Study on hepatotoxicity of cytisine (Tabex®) compared with nicotine in freshly isolated rat hepatocytes

Pharmacia

Volumn 56, Issue 1-4, 2009, Pages 27-32

  Micheva, M ^a   Kondeva Burdina, Magdalena ^a   Vicheva, V ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Cytisine; Hepatotoxicity; Isolated rat hepatocytes; Nicotine

Indexed keywords

CYTISINE; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; NICOTINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DRUG EFFECT; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

EID: 79958778618     PISSN: 04280296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Angelova, O. Studies of the acute toxicity of Tabex. Scientific documentation of the Chemical-Pharmaceutical Institute, Sofia (in Bulgarian). - BPG Ltd information, 1966.
2. Bergmeyer, H. U., K. Gawehn et M. Grassl. - In: Bergmeyer H. U. Methods of Enzymatic Analysis (Vol.1). Weinheim: Verlag Chemie, 1974, 481-482.
3. Bray, T. M. et C. G. Tayler. Tissue glutathione, nutrition and oxidative stress. - Can. J. Physiol. Pharmacol., 71, 1993, 746-751.
4. Cormier, A. et al. In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation. - Brain Res., 900, 2001, No 1, 72-79.
5. Cormier, A. et al. Nicotine protects rat brain mitochondria against experimental injuries. - Neuropharmacology, 44, 2003, No 5, 642-652. (Pubitemid 36369143)
6. Dani, J. A. et R. A. Harris. Nicotine addiction and comorbidity with alcohol abuse and mental illness. - Nat. Neurosci., 8, 2005, 1465-1470.
7. Fau, D. et al. Mechanism for the hepatotoxicity of the antiandrogen, Nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug lead to oxidative stress in isolated hepatocytes. - J. Pharmacol. Exp. Ther., 263, 1992, No 1, 69-77.
8. Free, R. B. et al. Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK293 cells. - Neurosci. Lett., 343, 2003, No 3, 180-184.
9. Glockner, R. et D. Muller. Ethoxycoumarin odeethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro. - Exp. Toxicol. Phatol., 47, 1995, No 4, 319-324.
10. Guilluozo, A. Utilization des hepatocytes isolès et en culture pour des ètudes de mètabolisme et de cytotoxicitè des sènobiotiques. - In: Guiiluozo, A. et Ch. Guilluozo, Recherches en Hepatocytes Isolès et en Culture, Paris: John Libbey Eurotext Ltd, 1986, 327-346.
11. Kauer, J. A. Neuroscience: on receptors in nicotine addiction. - Nature, 436, 2005, 31.
12. Lim, D. Y., S. J. Jang et K. C. Kim. Influence of cytisine on catecholamine release in isolated perfused rat adrenal glands. - Arch. Pharm. Res., 25, 2002, No 6, 932-939.
13. Mitcheva, M, M. Kondeva, V. Vitcheva, P. Nedialkov et G. Kitanov. Effect of benzophenones from Hypericum annulatum on carbon tetrachloride-induced toxicity in freshly isolated rat hepatocytes. - Redox Rep., 11,, 2006, No 1, 3-8. (Pubitemid 44111117)
14. Peto, R. et al. Mortality from smoking worldwide. - Br. Med. Bull., 52,, 1996, No 1, 12-21.
15. Pianezza, M. L., E. M. Sellers et R. F. Tyndale. Nicotine metabolism defect reduces smoking. - Nature, 393, 1998, No 6687, 750. (Pubitemid 28299478)
16. Prior, C. et S. Singh. Factors influencing the low-frequency associated Ach autoreceptor-mediated depression of Ach release from rat motor nerve terminals. - Br. J. Pharmacol., 129, 2000, No 6, 1067-1074.
17. Si, M. L. et al. Statins prevent beta-amyloid inhibition of sympathetic alpha7-nACh-mediated nitrergic neurogenic dilation inporcine basilar arteries. - J. Cereb. Blood. Flow. Metab, 25, 2005, No 12, 1573-1585.
18. Wei, X. M. et al. Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells. - Respir. Res, 6, 2005, No 108, 1-9.
19. Yildiz, D., N. Ercal et D. W. Armstrong. Nicotine enantiomers and oxidative stress. - Toxicology, 130, 1998, No 2-3, 155-165.