Impedance sensor technology for cell-based assays in the framework of a high-content screening system

Physiological Measurement

Volumn 32, Issue 7, 2011, Pages 977-993

  Schwarzenberger, T ^a   Wolf, P ^a,b   Brischwein, M ^a   Kleinhans, R ^a   Demmel, F ^a,b   Lechner, A ^b   Becker, B ^a,b   Wolf, B ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b HP Medizintechnik GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTONOMOUS AGENTS; CELL CULTURE; DIAGNOSIS; MICROELECTRODES; SIGNAL PROCESSING;

CELL-BASED ASSAYS; CULTURED CELL; EXTERNAL INFLUENCES; HIGH-CONTENT SCREENING; IMPEDANCE MEASUREMENT; IMPEDANCE SENSORS; INTERNAL SIGNALS; PHARMACEUTICAL AGENTS; SCREENING SYSTEM; SENSOR TECHNOLOGIES;

ELECTRIC IMPEDANCE MEASUREMENT;

EID: 79958846203     PISSN: 09673334     EISSN: 13616579     Source Type: Journal    
DOI: 10.1088/0967-3334/32/7/S18     Document Type: Conference Paper

References (23)

1. Atienza J M, Zhu J, Wang X, Xu X and Abassi Y 2005 Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays J. Biomol. Screen. 10 795
2. Berney H and O'Riordan J J 2008 Impedance measurement monitors blood coagulation Technical Report, Analog Dialogue 42-08
3. Bogónez P and Riu P J 2007 Implantable bioimpedance system for measuring the impedance of kidney IFMBE Proc. 17 256
4. Ceriotti L, Ponti J, Broggi F, Kob A, Drechsler S, Thedinga E, Colpo P, Sabbioni E, Ehret R and Rossi F 2007 Real-time assessment of cytotoxicity by impedance measurement on a 96-well plate Sensors Actuators B 123 769
5. Curtis T M, Widder M W, Brennan L M, Schwager S J, Van Der Schalie W H, Fey J and Salazar N 2009 A portable cell-based impedance sensor for toxicity testing of drinking water Lab Chip 9 2176
6. DePaola N, Phelps J E, Florez L, Keese C R, Minnear F L, Giaever I and Vincent P 2001 Electrical impedance of cultured endothelium under fluid flow Ann. Biomed. Eng. 29 648
7. Ehret R, Baumann W, Brischwein M, Schwinde A, Stegbauer K and Wolf B 1997 Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures Biosens. Bioelectron. 12 29
8. Fornari F A, Jarvis W D, Grant S, Orr M S, Randolph J K, White F K H, Mumaw V R, Lovings E T, Freeman R H and Gewirtz D A 1994 Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin Cell Growth Differ. 5 723
9. Giaever I and Keese C R 1993 A morphological biosensor for mammalian cells Nature 366 591
10. Hoja J and Lentka G 2010 Interface circuit for impedance sensors using two specialized single-chip microsystems Sensors Actuators A 163 191
11. Keese C R, Karra N, Dillon B, Goldberg A and Giaever I 1998 Cell-substratum interactions as a predictor of cytotoxicity In Vitr. Mol. Toxicol. 11 183
12. Ko K, Lo C M, Ferrier J, Hannam P, Tamura M, McBride B C and Ellen R P 1998 Cell-substrate impedance analysis of epithelial cell shape and micromotion upon challenge with bacterial proteins that perturb extracellular matrix and cytoskeleton J Microbiol. Methods 34 125
13. Lob V, Geisler T, Brischwein M, Uhl R and Wolf B 2007 Automated live cell screening system based on a 24-well-microplate with integrated micro fluidics Med. Biol. Eng. Comput. 45 1023
14. Mũoz-Berbel X, Vigués N, Cortina-Puig M, Escudé R, García-Aljaro C, Mas J and Mũoz FX 2010 Impedimetric approach for monitoring bacterial cultures based on the changes in the magnitude of the interface capacitance Anal. Methods 2 1036
15. Pliquett U, Frense D, Schönfeld M, Frätzer C, Zhang Y, Cahill B, Metzen M, Barthel A, Nacke T and Beckmann D 2010 Testing miniaturized electrodes for impedance measurements within the beta-dispersion-a practical approach J. Electr. Bioimp. 1 41
16. Schwan H P 1994 Electrical properties of tissues and cell suspensions: mechanisms and models Eng. Med. Biol. Soc. 16th Ann. Int. Conf. IEEE vol 1 p 70
17. Schwarzenberger T, Demmel F, Becker B, Zottmann M, Wolf P, Kleinhans R, Brischwein M, Otto A and Wolf B 2010 Bioimpedance microelectronics in a 24-microwell plate with metabolic-sensors for testing chemosensitivity of tumor cells and tissues J. Phys. Conf. Ser. 224 012141
18. Seoane F, Ferreira J, Sanchéz J J and Bragós R 2008 An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications Physiol. Meas. 29 267
19. Wegener J, Keese C R and Giaever I 2000 Electric cell-substrate impedance sensing as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces Exp. Cell Res. 259 158
20. Wiest J, Schmidhuber M, Grundl D, Brischwein M, Grothe H and Wolf B 2007 Environmental engineering using living cells as signal transducers IEEE AFRICON 2007 accession number 9857302
21. Wiest J, Stadthagen T, Schmidhuber M, Brischwein M, Ressler J, Raeder U, Grothe H, Melzer A and Wolf B 2006 Intelligent mobile lab for metabolics in environmental monitoring Anal. Lett. 39 1759
22. Wolf P, Rothermel A, Beck-Sickinger A and Robitzki A 2008 Microelectrode chip based real time monitoring of vital MCF-7 mamma carcinoma cells by impedance spectroscopy Biosens. Bioelectron. 24 253
23. Yu N, Atienza J M, Bernard J, Blanc S, Zhu J, Wang X, Xu X and Abassi Y 2006 Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to study G protein-coupled receptors Anal. Chem. 78 35