Association of tumor necrosis factor-α and matrix metalloproteinase-3 gene variants with stroke

European Journal of Neurology

Volumn 18, Issue 8, 2011, Pages 1053-1059

  Munshi, A ^a,b   Rajeshwar, K ^a,c   Kaul, S ^d   Al Hazzani, A ^b   Alshatwi, A A ^b   Shafi, G ^b   Balakrishna, N ^e   Jyothy, A ^a  

^a OSMANIA UNIVERSITY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c Dr NTR University of Health Sciences   (India)

^d NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

^e NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

Genetic variants; Ischemic stroke; Matrix metalloproteinase 3; Tumor necrosis factor

Indexed keywords

STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; BRAIN ATHEROSCLEROSIS; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INDIA; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL ANALYSIS; STROKE;

COMORBIDITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; INDIA; MALE; MATRIX METALLOPROTEINASE 3; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STROKE; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS, CENTRAL NERVOUS SYSTEM;

EID: 79958814599     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2010.03334.x     Document Type: Article

References (46)

1. Dichgans M. Genetics of ischemic stroke. Lancet Neurol 2007; 6: 149-161.
2. Munshi A, Kaul S. Stroke genetics - Focus on PDE4D gene. Int J Stroke 2008; 3: 188-192.
3. Munshi A, Kaul S, Aliya L, et al. Prothrombin gene G20210A mutation is not a risk factor for ischemic stroke in a South Indian Hyderabadi population. Thromb Res 2008; 124: 245-247.
4. Munshi A, Shehnaz S, Kaul S, et al. Angiotensin converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population. J Neurol Sci 2008; 272: 132-135.
5. Munshi A, Sai babu M, Kaul S, et al. Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population. J Neurol Sci 2009; 285: 142-145.
6. Munshi A, Rajeshwar K, Kaul S, et al. VNTR polymorphism in intron 4 of the eNOS gene and the risk of ischemic stroke in a South Indian population. Brain Res Bull 2010; 82: 247-250.
7. Munshi A, Sharma V, Kaul S, et al. Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke. J Neurol Sci 2010; 296: 34-38.
8. Flex A, Gaetani E, Papaleo P, et al. Pro-inflammatory genetic profiles in subjects with history of ischemic stroke. Stroke 2004; 35: 2270-2275.
9. Hollegaard MV, Bidwell JL. Cytokine gene polymorphism in human diseases, Supplement 3. Genes Immun 2006; 7: 269-276.
10. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-126.
11. Liu KJ, Rosenberg GA. Matrix metalloproteinases and free radicals in cerebral ischemia. Free Rodic Biol Med 2005; 39: 71-80.
12. Zaremba J. Contribution of tumor necrosis factor alpha to the pathogenesis of stroke. Folia Morphol (Warsz) 2000; 59: 137-143.
13. Feuerstein GZ, Liu T, Barone FC. Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha. Cerebrovasc Brain Metab Rev 1994; 6: 341-360.
14. Hallenbeck JM, Frerichs KU. Stroke therapy. It may be time for an integrated approach. Arch Neurol 1993; 50: 768-770.
15. Kim JS. Cytokines and adhesion molecules in stroke and related diseases. J Neurol Sci 1996; 137: 69-78.
16. Bazzoni F, Beutler B. The tumor necrosis factor ligand and receptor families. N Engl J Med 1996; 334: 1717-1725.
17. DeGraba TJ. Expression of inflammatory mediators and adhesion molecules in human atherosclerotic plaque. Neurology 1997; 49: S15-S19.
18. Barath P, Fishbein MC, Cao J, et al. Detection and localization of tumor necrosis factor in human atheroma. Am J Cardiol 1990; 65: 297-302.
19. Wilson AG, di Giovine FS, Blakemore AI, Duff GW. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1992; 1: 353.
20. Jongeneel CV, Beutler B. Genetic polymorphism in the human TNF region: correlation or causation? J Inflamm 19951996; 46: iii-vi.
21. Sobel RA. Matrix metalloproteinases and diffuse white matter injury. Stroke 2001; 32: 1167-1168.
22. Fornage M, Mosley TH, Jack CR, et al. Family based association study of matrix metalloproteinase-3 and matrix metalloproteinase-9 haplotypes with susceptibility to ischemic white matter injury. Hum Genet 2007; 120: 671-680.
23. Cunnigham LA, Wetzel M, Rosenberg GA. Multiple roles for MMP and TIMPs in cerebral ischemia. Glia 2005; 50: 329-339.
24. Henney AM, Wakeley PR, Davies MJ. Localization of Stromelysin gene expression in atherosclerotic plaques by in situ hybridization. Proc Natl Acad Sci U S A 1991; 88: 8154-8158.
25. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of Matrix metallo proteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 9: 2493-2503.
26. Ye S, Eriksson P, Humsten A, Kurkirnem M, Humphries SE, Henney AM. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which result in reduced gene expression. J Biol Chem 1996; 271: 13055-13060.
27. Meschia JF. Sub typing in ischemic stroke genetic research. J Stroke Cerebravasc Dis 2002; 11: 208-219.
28. Oh BR, Sasaki M, Perinchery G, et al. Frequent genotype changes at -308, and 488 region of the TNF-alpha gene in patients with prostate cancer. J Urol 2000; 163: 1584-1587.
29. Takahashi M, Haro H, Wakabayashi Y, Kawa-uchi T, Komori H, Shinomiya K. The association of degeneration of intervertebral disc with 5A/6A polymorphism in the promoter of the human matrix metalloproteinase-3 gene. J Bone Joint Surg 2001; 83: 491-495.
30. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997; 94: 3195-3199.
31. Um JY, Kim HM. Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction. Brain Res Mol Brain Res 2004; 122: 99-102.
32. Rubattu S, Speranza R, Ferrari M, et al. A role of TNF-alpha gene variant on juvenile ischemic stroke: a case-control study. Eur J Neurol 2005; 12: 989-993.
33. Hoppe C, Klitz C, D'Harlingue K, et al. Confirmation of an association between the TNF(-308) promoter polymorphism and stroke risk in children with sickle cell anemia. Stroke 2007; 38: 2241-2246.
34. Karahan ZC, Deda G, Sipathi T, Elhan AH, Akar N. TNF-alpha -308G/A and IL-6 -174G/C polymorphism in the Turkish pediatric stroke patients. Thromb Res 2005; 115: 393-398.
35. Barone FC, Arvin B, White RF, et al. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 1997; 28: 1233-1244.
36. Feuerstein G, Wang X, Barone FC. Cytokines in brain ischemia-the role of TNF alpha. Cell Mol Neurobiol 1998; 18: 695-701.
37. Liu T, Clark RK, McDonnell PC, et al. Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 1994; 25: 1481-1488.
38. Maemura K, Kurihara H, Morita T, Oh-hashi Y, Yazaki Y. Production of endothelin-1 in vascular endothelial cells is regulated by factors associated with vascular injury. Gerontology 1992; 38: 29-35.
39. Nagase H, Wosssner JF. Matrix metalloproteinases. J Biol Chem 1999; 274: 21491-21494.
40. Gomis-Ruth FX, Maskos K, Betz M, et al. Mechanism of inhibition of the human matrix metalloproteinase stromeolysin-1 by TIMP-1. Nature 1997; 389: 77-81.
41. Rauramaa R, Vaisanen SB, Luong LA, et al. Stromeolysin-1 and interleukin-6 gene polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol 2000; 20: 2657-2662.
42. Ye S, Watts GF, Andalia S, Humpries SC, Henney AM. Preliminary report; genetic variation of the human stromeolysin promoter is associated with progression of coronary atherosclerosis. Br Heart J 1995; 73: 209-215.
43. Kaplan RC, Smith NL, Zucker S, Heckbert SR, Rice K, Psaty BM. Matrix metalloproteinase-3 (MMP-3) and MMP-9 genes and risk of myocardial infarction, ischemic stroke and hemorrhagic stroke. Atherosclerosis 2008; 201: 130-137.
44. Huang X, Zhu M, Jin X, Zhang D, Wang L, Ye Z. Association of Matrix metalloproteinase-3 serum level and the promoter 5A/ 6A polymorphism of the MMP3 gene with atherosclerotic cerebral infarction. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008; 25: 653-656.
45. Ye S, Humphries S, Henney A. Matrix metalloproteinases: implication in vascular matrix remodelling during atherogenesis. Clin Sci 1998; 94: 103-110.
46. Koch W, de Waha A, Hopmann P, Schomig A, Kastrati A. Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase - 3 gene in coronary disease: case-control study and a meta-analysis. Atherosclerosis 2010; 208: 171-176.