Performance of a third-generation TSH-receptor antibody in a UK clinic

Clinical Endocrinology

Volumn 75, Issue 1, 2011, Pages 127-133

  Theodoraki, A ^a   Jones, G ^b   Parker, J ^a   Woolman, E ^b   Martin, N ^b   Perera, S ^a   Thomas, M ^b   Bunn, C ^a   Khoo, B ^a   Bouloux, P M ^a   Vanderpump, M P J ^a  

^a ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^b Clinical Immunology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR ANTIBODY; THYROTROPIN RECEPTOR; MONOCLONAL ANTIBODY; THYROID STIMULATING IMMUNOGLOBULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COST CONTROL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAVES DISEASE; HOSPITAL; HUMAN; HYPERTHYROIDISM; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OBSERVATIONAL STUDY; OUTPATIENT DEPARTMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THYROID DISEASE; THYROID GLAND; UNITED KINGDOM; ADOLESCENT; AGED; CHILD; DIAGNOSTIC USE; EVALUATION STUDY; IMMUNOLOGY; MIDDLE AGED; STANDARDS; THYROID DISEASES; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAVES DISEASE; GREAT BRITAIN; HUMANS; IMMUNOGLOBULINS, THYROID-STIMULATING; MALE; MIDDLE AGED; RECEPTORS, THYROTROPIN; SENSITIVITY AND SPECIFICITY; THYROID DISEASES; YOUNG ADULT;

EID: 79958852568     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04022.x     Document Type: Article

References (30)

1. Okosieme, O.E., Chan, D., Price, S.A., et al. (2010) The utility of radioiodine uptake and thyroid scintigraphy in the diagnosis and management of hyperthyroidism. Clinical Endocrinology, 72, 122-127.
2. Franklyn, J.A., (2010) What is the role of radioiodine uptake measurement and thyroid scintigraphy in the diagnosis and management of hyperthyroidism? Clinical Endocrinology, 72, 11-12.
3. UK guidelines for the Use of Thyroid Function Tests (2006) Association for Clinical Biochemistry, British Thyroid Association, British Thyroid Foundation; patients/Docs/TFT-guideline-final-version-July-2006.pdf
4. Izumi, Y., Takeoka, K., &, Amino, N., (2005) Usefulness of the 2nd generation assay for anti-TSH receptor antibodies to differentiate relapse of Graves' thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for Graves' disease. Endocrine Journal, 52, 493-497. (Pubitemid 41380560)
5. Kamijo, K., Nagata, A., &, Sato, Y., (1999) Clinical significance of a sensitive assay for thyroid-stimulating antibodies in Graves' disease using polyethylene glycol at high concentrations and porcine thyroid cells. Endocrine Journal, 46, 397-403. (Pubitemid 29333947)
6. Cappelli, C., Gandossi, E., Castellano, M., et al. (2007) Prognostic value of thyrotropin receptor antibodies in Graves' disease: a 120 months prospective study. Endocrine Journal, 54, 713-720. (Pubitemid 351377748)
7. Feldt-Rasmussen, U., Schleusener, H., &, Carayon, P., (1994) Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease. Journal of Clinical Endocrinology and Metabolism, 78, 98-102. (Pubitemid 24026755)
8. Carella, C., Mazziotti, G., Sorvillo, F., et al. (2006) Serum thyrotropin receptor antibodies concentrations in patients with Graves' disease before, at the end of methimazole treatment, and after drug withdrawal: evidence that the activity of thyrotropin receptor antibody and/or thyroid response modify during the observation period. Thyroid, 16, 295-302.
9. Schott, M., Morgenthaler, N.G., Fritzen, R., et al. (2004) Levels of autoantibodies against human TSH receptor predict relapse of hyperthyroidism in Graves' disease. Hormones Metabolic Research, 36, 92-96. (Pubitemid 38392248)
10. Takasu, N., Yamashiro, K., Komiya, I., et al. (2000) Remission of Graves' hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody and thyrotropin-binding inhibitor immunoglobulin during antithyroid drug treatment. Thyroid, 10, 891-896.
11. Quadbeck, B., Hoermann, R., Roggenbuck, U., et al. (2005) Basedow Study Group. Sensitive thyrotropin and thyrotropin-receptor antibody determinations one month after discontinuation of antithyroid drug treatment as predictors of relapse in Graves' disease. Thyroid, 15, 1047-1054. (Pubitemid 41475715)
12. Zimmermann-Belsing, T., Nygaard, B., Rasmussen, A.K., et al. (2002) Use of the 2nd generation TRAK human assay did not improve prediction of relapse after antithyroid medical therapy of Graves' disease. European Journal of Endocrinology, 146, 173-177. (Pubitemid 34162908)
13. Ajjan, R.A., &, Weetman, A.P., (2008) Techniques to quantify TSH receptor antibodies. Nature Clinical Practice. Endocrinology & Metabolism, 4, 461-468.
14. Schott, M., Scherbaum, W.A., &, Morgenthaler, N.G., (2005) Thyrotropin receptor autoantibodies in Graves' disease. Trends in Endocrinology and Metabolism, 16, 243-248. (Pubitemid 40853888)
15. Bülow Pedersen, I., Handberg, A., Knusden, N., et al. (2010) Assays for thyroid-stimulating hormone receptor antibodies employing different ligands and ligand partners may have similar sensitivity and specificity but are not interchangeable. Thyroid, 20, 127-133.
16. Smith, B.R., Sanders, J., &, Furmaniak, J., (2007) TSH receptor antibodies. Thyroid, 17, 923-938. (Pubitemid 350071602)
17. Smith, B.R., Bolton, J., Young, S., et al. (2004) A new assay for thyrotropin receptor autoantibodies. Thyroid, 14, 830-835. (Pubitemid 39489008)
18. Eng, J., (2006) ROC Analysis: Web-based Calculator for ROC Curves. Johns Hopkins University, Baltimore. Available from:.
19. Free Software, Diagnostic Test Calculator by Alan Schwartz (version 2010042101). Available from:.
20. Kamijo, K., Ishikawa, K., &, Tanaka, M., (2005) Clinical evaluation of 3rd generation assay for thyrotropin receptor antibodies: the M22-biotin-based ELISA initiated by Smith. Endocrine Journal, 52, 525-529. (Pubitemid 41609039)
21. Zöphel, K., Roggenbuck, D., von Landenberg, P., et al. (2010) TSH receptor antibody (TRAb) assays based on the human monoclonal autoantibody M22 are more sensitive than bovine TSH based assays. Hormones and Metabolic Research, 42, 65-69.
22. Liu, C., Hermsen, D., Domberg, J., et al. (2008) Comparison of M22-based ELISA and human-TSH-receptor-based luminescence assay for the measurement of thyrotropin receptor antibodies in patients with thyroid diseases. Hormones and Metabolic Research, 40, 479-483.
23. Laurberg, P., Wallin, G., Tallstedt, L., et al. (2008) TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. European Journal of Endocrinology, 158, 69-75. (Pubitemid 351211042)
24. Vos, X.G., Smit, N., Endert, E., et al. (2008) Frequency and characteristics of TBII-seronegative patients in a population with untreated Graves' hyperthyroidism: a prospective study. Clinical Endocrinology, 69, 311-317. (Pubitemid 352009024)
25. Mukuta, T., Tamai, H., Oshima, A., et al. (1994) Immunological findings and thyroid function of untreated Graves' disease patients with undetectable TSH-binding inhibitor immunoglobulin. Clinical Endocrinology, 40, 215-219. (Pubitemid 24193151)
26. Paunkovic, J., &, Paunkovic, N., (2006) Does autoantibody-negative Graves' disease exist? A second evaluation of the clinical diagnosis. Hormones and Metabolic Research, 38, 53-56.
27. Kamijo, K., (2010) Study on cutoff value setting for differential diagnosis between Graves' disease and painless thyroiditis using the TRAb (Elecsys TRAb) measurement via the fully automated electrochemiluminescence immunoassay system. Endocrine Journal, 57, 895-902.
28. Bülow Pedersen, B., Knudsen, N., Perrild, H., et al. (2001) TSH-receptor antibody measurement for differentiation of hyperthyroidism into Graves' disease and multinodular toxic goitre: a comparison of two competitive binding assays. Clinical Endocrinology, 55, 381-390. (Pubitemid 32823048)
29. Wallaschofski, H., Orda, C., Georgi, P., et al. (2001) Distinction between autoimmune and non-autoimmune hyperthyroidism by determination of TSH-receptor antibodies in patients with the initial diagnosis of toxic multinodular goiter. Hormones and Metabolic Research, 33, 504-507. (Pubitemid 32881899)
30. Charkes, N.D., (1972) Graves' disease with functioning nodules (Marine-Lenhart syndrome). Journal of Nuclear Medicine, 13, 885-892.