Reduction in antibiotic use following a cluster randomized controlled multifaceted intervention: The Israeli judicious antibiotic prescription study

Clinical Infectious Diseases

Volumn 53, Issue 1, 2011, Pages 33-41

  Regev Yochay, Gili ^a,b,c   Raz, Meir ^d   Dagan, Ron ^e   Roizin, Hector ^d   Morag, Benjamin ^d   Hetman, Shmuel ^d   Ringel, Sigal ^d   Ben Israel, Neta ^d   Varon, Miriam ^d   Somekh, Eli ^b,d,f   Rubinstein, Ethan ^a,b,g  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d MACCABI HEALTHCARE SERVICES   (Israel)

^e BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^f WOLFSON MEDICAL CENTER   (Israel)

^g UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; LONG ACTING DRUG; MACROLIDE; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; CHILD; COMMUNICATION SKILL; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENERAL PRACTITIONER; HEALTH EDUCATION; HEALTH PROMOTION; HUMAN; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MEDICAL PRACTICE; PHYSICIAN ATTITUDE; PRACTICE GUIDELINE; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PROFESSIONAL KNOWLEDGE; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DRUG PRESCRIPTIONS; DRUG UTILIZATION; HUMANS; INFANT; ISRAEL; PEDIATRICS; PHYSICIAN'S PRACTICE PATTERNS; POISSON DISTRIBUTION;

EID: 79958803745     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cir272     Document Type: Article

References (45)

1. Livermore DM. Has the era of untreatable infections arrived? J Antimicrob Chemother 2009; 64(suppl 1):i29-36.
2. Albrich WC, Monnet DL, Harbarth S. Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes. Emerg Infect Dis 2004; 10:514-7. (Pubitemid 38314485)
3. Lipsitch M, Samore MH. Antimicrobial use and antimicrobial resistance: a population perspective. Emerg Infect Dis 2002; 8:347-54. (Pubitemid 34415194)
4. Goossens H, Ferech M, Vander Stichele R, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: a crossnational database study. Lancet 2005; 365:579-87. (Pubitemid 40247914)
5. Nyquist AC, Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA 1998; 279:875-7. (Pubitemid 28185554)
6. Guillemot D, Varon E, Bernede C, et al. Reduction of antibiotic use in the community reduces the rate of colonization with penicillin Gnonsusceptible Streptococcus pneumoniae. Clin Infect Dis 2005; 41:930-8. (Pubitemid 41368213)
7. Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D. Why do paediatricians prescribe antibiotics? results of an Italian regional project. BMC Pediatr 2009; 9:69.
8. Butler CC, Hood K, Verheij T, et al. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 2009; 338:b2242.
9. Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009; 302:758-66.
10. Gjelstad S, Dalen I, Lindbaek M. GPs' antibiotic prescription patterns for respiratory tract infections-still room for improvement. Scand J Prim Health Care 2009; 27:208-15.
11. Owens RC Jr, Shorr AF, Deschambeault AL. Antimicrobial stewardship: shepherding precious resources. Am J Health Syst Pharm 2009; 66(12 suppl 4):S15-22.
12. El Sayed MF, Tamim H, Jamal D, Mumtaz G, Melki I, Yunis K. Prospective study on antibiotics misuse among infants with upper respiratory infections. Eur J Pediatr 2009; 168:667-72.
13. Huang SS, Rifas-Shiman SL, Kleinman K, et al. Parental knowledge about antibiotic use: results of a cluster-randomized, multicommunity intervention. Pediatrics 2007; 119:698-706. (Pubitemid 46556668)
14. Bekkers MJ, Simpson SA, Dunstan F, et al. Enhancing the quality of antibiotic prescribing in primary care: qualitative evaluation of a blended learning intervention. BMC Fam Pract 2010; 11:34.
15. Sabuncu E, David J, Bernede-Bauduin C, et al. Significant reduction antibiotic use community after a nationwide campaign in France, 2002-2007. PLoS Med 2009; 6:e1000084.
16. Bauchner H, Osganian S, Smith K, Triant R. Improving parent knowledge about antibiotics: a video intervention. Pediatrics 2001; 108:845-50. (Pubitemid 32947651)
17. Finch RG, Metlay JP, Davey PG, Baker LJ. Educational interventions to improve antibiotic use in the community: report from the International Forum on Antibiotic Resistance (IFAR) colloquium, 2002. Lancet Infect Dis 2004; 4:44-53. (Pubitemid 38057058)
18. Rautakorpi UM, Huikko S, Honkanen P, et al. The Antimicrobial Treatment Strategies (MIKSTRA) program: a 5-year follow-up of infection- specific antibiotic use in primary health care and the effect of implementation of treatment guidelines. Clin Infect Dis 2006; 42:1221-30.
19. Buising KL, Thursky KA, Black JF, et al. Improving antibiotic prescribing for adults with community acquired pneumonia: does a computerised decision support system achieve more than academic detailing alone? a time series analysis. BMC Med Inform Decis Mak 2008; 8:35.
20. Samore MH, Bateman K, Alder SC, et al. Clinical decision support and appropriateness of antimicrobial prescribing: a randomized trial. JAMA 2005; 294:2305-14. (Pubitemid 41607406)
21. Ranji SR, Steinman MA, Shojania KG, Gonzales R. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care 2008; 46:847-62.
22. Masia M, Matoses C, Padilla S, et al. Limited efficacy of a nonrestricted intervention on antimicrobial prescription of commonly used antibiotics in the hospital setting: results of a randomized controlled trial. Eur J Clin Microbiol Infect Dis 2008; 27:597-605.
23. Gonzales R, Corbett KK, Wong S, et al. "Get smart Colorado": impact of a mass media campaign to improve community antibiotic use. Med Care 2008; 46:597-605.
24. Taylor JA, Kwan-Gett TS, McMahon EM Jr. Effectiveness of a parental educational intervention in reducing antibiotic use in children: a randomized controlled trial. Pediatr Infect Dis J 2005; 24:489-93. (Pubitemid 40847520)
25. Thompson PL, Spyridis N, Sharland M, et al. Changes in clinical indications for community antibiotic prescribing for children in the UK from 1996 to 2006: will the new NICE prescribing guidance on upper respiratory tract infections just be ignored? Arch Dis Child 2009; 94:337-40.
26. Rubin MA, Bateman K, Alder S, Donnelly S, Stoddard GJ, Samore MH. A multifaceted intervention to improve antimicrobial prescribing for upper respiratory tract infections in a small rural community. Clin Infect Dis 2005; 40:546-53. (Pubitemid 40270224)
27. Arnold SR, Straus SE. Interventions to improve antibiotic prescribing practices in ambulatory care. Cochrane Database Syst Rev 2005; (4):CD003539.
28. Samore MH, Lipsitch M, Alder SC, et al. Mechanisms by which antibiotics promote dissemination of resistant pneumococci in human populations. Am J Epidemiol 2006; 163:160-70. (Pubitemid 43068985)
29. Dagan R, Barkai G, Leibovitz E, Dreifuss E, Greenberg D. Will reduction of antibiotic use reduce antibiotic resistance? the pneumococcus paradigm. Pediatr Infect Dis J 2006; 25:981-6. (Pubitemid 44510610)
30. Heffelfinger JD, Davis TE, Gebrian B, Bordeau R, Schwartz B, Dowell SF. Evaluation of children with recurrent pneumonia diagnosed by World Health Organization criteria. Pediatr Infect Dis J 2002; 21:108-12. (Pubitemid 34150607)
31. Clinical practice guideline: management of sinusitis. Pediatrics 2001; 108:798-808.
32. Jacobs RF. Judicious use of antibiotics for common pediatric respiratory infections. Pediatr Infect Dis J 2000; 19:938-43.
33. Bisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH. Diagnosis and management of group A streptococcal pharyngitis: a practice guideline. Infectious Diseases Society of America. Clin Infect Dis 1997; 25:574-83. (Pubitemid 127774276)
34. Maor Y, Raz M, Rubinstein E, et al. Changing parents' opinions regarding antibiotic use in primary care. Eur J Pediatr 2011; 170:359-64.
35. Barlow G, Nathwani D, Williams F, et al. Reducing door-to-antibiotic time in community-acquired pneumonia: controlled before-and-after evaluation and cost-effectiveness analysis. Thorax 2007; 62:67-74. (Pubitemid 46110371)
36. Steinman MA, Gonzales R, Linder JA, Landefeld CS. Changing use of antibiotics in community-based outpatient practice, 1991-1999. Ann Intern Med 2003; 138:525-33.
37. Finkelstein JA, Huang SS, Kleinman K, et al. Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts. Pediatrics 2008; 121:e15-23.
38. Belongia EA, Sullivan BJ, Chyou PH, Madagame E, Reed KD, Schwartz B. A community intervention trial to promote judicious antibiotic use and reduce penicillin-resistant Streptococcus pneumoniae carriage in children. Pediatrics 2001; 108:575-83. (Pubitemid 32786583)
39. Perz JF, Craig AS, Coffey CS, et al. Changes in antibiotic prescribing for children after a community-wide campaign. JAMA 2002; 287:3103-9. (Pubitemid 34633985)
40. Francis NA, Butler CC, Hood K, Simpson S, Wood F, Nuttall J. Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial. BMJ 2009; 339:b2885.
41. Butler CC, Hood K, Kelly MJ, et al. Treatment of acute cough/lower respiratory tract infection by antibiotic class and associated outcomes: a 13 European country observational study in primary care. J Antimicrob Chemother 2010; 65:2472-8.
42. Arnold SR, Bush AJ. Decline in inappropriate antibiotic use over a decade by pediatricians in a Tennessee community. Ambul Pediatr 2006; 6:225-9.
43. Hrisos S, Eccles M, Johnston M, et al. Developing the content of two behavioural interventions: using theory-based interventions to promote GP management of upper respiratory tract infection without prescribing antibiotics #1. BMC Health Serv Res 2008; 8:11.
44. Grol R. Personal paper: beliefs and evidence in changing clinical practice. BMJ 1997; 315:418-21. (Pubitemid 27346046)
45. Nitzan O, Low M, Lavi I, Hammerman A, Klang S, Raz R. Variability in outpatient antimicrobial consumption in Israel. Infection 2010; 38:12-18.