Inhalation of 7.5% carbon dioxide increases threat processing in humans

Neuropsychopharmacology

Volumn 36, Issue 8, 2011, Pages 1557-1562

  Garner, Matthew ^a,b   Attwood, Angela ^c   Baldwin, David S ^a   James, Alexandra ^c   Munafò, Marcus R ^c  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

antisaccade; anxiety; attention; CO 2; cognition; emotion processing

Indexed keywords

CARBON DIOXIDE;

ADULT; AFFECT; ALERTNESS; ANXIETY; AROUSAL; ARTICLE; AUTONOMIC INNERVATION; BLOOD PRESSURE; CARBON DIOXIDE BREATHING; CONTROLLED STUDY; CORRELATION ANALYSIS; ERROR; FEAR; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; LATENT PERIOD; MALE; MOOD CHANGE; NORMAL HUMAN; PRIORITY JOURNAL; RELIABILITY; SACCADIC EYE MOVEMENT; SELECTIVE ATTENTION; TASK PERFORMANCE; THREAT; VISUAL STIMULATION;

ADMINISTRATION, INHALATION; ADOLESCENT; ANXIETY; AROUSAL; CARBON DIOXIDE; FEAR; FEMALE; HUMANS; MALE; PSYCHOMOTOR PERFORMANCE; SACCADES; YOUNG ADULT;

EID: 79958774931     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.15     Document Type: Article

References (34)

1. Ansari TL, Derakshan N, Richards A (2008). Effects of anxiety on task switching: evidence from the mixed antisaccade task. Cogn Affect Behav Neurosci 8: 229-238.
2. 2 in human volunteers. Depress Anxiety 21: 18-25. (Pubitemid 40614545)
3. 2 challenge? J Psychopharmacol 17: 252-259. (Pubitemid 37150829)
4. 2 model of GAD using paroxetine and lorazepam in healthy volunteers. J Psychopharmacol 21: 42-49. (Pubitemid 46012082)
5. 2 inhalationFa translational trans-species model of anxiety? Pharmacol Biochem Be 90: 51-57.
6. Bar-Haim YD, Lamy D, Pergamin L, Bakermans-Kranenburg MJ, vanljendoorn MH (2007). Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study. Psychol Bull 133: 1-24.
7. Bishop SJ (2007). Neurocognitive mechanisms of anxiety: an integrative account. Trends Cogn Sci 11: 307-316. (Pubitemid 46962335)
8. Bishop SJ, Duncan J, Lawrence AD (2004a). State anxiety modulation of the amygdala response to unattended threat-related stimuli. J Neurosci 24: 10364-10368. (Pubitemid 39552620)
9. Bishop S, Duncan J, Lawrence AD (2004b). Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli. Nat Neurosci 7: 184-188. (Pubitemid 38129795)
10. Browning M, Holmes EA, Murphy SE, Goodwin GM (2010). Lateral Prefrontal Cortex Mediates the Cognitive Modification of Attentional Bias. Biological Psychiatry 67: 919-925.
11. Center for the Study of Emotion and Attention (1999). The International Affective Picture System (IAPS). Gainesville, FL: The Center for Research in Psychophysiology, University of Florida.
12. Colasanti A, Salamon E, Schruers K, van Diest R, van Duinen M, Griez EJ (2008). Carbon dioxide-induced emotion and respiratory symptoms in healthy volunteers. Neuropsychopharmacol 33: 3103-3110.
13. Davidson RJ (2002). Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry 51: 68-80. (Pubitemid 34093795)
14. Davis M, Whalen PJ (2001). The amygdala: vigilance and emotion. Mol Psychiatry 6: 13-34. (Pubitemid 32096061)
15. Ettinger U, Ffytche DH, Kumari V, Kathmann N, Reuter B, Zelaya F et al (2008). Decomposing the neural correlates of antisaccade eye movements using event-related fMRI. Cereb Cortex 18: 1148-1159.
16. Eysenck MW, Derakshan N, Santos R, Calvo MG (2007). Anxiety and cognitive performance: attentional control theory. Emotion 7: 336-353. (Pubitemid 46800375)
17. Garner M, Ainsworth B, Gould H, Gardner H, Baldwin DS (2009). Impaired attentional control in high and low anxious healthy volunteers: evidence from the antisaccade task. Eur Neuro-psychopharm 19: S599.
18. Grefkes C, Wang LE, Eickhoff SB, Fink GR (2010). Noradrenergic modulation of cortical networks engaged in visuomotor processing. Cereb Cortex 20: 783-797.
19. Hayes S, Hirsch C, Mathews A (2008). Restriction of working memory capacity during worry. J Abnorm Psychol 117: 712-717.
20. Kim MJ, Whalen PJ (2009). The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety. J Neurosci 29: 11614-11618.
21. Kirschbaum C, Pirke KM, Hellhammer DH (1993). The Trier Social Stress TestFa tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28: 76-81. (Pubitemid 23283755)
22. Mogg K, Millar N, Bradley BP (2000). Biases in eye movements to threatening facial expressions in generalized anxiety disorder and depressive disorder. J Abnorm Psychol 109: 695-704. (Pubitemid 32096229)
23. Monk CS, Telzer EH, Mogg K, Bradley BP, Mai XQ, Louro HMC et al (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiat 65: 568-576. (Pubitemid 351645052)
24. Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ et al (2009). Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 166: 302-310.
25. Paulus MP, Stein MB (2006). An insular view of anxiety. Biol Psychiatry 60: 383-387. (Pubitemid 44215849)
26. Pineda J, Aghajanian GK (1997). Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience 77: 723-743. (Pubitemid 27092133)
27. Poma SZ, Milleri S, Squassante L, Nucci G, Bani M, Perini GI et al (2005). Characterization of a 7% carbon dioxide (CO2) inhalation paradigm to evoke anxiety symptoms in healthy subjects. J Psychopharmacol 19: 494-503. (Pubitemid 41392304)
28. Sheehan DV, Lecrubier Y, Harnett-Sheehan K, Amorim P, Janavs J, Weiller E et al (1998). The Mini International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview. J Clin Psychiatry 59: 22-33. (Pubitemid 29001829)
29. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
30. Stein MB, Simmons AN, Feinstein JS, Paulus MP (2007). Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. Am J Psychiatry 164: 318-327.
31. Taylor S, Cox BJ (1998). An expanded anxiety sensitivity index: evidence for a hierarchic structure in a clinical sample. J Anxiety Disord 12: 463-483. (Pubitemid 28484840)
32. Van Den Hout MA, Griez E (1984). Panic symptoms after inhalation of carbon dioxide. Brit J Psychiat 144: 503-507. (Pubitemid 14140009)
33. Watson D, Clark LA, Tellegen A (1988). Development and validation of brief measures of positive and negative affect: the PANAS scale. J Pers Soc Psychol 54: 1063-1070.
34. Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Coryell MW, Wunsch AM et al (2009). The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 139: 1012-1021.