Food effect and biocomparison of two formulations of the dual orexin receptor antagonist almorexant in healthy male subjects

Journal of Clinical Pharmacology

Volumn 51, Issue 7, 2011, Pages 1116-1121

  Hoch, Matthias ^a,c   Hoever, Petra ^a   Haschke, Manuel ^b   Krähenbühl, Stephan ^b   Dingemanse, Jasper ^a  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c NONE   (Switzerland)

Author keywords

Biocomparison; food effect; orexin; pharmacodynamics; pharmacokinetics

Indexed keywords

ALMOREXANT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DISPOSITION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FOOD; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; RANDOMIZED CONTROLLED TRIAL; RESPONSE TIME; SINGLE DRUG DOSE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION; VISUAL ANALOG SCALE; VISUAL STIMULATION;

ACETAMIDES; ADULT; BIOLOGICAL AVAILABILITY; CAPSULES; CROSS-OVER STUDIES; FOOD-DRUG INTERACTIONS; HALF-LIFE; HUMANS; HYPNOTICS AND SEDATIVES; ISOQUINOLINES; MALE; REACTION TIME; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; TABLETS; TASK PERFORMANCE AND ANALYSIS; THERAPEUTIC EQUIVALENCY; WAKEFULNESS; YOUNG ADULT;

EID: 79958806531     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270010377634     Document Type: Article

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