acute rejection. Circulation 1981, 64: II217-220.
65. Yoshida S, Takeuchi K, del Nido PJ, Ho C: Diastolic dysfunction coincides with early mild transplant rejection: in situ measurements in a heterotopic rat heart transplant model. J Heart Lung Transplant 1998, 17: 1049-1056. (Pubitemid 28547272)
66. Nozynski J, Zakliczynski M, Zembala-Nozynska E, Konecka-Mrowka D, Przybylski R, Nikiel B, Lange D, Mrowka A, Przybylski J, Maruszewski M, Zembala M: Remodeling of human transplanted myocardium in ten-year follow-up: a clinical pathology study. Transplant Proc 2007, 39: 2833-2840. (Pubitemid 350088103)
67. Donofrio MT, Clark BJ, Ramaciotti C, Jacobs ML, Fellows KE, Weinberg PM, Fogel MA: Regional wall motion and strain of transplanted hearts in pediatric patients using magnetic resonance tagging. Am J Physiol 1999, 277: R1481-1487.
68. Hansen DE, Daughters GT 2nd, Alderman EL, Stinson EB, Baldwin JC, Miller DC: Effect of acute human cardiac allograft rejection on left ventricular systolic torsion and diastolic recoil measured by intramyocardial markers. Circulation 1987, 76: 998-1008.
69. Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ: Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 2001, 357: 21-28. (Pubitemid 32056497)
70. Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Klocke FJ, Bonow RO, Judd RM: The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 2000, 343: 1445-1453. (Pubitemid 30832880)
71. Moon JC, Reed E, Sheppard MN, Elkington AG, Ho SY, Burke M, Petrou M, Pennell DJ: The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Am Coll Cardiol 2004, 43: 2260-2264. (Pubitemid 38757595)
72. Moon JC, Sheppard M, Reed E, Lee P, Elliott PM, Pennell DJ: The histological basis of late gadolinium enhancement cardiovascular magnetic resonance in a patient with Anderson-Fabry disease. J Cardiovasc Magn Reson 2006, 8: 479-482.
73. Steen H, Merten C, Refle S, Klingenberg R, Dengler T, Giannitsis E, Katus HA: Prevalence of different gadolinium enhancement patterns in patients after heart transplantation. J Am Coll Cardiol 2008, 52: 1160-1167.
74. Marchal G, Van Hecke P, Demaerel P, Decrop E, Kennis C, Baert AL, Schueren E van der: Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T. AJR Am J Roentgenol 1989, 152: 771-775. (Pubitemid 19091936)
75. Deserno WM, Harisinghani MG, Taupitz M, Jager GJ, Witjes JA, Mulders PF, Hulsbergen van de Kaa CA, Kaufmann D, Barentsz JO: Urinary bladder cancer: preoperative nodal staging with ferumoxtran- 10-enhanced MR imaging. Radiology 2004, 233: 449-456. (Pubitemid 39423804)
76. Memarsadeghi M, Riedl CC, Kaneider A, Galid A, Rudas M, Matzek W, Helbich TH: Axillary lymph node metastases in patients with breast carcinomas: assessment with nonenhanced versus uspio-enhanced MR imaging. Radiology 2006, 241: 367-377. (Pubitemid 44632881)
77. Taylor AM, Panting JR, Keegan J, Gatehouse PD, Amin D, Jhooti P, Yang GZ, McGill S, Burman ED, Francis JM, et al.: Safety and preliminary findings with the intravascular contrast agent NC100150 injection for MR coronary angiography. J Magn Reson Imaging 1999, 9: 220-227. (Pubitemid 29115345)
78. Wikstrom LJ, Johansson LO, Ericsson BA, Borseth A, Akeson PA, Ahlstrom KH: Abdominal vessel enhancement with an ultrasmall, superparamagnetic iron oxide blood pool agent: evaluation of dose and echo time dependence at different field strengths. Acad Radiol 1999, 6: 292-298. (Pubitemid 32673374)
79. Kellar KE, Fujii DK, Gunther WH, Briley-Saebo K, Bjornerud A, Spiller M, Koenig SH: NC100150 Injection, a preparation of optimized iron oxide nanoparticles for positive-contrast MR angiography. J Magn Reson Imaging 2000, 11: 488-494. (Pubitemid 30252835)
80. Bjornerud A, Johansson L: The utility of superparamagnetic contrast agents in MRI: theoretical consideration and applications in the cardiovascular system. NMR Biomed 2004, 17: 465-477. (Pubitemid 39549424)
81. Kanno S, Wu YJ, Lee PC, Dodd SJ, Williams M, Griffith BP, Ho C: Macrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles. Circulation 2001, 104: 934-938. (Pubitemid 32778046)
82. Johansson L, Johnsson C, Penno E, Bjornerud A, Ahlstrom H: Acute cardiac transplant rejection: detection and grading with MR imaging with a blood pool contrast agent - experimental study in the rat. Radiology 2002, 225: 97-103.
83. Penno E, Johansson L, Ahlstrom H, Johnsson C: Ultrasmall iron oxide particle contrast agent and MRI can be used to monitor the effect of anti-rejection treatment. Transplantation 2007, 84: 374-379. (Pubitemid 47258326)
84. Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R: Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 2005, 112: 535-543. (Pubitemid 41060794)