Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts

Steroids

Volumn 76, Issue 8, 2011, Pages 741-744

  Chand, Ashwini L ^a   Herridge, Kerrie A ^a   Howard, Tamara L ^a   Simpson, Evan R ^a   Clyne, Colin D ^a  

^a MONASH MEDICAL CENTRE   (Australia)

Author keywords

Aromatase; Breast cancer; LRH 1; NR5A2

Indexed keywords

AROMATASE; AROMATASE PROMOTER II; FORSKOLIN; LIVER RECEPTOR HOMOLOG 1; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; REGULATOR PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; BREAST ADIPOSE STROMAL FIBROBLAST; CHROMATIN IMMUNOPRECIPITATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; FIBROBLAST; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PLASMID; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; STROMA CELL;

ADIPOSE TISSUE; AROMATASE; BREAST; BREAST NEOPLASMS; CHROMATIN IMMUNOPRECIPITATION; DINOPROSTONE; FEMALE; FIBROBLASTS; FORSKOLIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKOUT TECHNIQUES; HUMANS; ORGAN SPECIFICITY; POSTMENOPAUSE; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, SMALL INTERFERING; STROMAL CELLS; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 79958772144     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.02.024     Document Type: Conference Paper

References (25)

1. Simpson ER, Davis SR. Minireview: aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 2001;142(11):4589-94. (Pubitemid 33022332)
2. Bulun SE, Simpson ER. Regulation of aromatase expression in human tissues. Breast Cancer Res Treat 1994;30(1):19-29. (Pubitemid 24250756)
3. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Corbin CJ, Mendelson CR. Tissue-specific promoters regulate aromatase cytochrome P450 expression. J Steroid Biochem Mol Biol 1993;44(4-6):321-30. (Pubitemid 23126602)
4. Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. J Biol Chem 2008;283(6):3433-44.
5. Zhao Y, Agarwal VR, Mendelson CR, Simpson ER. Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 1996;137(12):5739-42. (Pubitemid 26423150)
6. Clyne CD, Speed CJ, Zhou J, Simpson ER. Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 2002;277(23):20591-7. (Pubitemid 34967360)
7. Bouchard MF, Taniguchi H, Viger RS. Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells. Endocrinology 2005;146(11):4905-16. (Pubitemid 41446629)
8. Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, et al. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 2010;6(2):167-74.
9. Wagner RT, Xu X, Yi F, Merrill BJ, Cooney AJ. Canonical Wnt/beta-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expression. Stem Cells 2010;28(10):1794-804.
10. Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, et al. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol 2005;25(9):3492-505. (Pubitemid 40575723)
11. Fayard E, Auwerx J, Schoonjans K. LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol 2004;14(5):250-60. (Pubitemid 38591329)
12. Botrugno OA, Fayard E, Annicotte JS, Haby C, Brennan T, Wendling O, et al. Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell 2004;15(4):499-509. (Pubitemid 39141778)
13. Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, et al. Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation. Proc Natl Acad Sci U S A 2005;102(6):2058-62. (Pubitemid 40262011)
14. Miki Y, Clyne CD, Suzuki T, Moriya T, Shibuya R, Nakamura Y, et al. Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: possible regulator of in situ steroidogenesis. Cancer Lett 2006;244(1):24-33. (Pubitemid 44485861)
15. Wang SL, Zheng DZ, Lan FH, Deng XJ, Zeng J, Li CJ, et al. Increased expression of hLRH-1 in human gastric cancer and its implication in tumorigenesis. Mol Cell Biochem 2008;308(1-2):93-100. (Pubitemid 351167849)
16. Annicotte JS, Chavey C, Servant N, Teyssier J, Bardin A, Licznar A, et al. The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Oncogene 2005;24(55):8167-75. (Pubitemid 41759815)
17. Chand A, Herridge KA, Thompson EW, Clyne C. The orphan nuclear receptor LRH-1 promotes breast cancer motility and invasion. Endocr Relat Cancer 2010;17(4):965-75.
18. Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, et al. Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. Cancer Res 2005;65(24):11762-70. (Pubitemid 41821738)
19. Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER. Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab 1981;53(2):412-7. (Pubitemid 13250304)
20. Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR, Simpson ER. Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. Cancer Res 2009;69(13):5392-9.
21. Chand AL, Simpson ER, Clyne CD. Aromatase expression is increased in BRCA1 mutation carriers. BMC Cancer 2009;9:148.
22. Agarwal VR, Bulun SE, Leitch M, Rohrich R, Simpson ER. Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J Clin Endocrinol Metab 1996;81(11):3843-9. (Pubitemid 26380384)
23. Chen D, Reierstad S, Lin Z, Lu M, Brooks C, Li N, et al. Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblasts. Cancer Res 2007;67(18):8914-22.
24. Zhou J, Suzuki T, Kovacic A, Saito R, Miki Y, Ishida T, et al. Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer. Cancer Res 2005;65(2):657-63.
25. Thiruchelvam PT, Lai CF, Hua H, Thomas RS, Hurtado A, Hudson W, et al. The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells. Breast Cancer Res Treat 2010. doi:10.1007/s10549-010-0994-9.